Results 71 to 80 of about 155,675 (375)

Adult patients with Ph+ ALL benefit from conditioning regimen of medium‐dose VP16 plus CY/TBI

Hematological Oncology, Volume 40, Issue 5, Page 1041-1055, December 2022., 2022
Abstract The medium‐dose etoposide (VP16) added on cyclophosphamide (CY)/total body irradiation (TBI) is one of the intensified myeloablative conditioning regimens used in allogenic hematopoietic stem cell transplantation (allo‐HSCT) for acute lymphoblastic leukemia (ALL).
Mari Morita‐Fujita, Yasuyuki Arai, Tadakazu Kondo, Kaito Harada, Naoyuki Uchida, Takashi Toya, Yukiyasu Ozawa, Takahiro Fukuda, Shuichi Ota, Makoto Onizuka, Yoshinobu Kanda, Yumiko Maruyama, Satoru Takada, Toshiro Kawakita, Takahide Ara, Tatsuo Ichinohe, Takafumi Kimura, Yoshiko Atsuta, Shinichi Kako   +18 more
wiley   +1 more source

Achievement of Tolerance Induction to Prevent Acute Graft-vs.-Host Disease

Frontiers in Immunology, 2019
Acute graft-vs.-host disease (GVHD) limits the efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT), a main therapy to treat various hematological disorders.
Govindarajan Thangavelu, Bruce R. Blazar
doaj   +1 more source

In Silico Derivation of HLA-Specific Alloreactivity Potential from Whole Exome Sequencing of Stem Cell Transplant Donors and Recipients: Understanding the Quantitative Immuno-biology of Allogeneic Transplantation [PDF]

Frontiers in Immunology 2014. 5:529, 2014
Donor T cell mediated graft vs. host effects may result from the aggregate alloreactivity to minor histocompatibility antigens (mHA) presented by the HLA in each donor-recipient pair (DRP) undergoing stem cell transplantation (SCT). Whole exome sequencing has demonstrated extensive nucleotide sequence variation in HLA-matched DRP. Non-synonymous single
arxiv   +1 more source

BAT2 and BAT3 polymorphisms as novel genetic risk factors for rejection after HLA-related SCT. [PDF]

, 2014
The genetic background of donor and recipient is an important factor determining the outcome of allogeneic hematopoietic SCT (allo-HSCT). We applied whole-genome analysis to investigate genetic variants - other than HLA class I and II - associated with ...
Andreani M, Angius A, Bacchetta R., Bulfone A, Ciceri F, Fleischhauer K, Floris M, Gregori S, LA NASA, GIORGIO, Lucarelli G, Marktel S, Piras I. S, Roncarolo M. G, Testi M   +13 more
core   +1 more source

Designing for Degradation: Transient Devices Enabled by (Nano)Cellulose

Advanced Materials, EarlyView.
Recent progress in transient devices enabled by (nano)cellulosic materials is reviewed. Transiency mechanisms, advantages of nanocelluloses, and a suite of applications are discussed. A circular thinking approach coupled with life cycle assessment is applied to critically revisit the potential, advantages, and challenges of nanocellulose‐enabled ...
Lucas J. Andrew, Erlantz Lizundia, Mark J. MacLachlan   +2 more
wiley   +1 more source

CCR7 alterations associated with inferior outcome of adult T‐cell leukemia/lymphoma under mogamulizumab treatment

Hematological Oncology, Volume 40, Issue 5, Page 876-884, December 2022., 2022
Abstract Adult T‐cell leukemia/lymphoma (ATL) patients have a very poor prognosis. The humanized anti‐CCR4 therapeutic monoclonal antibody, mogamulizumab, is a key agent for ATL treatment. Our previous integrated molecular analysis demonstrated that among all the driver genes in ATL, CCR7 gene alterations were significantly associated with clinical ...
Yuma Sakamoto, Takashi Ishida, Ayako Masaki, Takayuki Murase, Eiichi Ohtsuka, Morishige Takeshita, Reiji Muto, Hiromi Iwasaki, Asahi Ito, Shigeru Kusumoto, Nobuaki Nakano, Masahito Tokunaga, Kentaro Yonekura, Yukie Tashiro, Shinsuke Iida, Atae Utsunomiya, Ryuzo Ueda, Hiroshi Inagaki   +17 more
wiley   +1 more source

Reduced intensity transplantation for primary immunodeficiency disorders [PDF]

, 2010
Studies so far indicate that reduced intensity transplantation (RIT) may have an important role in treating patients with primary immunodeficiency disease (PID).
Veys, Paul
core   +3 more sources

State‐of‐the‐Art, Insights, and Perspectives for MOFs‐Nanocomposites and MOF‐Derived (Nano)Materials

Advanced Materials, EarlyView.
Different approaches to MOF‐NP composite formation, such as ship‐in‐a‐bottle, bottle‐around‐the‐ship and in situ one‐step synthesis, are used. Owing to synergistic effects, the advantageous features of the components of the composites are beneficially combined, and their individual drawbacks are mitigated.
Stefanos Mourdikoudis, Subhajit Dutta, Saqib Kamal, Sergio Gómez‐Graña, Isabel Pastoriza‐Santos, Stefan Wuttke, Lakshminarayana Polavarapu   +6 more
wiley   +1 more source

Dendritic Cell Regulation of Graft-Vs.-Host Disease: Immunostimulation and Tolerance

Frontiers in Immunology, 2019
Graft-vs.-host disease (GVHD) remains a significant cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
Hongshuang Yu, Yuanyuan Tian, Ying Wang, Shin Mineishi, Yi Zhang, Yi Zhang   +5 more
doaj   +1 more source

Using Gene Editing Approaches to Fine-Tune the Immune System

Frontiers in Immunology, 2020
Genome editing technologies not only provide unprecedented opportunities to study basic cellular system functionality but also improve the outcomes of several clinical applications.
Kristina Pavlovic, Kristina Pavlovic, María Tristán-Manzano, Noelia Maldonado-Pérez, Marina Cortijo-Gutierrez, Sabina Sánchez-Hernández, Pedro Justicia-Lirio, Pedro Justicia-Lirio, M. Dolores Carmona, Concha Herrera, Concha Herrera, Francisco Martin, Karim Benabdellah   +12 more
doaj   +1 more source