Results 71 to 80 of about 1,098,781 (385)

Killer immunoglobulin-like receptor (KIR) and HLA genotypes affect the outcome of allogeneic kidney transplantation. [PDF]

open access: yesPLoS ONE, 2012
BACKGROUND: Recipient NK cells may detect the lack of recipient's (i.e., self) HLA antigens on donor renal tissue by means of their killer cell immunoglobulin-like receptors (KIRs).
Izabela Nowak   +15 more
doaj   +1 more source

Why do we reject a graft? Role of indirect allorecognition in graft rejection [PDF]

open access: yesKidney International, 1999
renal transplant dysfunction, as manifested by a slow, progressive rise in serum creatinine, developed; the decreasing renal function was associated with proteinuria (1 to 2 g/24 hr). The erratic cyclosporine levels and blood pressure readings led to the suspicion that he remained noncompliant with his medications.
openaire   +3 more sources

Embedded 3D‐Coaxial Bioprinting of Stenotic Brain Vessels with a Mechanically Enhanced Extracellular Matrix Bioink for Investigating Hemodynamic Force‐Induced Endothelial Responses

open access: yesAdvanced Functional Materials, EarlyView.
In this study, a physically enhanced vascular dECM bioink and used 3D‐coaxial bioprinting are developed to fabricate mature brain blood vessels for cerebral atherosclerosis research. This model demonstrates that vascular geometry‐induced hemodynamic changes trigger vascular inflammation, ensuring its potential for cerebrovascular research.
Wonbin Park   +7 more
wiley   +1 more source

Disease recurrence and rejection following liver transplantation for autoimmune chronic active liver disease [PDF]

open access: yes, 1992
Autoimmune chronic active liver disease (ACALD), a major indication for liver transplantation, is associated strongly with antigenic determinants HLA-B8 and DR3.
Block, GD   +6 more
core   +1 more source

Anionic Citrate‐Based 3D‐Printed Scaffolds for Tunable and Sustained Orthobiologic Delivery to Enhance Tissue Regeneration

open access: yesAdvanced Functional Materials, EarlyView.
A potent anionic citric acid‐based 3D‐printed scaffold is developed for the sustained and controlled release of orthobiologics to enhance orthopedic therapeutic efficacy. Comprehensive in vivo studies demonstrated effective bone fusion and high safety at a low dose of BMP‐2 delivered by the system, establishing it as a promising platform for safe ...
Se‐Hwan Lee   +12 more
wiley   +1 more source

Resident memory T cells form during persistent antigen exposure leading to allograft rejection

open access: yesScience immunology, 2021
Recipient effector T cells differentiate into functional tissue-resident memory T cells, causing graft rejection after kidney transplantation. Memories of rejection Long-term graft survival after organ transplantation can be hindered by immune-mediated ...
Khodor I. Abou-Daya   +8 more
semanticscholar   +1 more source

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

open access: yesAdvanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu   +7 more
wiley   +1 more source

Deciphering the impact of senescence in kidney transplant rejection: An integrative machine learning and multi-omics analysis via bulk and single-cell RNA sequencing.

open access: yesPLoS ONE
BackgroundThe demographic shift towards an older population presents significant challenges for kidney transplantation (KTx), particularly due to the vulnerability of aged donor kidneys to ischemic damage, delayed graft function, and reduced graft ...
Xihao Shen   +5 more
doaj   +1 more source

Cytokines and graft function in heart transplant recipients [PDF]

open access: yes, 2002
Allo-antigen dependent and independent factors early after heart transplantation lead to a response-to-injury mechanism that may determine later outcome in terms of acute rejection, chronic rejection, graft dysfunction, and mortality. 13·24'30'53 The aim
Groot-Kruseman, H.A. de
core  

Cadaveric small bowel and small bowel-liver transplantation in humans [PDF]

open access: yes, 1992
Five patients had complete cadaveric small bowel transplants under FK506 immunosuppression, one as an isolated graft and the other 4 in continuity with a liver. Three were children and two were adults.
Abu-Elmagd, K   +13 more
core   +1 more source

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