Results 11 to 20 of about 4,412,822 (263)

Harnessing Gram‐negative bacteria for novel anti‐Gram‐negative antibiotics

Microbial Biotechnology
Natural products have proven themselves as a valuable resource for antibiotics. However, in view of increasing antimicrobial resistance, there is an urgent need for new, structurally diverse agents that have the potential to overcome resistance and treat
Joy Birkelbach, Carsten E. Seyfert, Sebastian Walesch, Rolf Müller   +3 more
doaj   +2 more sources

A Cyclic Di-GMP Network Is Present in Gram-Positive Streptococcus and Gram-Negative Proteus Species [PDF]

, 2020
Cyclic di-GMP is a ubiquitous second messenger in bacteria. This work describes the occurrence of a cyclic di-GMP signaling network in Gram-positive Streptococcus species and Gram-negative Proteus.
Rey-Ting, Guo, Changhan, Lee, Heike, Bähre, Ute, Romling, Ying, Liu, Chun-Chi, Chen, Alexey, Chernobrovkin, Fengyang, Li, Janja, Trček, Roman, Zubarev   +9 more
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Prevalence of multiresistant gram-negative organisms in a tertiary hospital in Mwanza, Tanzania. [PDF]

, 2009
\ud Antimicrobial resistance is fast becoming a global concern with rapid increases in multidrug-resistant Gram negative organisms. The prevalence of extended spectrum beta-lactamase (ESBL)-producing clinical isolates increases the burden on implementing
Kamugisha, Erasmus, Chakraborty Trinad, Mirambo Mariam, Mshana, S.E., Mirambo, M., Stephen E Mshana, Mariam Mirambo, Kamugisha Erasmus, Erasmus Kamugisha, Mshana Stephen E, Lyamuya Eligius F, Mirambo, Mariam, Lyamuya, Eligius F, Eligius F Lyamuya, Chakraborty, T., Chakraborty, Trinad, Lyamuya, E.F., Mshana, Stephen E, Kamugisha, E., Trinad Chakraborty   +19 more
core   +1 more source

Vancomyxins: Vancomycin-Polymyxin Nonapeptide Conjugates That Retain Anti-Gram-Positive Activity with Enhanced Potency against Gram-Negative Strains

, 2021
Vancomycin functions by binding to lipid II, the penultimate bacterial cell wall building block used by both Gram-positive and Gram-negative species.
Paolo Innocenti (228808), Nathaniel I. Martin, Emma van Groesen, Emma van Groesen (11417127), Milos Mihajlovic (11417130), Rosalinde Masereeuw (180563), Cornelis J. Slingerland, Rosalinde Masereeuw, Milos Mihajlovic, Paolo Innocenti, Cornelis J. Slingerland (2796262), Nathaniel I. Martin (847378)   +11 more
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Cytoplasmic accumulation and permeability of antibiotics in Gram positive and Gram negative bacteria visualized in real-time via a fluorogenic tagging strategy [PDF]

, 2023
In this study, we describe a real-time live cell assay for compound accumulation and permeability in both Gram positive and Gram negative bacteria. The assay utilizes a novel fluorogenic tagging strategy that permits direct visualization of compound ...
Scott, Squire, Sepehr, Sebghati, Ming, Hammond   +2 more
core   +2 more sources

Antimicrobial resistance characteristics and fitness of Gram-negative fecal bacteria from volunteers treated with minocycline or amoxicillin. [PDF]

, 2014
A yearlong study was performed to examine the effect of antibiotic administration on the bacterial gut flora. Gram-negative facultative anaerobic bacteria were recovered from the feces of healthy adult volunteers administered amoxicillin, minocycline or ...
Theresa eHunt, Javier eNunez-Garica, Miranda eKirchner, Miranda Kirchner, Yanmin Hu, Weile, J, Anthony Coates, Javier Nunez-Garcia, Card, R, Anjum, MF, Theresa Hunt, Roderick Card, Jan Weile, Kirchner, M, Mafura, M, Muriel eMafura, Hunt, T, Abu-Oun, M, Muna eAnjum, Roderick eCard, Muriel Mafura, Manal eAbuoun, Muna F. Anjum, Hu, Y, Nunez-Garcia, J, Yanmin eHu, Manal Abu-Oun, Jan eWeile, Anthony eCoates, Coates, A   +29 more
core   +1 more source

Hot-spot consensus of fluoroquinolone-mediated DNA cleavage by gram-negative and gram-positive type II DNA topoisomerases [PDF]

, 2007
Bacterial DNA gyrase and topoisomerase IV are selective targets of fluoroquinolones. Topoisomerase IV versus gyrase and Gram-positive versus Gram-negative behavior was studied based on the different recognition of DNA sequences by topoisomerase ...
GIARETTA G, COMUZZI V, Palumbo, M, Leo, E, Mitchenall, LA, Richter, SN, Maxwell, A, Fisher, LM, RICHTER, SARA, Giaretta, G, LEO E, MAXWELL A, Comuzzi, V, FISHER LM, MITCHENALL LA, PALUMBO, MANLIO   +15 more
core   +1 more source

Efficiency of “Biolide” disinfectant working solutions for action on gram-negative and gram-positive bacteria

, 2021
The article presents the results of the new developed disinfectant “Biolide” research for use in poultry and other sectors of agriculture, because today the problem of developing cheap and effective disinfectants remains relevant.
O. I. Gorbatyuk, T. O. Garkavenko, V. L. Kovalenko, O. N. Chechet, T. H. Kozytska   +4 more
core   +1 more source

Red-shifted environmental fluorophores and their use for the detection of Gram-negative bacteria_raw spectral data

, 2021
Spectral data (absorption, fluorescence, lifetime) of merocyanine derivatives described in the research article entitled "Red-shifted environmental fluorophores and their use for the detection of Gram-negative bacteria" published in Chemosensors (2021 ...
Dhaliwal, Kevin, Bradley, Mark, Megia-Fernandez, Alicia, Brown, Gillian E., McEwan, Heather, Klausen, Maxime, Mills, Beth, Finlayson, Neil   +7 more
core   +1 more source

Granulocyte-activating mediators (GRAM) [PDF]

, 1987
In the present study we investigated the capability of human epidermal cells to generate granulocyte-activating mediators (GRAM). It could be shown that human epidermal cells as well as an epidermoid carcinoma cell line (A431) produce an epidermal cell ...
Kapp, A., Zeck-Kapp, G., Möller, A., Putz, Reinhard, A. Kapp, E. Sch�pf, T. A. Luger, C. Hauser, M. Danner   +8 more
core   +1 more source