Results 1 to 10 of about 10,360,699 (193)
eLife, 2023 An in vitro model of human ovarian follicles would greatly benefit the study of female reproduction. Ovarian development requires the combination of germ cells and several types of somatic cells.
Merrick D Pierson Smela +13 more
doaj +2 more sources
Interaction between growing oocytes and granulosa cells in vitro
Reproductive Medicine and Biology, 2020 Background Oocyte growth is accompanied by follicular development in mammalian ovaries. Since the discovery of two oocyte‐derived factors, growth differentiation factor 9 (GDF9), and bone morphogenetic protein 15 (BMP15), knowledge of the bidirectional ...
Md Hasanur Alam, Takashi Miyano
doaj +2 more sources
Cellular and exosome mediated molecular defense mechanism in bovine granulosa cells exposed to oxidative stress. [PDF]
PLoS ONE, 2017 Various environmental insults including diseases, heat and oxidative stress could lead to abnormal growth, functions and apoptosis in granulosa cells during ovarian follicle growth and oocyte maturation.
Mohammed Saeed-Zidane +8 more
doaj +2 more sources
TGF-β1 Up-Regulates Connective Tissue Growth Factor Expression in Human Granulosa Cells through Smad and ERK1/2 Signaling Pathways. [PDF]
PLoS ONE, 2015 Connective tissue growth factor (CTGF), which is also called CCN2, is a secreted matricellular protein. CTGF regulates various important cellular functions by interacting with multiple molecules in the microenvironment.
Jung-Chien Cheng +4 more
doaj +2 more sources
PLoS ONE, 2015 In studies using isolated ovarian granulosa and thecal cells it is important to assess the degree of cross contamination. Marker genes commonly used for granulosa cells include FSHR, CYP19A1 and AMH while CYP17A1 and INSL3 are used for thecal cells.
Nicholas Hatzirodos +3 more
doaj +2 more sources
Mechanisms of and Potential Medications for Oxidative Stress in Ovarian Granulosa Cells: A Review
International Journal of Molecular Sciences, 2023 Granulosa cells are essential for follicle initiation and development, and their abnormal function or apoptosis is a crucial factor leading to follicular atresia.
Siheng Liu +5 more
semanticscholar +1 more source
Cell Death and Disease, 2022 In mammals, nonrenewable primordial follicles are activated in an orderly manner to maintain the longevity of reproductive life. Mammalian target of rapamycin (mTOR)-KIT ligand (KITL) signaling in pre-granulosa cells and phosphatidylinositol 3-kinase ...
Xiaodan Zhang +10 more
semanticscholar +1 more source
Dynamic transcriptome and chromatin architecture in granulosa cells during chicken folliculogenesis
Nature Communications, 2022 Folliculogenesis is a complex biological process involving a central oocyte and its surrounding somatic cells. Three-dimensional chromatin architecture is an important transcription regulator; however, little is known about its dynamics and role in ...
Diyan Li +17 more
semanticscholar +1 more source
Luzindole and 4P-PDOT block the effect of melatonin on bovine granulosa cell apoptosis and cell cycle depending on its concentration [PDF]
PeerJ, 2021 Granulosa cells play an essential physiological role in mediating the follicle development and survival or apoptosis of granulosa cells dictate the follicle development or atresia.
Shujuan Wang +4 more
doaj +2 more sources
Unicystic Granulosa Cell Tumor [PDF]
Journal of Pathology and Translational Medicine, 2015 Granulosa cell tumors are the most frequent sex cord stromal tumor and account for approximately 5% of all primary ovarian tumors. About 5% occur before puberty and 40% occur in the menopausal age group; however, these tumors have an indolent biological behavior [1].
Arun Prabhakaran +3 more
openaire +3 more sources