Results 41 to 50 of about 102,482 (316)

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Grand unification through gravitational effects [PDF]

, 2010
We systematically study the unification of gauge couplings in the presence of (one or more) effective dimension-5 operators cHGG/4MPl, induced into the grand unified theory by gravitational interactions at the Planck scale MPl.
David Reeb, G.’t Hooft, H. Georgi, M. Shiozawa, Stephen D. H. Hsu, Xavier Calmet   +5 more
core   +2 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Fermion masses and mixings in supersymmetric SO(10) with third-generation quasi-Yukawa unification

Journal of High Energy Physics
We discuss the charged and neutral fermion masses and mixings in a supersymmetric SO(10) model with a minimal Higgs sector consisting of the multiplets 10 H , 45 H , and $${16}_{H}+{\overline{16} }_{H}$$ .
Shaikh Saad, Qaisar Shafi
doaj   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Grand unification, small vs large representations, hadron colliders and all that [PDF]

, 2023
Goran Senjanović, Michael Zantedeschi
openalex   +1 more source

Grand Unification at Intermediate Mass Scales through Extra Dimensions [PDF]

, 1998
One of the drawbacks of conventional grand unification scenarios has been that the unification scale is too high to permit direct exploration. In this paper, we show that the unification scale can be significantly lowered (perhaps even to the TeV scale ...
Abel, Antoniadis, Antoniadis, Antoniadis, Antoniadis, Antoniadis, Babu, Banks, Banks, Brandenberger, Burgess, Caceres, del Aguila, Demichev, Dienes, Dienes, Dienes, Dienes, Dixon, Dudas, Dudas, Emilian Dudas, Froggatt, Gherghetta, Ghilencea, Hempfling, Hořava, Kane, Kaplunovsky, Kaplunovsky, Keith R. Dienes, Kiritsis, Kiritsis, Kirsten, Kolb, Kolda, Kostelecky, Lykken, Rubakov, Scherk, Taylor, Tony Gherghetta, Witten   +42 more
core   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Probing grand unification with quantum sensors

Physics Letters B
We discuss how grand unification can be probed with experiments at low energies using quantum sensors. Specifically, we show that scalar multiplets coupled to the gauge sector of a grand unified theory provide a mechanism for a time-varying unified ...
Xavier Calmet, Nathaniel Sherrill
doaj   +1 more source

Nilpotent symmetries as a mechanism for Grand Unification

Journal of High Energy Physics, 2021
In the classic Coleman-Mandula no-go theorem which prohibits the unification of internal and spacetime symmetries, the assumption of the existence of a positive definite invariant scalar product on the Lie algebra of the internal group is essential.
Lars Andersson, András László, Błażej Ruba   +2 more
doaj   +1 more source