PRMT5 regulates ovarian follicle development by facilitating Wt1 translation
eLife, 2021 Protein arginine methyltransferase 5 (Prmt5) is the major type II enzyme responsible for symmetric dimethylation of arginine. Here, we found that PRMT5 was expressed at high level in ovarian granulosa cells of growing follicles.
Min Chen +8 more
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OAZ1 knockdown enhances viability and inhibits ER and LHR transcriptions of granulosa cells in geese. [PDF]
PLoS ONE, 2017 An increasing number of studies suggest that ornithine decarboxylase antizyme 1 (OAZ1), which is regarded as a tumor suppressor gene, regulates follicular development, ovulation, and steroidogenesis.
Bo Kang +5 more
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The Cultivation of Human Granulosa Cells [PDF]
Acta Medica (Hradec Kralove, Czech Republic), 2008 The major functions of granulosa cells (GCs) include the production of steroids, as well as a myriad of growth factors to interact with the oocyte during its development within the ovarian follicle. Also FSH stimulates GCs to convert androgens (coming from the thecal cells) to estradiol by aromatase.
Benjamin Visek +7 more
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Journal of Ovarian Research, 2020 Background The complex regulatory mechanism involved in ovarian follicular development is not completely understood. Neuronal neuropeptide Y (NPY) is involved in the regulation of feeding behavior, energy homeostasis, and reproduction behavior, while its
Yoko Urata +4 more
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Inductions of granulosa cell luteinization and cumulus expansion are dependent on the fibronectin-integrin pathway during ovulation process in mice. [PDF]
PLoS ONE, 2018 It has been known that EGF-like factor secreted from LH-stimulated granuloma cells acts on granulosa cells and cumulus cells to induce ovulation process.
Hiroya Kitasaka +5 more
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Isolation of Human Cumulus Granulosa Cells
Van Tıp Dergisi, 2022 INTRODUCTION: Follicles are the basic functional units of the ovary. It is characterized by the growth and development of ovarian follicles, proliferation and differentiation of granulosa cells.
Murat Serkant Ünal, Cihan Kabukçu
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SUMOylation of mouse p53b by SUMO-1 promotes its pro-apoptotic function in ovarian granulosa cells. [PDF]
PLoS ONE, 2013 Follicular atresia is a process of spontaneous degradation of follicles, hindering growth and development in the mammalian ovary. Previous studies showed that follicular atresia was caused by apoptosis of granulosa cells, for which a number of apoptosis ...
Xiao-Ming Liu +4 more
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BCAS2 regulates granulosa cell survival by participating in mRNA alternative splicing
Journal of Ovarian Research, 2023 Background Granulosa cell proliferation and differentiation are essential for follicle development. Breast cancer amplified sequence 2 (BCAS2) is necessary for spermatogenesis, oocyte development, and maintaining the genome integrity of early embryos in ...
Xiaohong Yao +11 more
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Aquaporin-8 transports hydrogen peroxide to regulate granulosa cell autophagy
Frontiers in Cell and Developmental Biology, 2022 Aquaporin-8 (AQP8), a member of the aquaporin family, is strongly expressed in follicular granulosa cells, which could affect the hormone secretion level in females.
Binbin Huang +9 more
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Effect of Vitamin D3 on Mitochondrial Biogenesis in Granulosa Cells Derived from Polycystic Ovary Syndrome [PDF]
International Journal of Fertility and Sterility, 2020 Background Polycystic ovary syndrome (PCOS) is an endocrine disorder diagnosed by anovulation hyperandro- genism. Hyperandrogenism increases apoptosis, which will eventually disturb follicular growth in PCOS patients.
Zahra Safaei +6 more
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