Results 101 to 110 of about 102,482 (316)
Gauge-Higgs Seesaw Mechanism in Six-Dimensional Grand Unification
, 2017 $SO(11)$ gauge-Higgs grand unification is formulated in the six-dimensional hybrid warped space in which the fifth and sixth dimensions play as the electroweak and grand-unification dimensions.
Hosotani, Yutaka, Yamatsu, Naoki
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
The gauge coupling evolutions of an SU(8) theory with the maximally symmetry breaking pattern
Journal of High Energy PhysicsWe study the renormalizable group equations (RGEs) of the extended strong and weak gauge couplings in an SU(8) theory, where three-generational SM fermions are non-trivially embedded.
Ning Chen +3 more
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
A modular SU (5) littlest seesaw
Journal of High Energy PhysicsWe extend the littlest modular seesaw to a Grand Unified scenario based on SU (5) endowed with three modular S 4 symmetries. We leverage symmetry protected zeroes in the leptonic and down quark sectors to suppress deviations to the littlest modular ...
Ivo de Medeiros Varzielas +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Spontaneous CP violation and leptogenesis in SO(10)
Journal of High Energy PhysicsWe present a renormalizable SO(10) grand unified theory with a minimal Yukawa sector consisting of a 126 H , a real 10 H and a real 120 H , where CP violation has a spontaneous origin.
K. S. Babu, Chee Sheng Fong, Shaikh Saad
doaj +1 more source
Search for Z′, vacuum (in)stability and hints of high-energy structures
EPJ Web of Conferences, 2016 We study the high-energy behaviour of a class of anomaly-free abelian extensions of the Standard Model. We focus on the interplay among the phenomenological characterisation of the model and the use of precise renormalisation group methods.
Accomando Elena +5 more
doaj +1 more source