Results 91 to 100 of about 94,825 (337)
Granzymes in health and diseases: the good, the bad and the ugly
Frontiers in ImmunologyGranzymes are a family of serine proteases, composed of five human members: GA, B, H, M and K. They were first discovered in the 1980s within cytotoxic granules released during NK cell- and T cell-mediated killing.
Lavinia Cigalotto +3 more
doaj +1 more source
Asp-ase Activity of the Opossum Granzyme B Supports the Role of Granzyme B as Part of Anti-Viral Immunity Already during Early Mammalian Evolution. [PDF]
PLoS ONE, 2016 Granzyme B is one of the key effector molecules in our defense against viruses and intracellular bacteria. This serine protease together with the pore forming protein perforin, induces caspase or Bid-dependent apoptosis in target cells.
Zhirong Fu +3 more
doaj +1 more source
Cell Death and Disease, 2019 Cytotoxic T lymphocytes (CTL) and natural killer cells (NK)-mediated elimination of tumor cells is mostly dependent on Granzyme B apoptotic pathway, which is regulated by the wild type (wt) p53 protein.
Marie Chollat-Namy +5 more
semanticscholar +1 more source
Granzymes in cancer and immunity [PDF]
Cell Death & Differentiation, 2010 Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells are indispensable factors in the body's ongoing defence against viral infection and tumor development. CTL/NK cells recognize and kill infected or aberrant target cells by two major pathways: either through introduction of a battery of proteases - called granzymes - to the target cell cytosol,
S P, Cullen, M, Brunet, S J, Martin
openaire +2 more sources
Advanced Science, EarlyView.IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang +15 more
wiley +1 more source
LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1
Advanced Science, EarlyView.LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li +12 more
wiley +1 more source
Structure and evolutionary origin of the human granzyme H gene [PDF]
, 2017 Among the molecules proposed to be involved In cytotoxic T lymphocyte (CTL), natural killer (NK) and lymphokine activated killer (LAK) cell-mediated lysis are the granzymes, a family of serine proteases stored in the cytoplasmic granules of CTLs, NK and ...
Clément, Marie-Véronique +5 more
core
G-Protein Coupled Receptor 18 Contributes to Establishment of the CD8 Effector T Cell Compartment. [PDF]
, 2018 The requirements for effector and memory CD8 T cell development are incompletely understood. Recent work has revealed a role for G-protein coupled receptor 18 (GPR18) in establishment of the intestinal CD8αα intraepithelial lymphocyte compartment.
Cyster, Jason G, Sumida, Hayakazu
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Expression of intra- and extracellular granzymes in patients with typhoid fever.
PLoS Neglected Tropical Diseases, 2017 BackgroundTyphoid fever, caused by the intracellular pathogen Salmonella (S.) enterica serovar Typhi, remains a major cause of morbidity and mortality worldwide.
Hanna K de Jong +8 more
doaj +1 more source
A quarter century of granzymes [PDF]
Cell Death & Differentiation, 2011 Granzymes (Grs) were discovered just over a quarter century ago. They are produced by cytotoxic T cells and natural killer cells and are released upon interaction with target cells. Intensive biochemical, genetic, and biological studies have been performed in order to study their roles in immunity and inflammation.
C L, Ewen, K P, Kane, R C, Bleackley
openaire +2 more sources