Results 131 to 140 of about 3,866 (172)

Enhancing NK Cell Activity in Colorectal Cancer with an Fc-Optimized Antibody Targeting CD276 (B7-H3). [PDF]

Immunotargets Ther
Stefańczyk SA, Kaiser X, Hagelstein I, Lutz MS, Holzmayer SJ, Zekri L, Märklin M, Jung S.   +7 more
europepmc   +1 more source

iPSC-derived NK cells engineered with CD226 effectively control acute myeloid leukemia. [PDF]

Exp Hematol Oncol
Cai R, Lu B, Zhao X, Zhou S, Li Y.
europepmc   +1 more source

Comparative Analysis of Extracellular Vesicles from Cytotoxic CD8⁺ αβ T Cells and γδ T Cells. [PDF]

Cells
Griesel L, Kaleja P, Tholey A, Lettau M, Janssen O.   +4 more
europepmc   +1 more source

Granulysin antimicrobial activity promotes dormancy in Mycobacterium tuberculosis

Schmidiger S, McCaffrey EF, Schmidt JM, Hameed OA, Mpina M, Tumbo A, Mfinanga E, Haraka F, Hiza H, Sasamalo M, Hella J, Walch M, Fellay J, Gagneux S, Reither K, Carballido JM, Arbués A, Portevin D.   +17 more
europepmc   +1 more source

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The multifaceted granulysin

Blood, 2010
Abstract Granulysin is a cytolytic and proinflammatory peptide contained in the cytotoxic granules of NK cells and CTL. Unexpectedly, granulysin also recruits and activates dendritic cells via TLR4/Myd88, playing the role of an immune adjuvant. Hence, in contrast to classical alarmins released by early leukocytes, granulysin is the first
Guido Kroemer, Zitvogel Laurence
exaly   +3 more sources

Granulysin: a novel antimicrobial

Expert Opinion on Investigational Drugs, 2001
Granulysin is a novel lytic molecule produced by human cytolytic T-lymphocytes (CTLs) and natural killer (NK) cells. It is active against a broad range of microbes, including Gram-positive and -negative bacteria, parasites and Mycobacterium tuberculosis.
Satoshi Okada, Alan M Krensky, Carol Clayberger   +2 more
exaly   +3 more sources

Granulysin: a lethal weapon of cytolytic T cells

Trends in Immunology, 1999
Abstract CD8 + T cells protect against infection from intracellular bacteria and parasites by lysing infected targets. Here, a novel mechanism is discussed in which CD8 + cytolytic T cells directly destroy intracellular pathogens by releasing an antimicrobial protein, granulysin, from cytotoxic granules.
Steffen Stenger, Robert Modlin, Alan M Krensky   +2 more
exaly   +3 more sources

Differential expression of granulysin and perforin by NK cells in cancer patients and correlation of impaired granulysin expression with progression of cancer

Cancer Immunology, Immunotherapy, 2002
Granulysin has been identified as an effector molecule co-localized with perforin in the cytotoxic granules of cytotoxic T lymphocytes and natural killer (NK) cells, and has been reported to kill intracellular pathogens in infected cells in the presence of perforin and to induce a cytotoxic effect against tumor cells.
Atsuko, Kishi, Yasushi, Takamori, Kazuyuki, Ogawa, Shoichi, Takano, Shuji, Tomita, Mari, Tanigawa, Makiko, Niman, Tsunataro, Kishida, Setsuya, Fujita   +8 more
exaly   +3 more sources

Granulysin

Current Opinion in Immunology, 2003
Granulysin, a molecule expressed by human natural killer cells and activated T lymphocytes, exhibits cytolytic activity against a variety of microbes and tumors. Progress in understanding the structure, function and clinical relevance of granulysin over the past year encompasses three main areas: first, the solution of its crystal structure, providing ...
Carol, Clayberger, Alan M, Krensky
openaire   +2 more sources