Results 51 to 60 of about 7,846,955 (114)

A randomized phase II trial of tacrolimus, mycophenolate mofetil and sirolimus after non-myeloablative unrelated donor transplantation

Haematologica, 2014
The study is a randomized phase II trial investigating graft-versus-host disease prophylaxis after non-myeloablative (90 mg/m2 fludarabine and 2 Gy total body irradiation) human leukocyte antigen matched unrelated donor transplantation.
Brian Kornblit, David G. Maloney, Barry E. Storer, Michael B. Maris, Lars Vindeløv, Parameswaran Hari, Amelia A. Langston, Michael A. Pulsipher, Wolfgang A. Bethge, Thomas R. Chauncey, Thoralf Lange, Finn B. Petersen, Kai Hübel, Ann E. Woolfrey, Mary E.D. Flowers, Rainer Storb, Brenda M. Sandmaier   +16 more
doaj   +1 more source

Chronic graft-versus-host disease and its management in children [PDF]

, 2002
Chronic graft-versus-host disease is sometimes a severe, disabling and long-lasting complication of allogeneic hematopoietic stem cell transplantation.
L. Breedeveld, J.D.J. Bakker, M.H. van Weel-Sipman, B. Mertens, J.M. Vossen, Vossen, J.M.; Department of Pediatrics, Leiden University Medical Center, P.O. Box. 9600, 2300 RC Leiden the Netherlands, Breedeveld, L.; Department of Pediatrics, Leiden University Medical Center, P.O. Box. 9600, 2300 RC Leiden the Netherlands, Bakker, J.D.J.; Department of Pediatrics, Leiden University Medical Center, P.O. Box. 9600, 2300 RC Leiden the Netherlands, Mertens, B.; Department of Medical Statistics, Leiden University Medical Center, Leiden, the Netherlands, van Weel-Sipman, M.H.; Department of Pediatrics, Leiden University Medical Center, P.O. Box. 9600, 2300 RC Leiden the Netherlands   +9 more
core   +2 more sources

Using Gene Editing Approaches to Fine-Tune the Immune System

Frontiers in Immunology, 2020
Genome editing technologies not only provide unprecedented opportunities to study basic cellular system functionality but also improve the outcomes of several clinical applications.
Kristina Pavlovic, Kristina Pavlovic, María Tristán-Manzano, Noelia Maldonado-Pérez, Marina Cortijo-Gutierrez, Sabina Sánchez-Hernández, Pedro Justicia-Lirio, Pedro Justicia-Lirio, M. Dolores Carmona, Concha Herrera, Concha Herrera, Francisco Martin, Karim Benabdellah   +12 more
doaj   +1 more source

Graft versus host disease in oncology nursing practice

, 2014
INTRODUCTION: \ud \ud Gastrointestinal graft-versus-host disease (GI-GvHD) is extremely debilitating and is multifactorial in its causative factors, management and treatment.
Christensen, Martin, Lieow, Yuuki, Christensen, Martin (R19257)   +2 more
core   +1 more source

Body Composition Assessment Provides Prognostic Information in Patients With Cancer Affected by Chronic Graft vs. Host Disease

Journal of Cachexia, Sarcopenia and Muscle
Background Additional tools are needed to assess mortality risk among patients with cancer. Patients with chronic graft vs. host disease (cGVHD) after allogeneic haematopoietic cell transplantation (HCT) represent a high‐risk cancer population with ...
Asmita Mishra, Ram Thapa, Kevin Bigam, Martine Extermann, Rawan Faramand, Farhad Khimani, Xuefeng Wang, Vickie Baracos, Joseph A. Pidala   +8 more
doaj   +1 more source

The Epitope-Specific Anti-human CD4 Antibody MAX.16H5 and Its Role in Immune Tolerance

Frontiers in Immunology, 2019
T cell modulation in the clinical background of autoimmune diseases or allogeneic cell and organ transplantations with concurrent preservation of their natural immunological functions (e.g., pathogen defense) is the major obstacle in immunology.
Lilly Stahl, Anna Duenkel, Nadja Hilger, Uta Sandy Tretbar, Stephan Fricke   +4 more
doaj   +1 more source

Expanding Role of Gastroenterologists in Acute Gastrointestinal Graft-versus-Host Disease: From Diagnosis and Management to Microbiome-Based Strategies

The Korean Journal of Gastroenterology
Acute graft-versus-host disease (GVHD) is a major complication following allogeneic hematopoietic stem cell transplantation. Steroid-refractory cases have poor outcomes, so an accurate diagnosis, particularly differentiation from cytomegalovirus colitis,
Seung Bum Lee
doaj   +1 more source

Donor leucocyte infusion

Journal of Bone Marrow Transplantation and Cellular Therapy
Donor-derived cellular therapies play a pivotal role in optimizing outcomes after allogeneic hematopoietic stem-cell transplantation (HCT). This article reviews three key post-transplant interventions: donor lymphocyte infusion (DLI), hematopoietic stem-
Adriana Martins de Sousa, Rita de Cassia Barbosa Tavares, Gil Cunha De Santis, Adriana Seber   +3 more
doaj   +1 more source

Azacytidine prevents experimental xenogeneic graft-versus-host disease without abrogating graft-versus-leukemia effects

OncoImmunology, 2017
The demethylating agent 5-azacytidine (AZA) has proven its efficacy in the treatment of myelodysplastic syndrome and acute myeloid leukemia. In addition, AZA can demethylate FOXP3 intron 1 (FOXP3i1) leading to the generation of regulatory T cells (Treg).
Grégory Ehx, Gilles Fransolet, Laurence de Leval, Stéphanie D'Hondt, Sophie Lucas, Muriel Hannon, Loïc Delens, Sophie Dubois, Pierre Drion, Yves Beguin, Stéphanie Humblet-Baron, Frédéric Baron   +11 more
doaj   +1 more source

Bilateral corneal ulceration in ocular graft-versus-host disease

, 2013
William Stevenson, Hasanain Shikari, Ujwala S Saboo, Francisco Amparo, Reza Dana Cornea Service, Massachusetts Eye and Ear Infirmary, Boston, MA, USA Purpose: To report on corneal ulceration in ocular graft-versus-host disease (GVHD). Methods: This was a
Dana R, Shikari H, Saboo US, Stevenson W, Amparo F   +4 more
core