Results 41 to 50 of about 4,412,822 (263)

The Hospital Environment as a Source of Resistant Gram Negatives

, 2014
Presented at the ASID Gram Negative 'Superbugs' Meeting, 2-3 Aug. 2013.
Mitchell, Brett G.
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Antimicrobial Effect of Acacia Nilotica on Some Gram Positive and Gram Negative Bacteria

Al-Mustansiriyah Journal of Science, 2018
Acacia nilotica is a plant has an inspiring range of medicinal uses. This plant contributes a number of groups among which are alkaloids, volatile essential oils, phenols and phenolic glycosides, resins, oleosins, steroids, tannins and terpenes, this ...
Faten R. Hameed
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

High genetic relatedness between multidrug resistant bacteria before and after the 2022 invasion of Ukraine

Genome Medicine
Background The Russian invasion of Ukraine in 2022 has placed extraordinary pressure on hospitals there. One consequence of this has been the alarming increase in infections caused by multi-drug resistant organisms (MDROs), both within Ukraine and among ...
Francois Lebreton, Viacheslav Kondratiuk, Valentyn Kovalchuk, Niels Pfennigwerth, Ting L. Luo, Brendan T. Jones, Nadiia Fomina, Frieder Fuchs, Jörg B. Hans, Jessica Eisfeld, Ana Ong, Sören Gatermann, Jason W. Bennett, Patrick Mc Gann   +13 more
doaj   +1 more source

One Health genomic surveillance of Klebsiella pneumoniae in Belgium demonstrates large genomic diversity, presence of ESBLs and carbapenemases and circulation of clones across sectors

Frontiers in Microbiology
Klebsiella pneumoniae is an important reservoir and disseminator of antimicrobial resistance (AMR) genes. Multidrug-resistant lineages, particularly extended-spectrum β-lactamase (ESBL)-producing and carbapenem-resistant strains, represent an important ...
Hanne Debergh, Hanne Debergh, Bert Bogaerts, Inge Van Damme, Cécile Boland, Kevin Vanneste, Koenraad van Hoorde, Pierre Bogaerts, Te-Din Huang, Marc Saulmont, Nadine Botteldoorn, Claude Saegerman, Cristina Garcia-Graells   +12 more
doaj   +1 more source

Treatment of Multi-Drug Resistant Gram-Negative Bacterial Pathogenic Infections

, 2020
The multidrug-resistant Gram-negative bacteria (MDR-GNB) infections in severely infected patients present numerous difficulties in terms of treatment failure where antibiotics cannot arrest such drug resistant bacteria.
Ahmed Mohamed Ahmed, Godfred Antony Menezes, Wardah Mohammad Akram, Nida Abbas, Wasim Ahmad   +4 more
core   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source