Results 241 to 250 of about 94,825 (337)

Quinovic Acid Enhances the Cytotoxicity of KHYG-1 Cells by Modulating the Ras/MAPK Signalling Pathway and Interferon-Gamma Expression. [PDF]

J Cell Mol Med
Hsieh MJ, Lin JT, Chuang YC, Ho HY, Lo YS, Lin CC, Chen MK.   +6 more
europepmc   +1 more source

Intradermal immunization with Plasmodium berghei late-arresting genetically attenuated sporozoites induces PD-L1 expression on regulatory macrophages and dendritic cells. [PDF]

Sci Rep
van Schuijlenburg R, Naar CM, de Bes-Roeleveld HM, Chevalley-Maurel S, Zigó LA, Houlder EL, Lambooij JM, Baalbergen E, Roestenberg M, Franke-Fayard B.   +9 more
europepmc   +1 more source

Multiphysics‐Driven Assembly of Biomimetic Vesicles

Advanced Materials, Volume 38, Issue 13, 3 March 2026.
Artificial extracellular vesicles, derived from cell membranes, are manufactured using a multiphysics‐integrated microfluidic platform that combines nanoknife membrane rupture, herringbone chaotic mixing, and acoustothermal modulation. This standardizable workflow enables the predictable control of vesicle formation and therapeutic loading, while ...
Timofei Solodko, Ian Gimino, Aastha Chandiwala, Bayan Alkotoub, Ali Bashiri Dezfouli, Heiko Reith, Asjad Bakhtiar, Rojda Hicsanmaz, Johann Brenner, Christoph J. O. Kaiser, Elena Belli, Shilpi Pandey, Samuel D. Rabkin, Kornelius Nielsch, Gabriele Multhoff, Oliver Hayden, Morteza Hasanzadeh Kafshgari   +16 more
wiley   +1 more source

Serum and CSF cytokine profile in patients with facial palsy (Bell's palsy): a pilot study. [PDF]

J Neurol
Ustinov A, Heckmann JG, Singh V, Arneth B, Schwab S.   +4 more
europepmc   +1 more source

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source

Effect of Curcuma Longa Extract to Granzyme Expression and Tumor Mass Diameter of Mammary Adenocarcinoma with Chemotherapy Adriamycin Cyclophosphamide: An Animal Study in Rats. [PDF]

Asian Pac J Cancer Prev
Nugroho BE, Budijitno S, Prajoko YW, Susilaningsih N, Mahati E, Muniroh M, Alwi L, Putra SP.   +7 more
europepmc   +1 more source

Antiemesis Corticosteroids Potentiate Checkpoint Blockade Efficacy by Normalizing the Immune Microenvironment in Metastatic Murine Breast Cancer

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Corticosteroids improve the efficacy of immune checkpoint blockade therapy in metastatic murine breast cancer. By normalizing the tumor immune microenvironment, corticosteroids reduce immunosuppressive signals, restore T‐cell function, and promote antitumor immune responses, resulting in enhanced tumor control.
John D. Martin, Koji Nagaoka, Myrofora Panagi, Akihiro Hosoi, Fotios Mpkeris, Pengwen Chen, Thahomina T. Khan, Margaret R. Martin, Changbo Sun, Chrysovalantis Voutouri, Maria Louca, Panagiotis Papageorgis, Akira Sumiyoshi, Nobuhiro Nitta, Kazuyoshi Takeda, Ichio Aoki, Kazunori Kataoka, Triantafyllos Stylianopoulos, Kazuhiro Kakimi, Horacio Cabral   +19 more
wiley   +1 more source

Immune checkpoint TIM-3 defines hyperactivated NK cells and predicts fatal outcome in severe fever with thrombocytopenia syndrome. [PDF]

PLoS Negl Trop Dis
Qian X, Zhang Y, Cheng Z, Song H, Huang L, Jia B, Li J, Wang J, Wu W.   +8 more
europepmc   +1 more source

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, Volume 13, Issue 14, 9 March 2026.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

Metabolic characterization of tumor-immune interactions by multiplexed immunofluorescence reveals spatial mechanisms of immunotherapy response in non-small cell lung carcinoma (NSCLC). [PDF]

Nat Commun
Monkman J, Kilgallon A, Lawler C, Tubelleza R, Aung TN, Warrell JH, Vathiotis I, Trontzas IP, Gavrielatou N, Nyein Chan NN, Czertok R, Bookstein S, O'Byrne K, Markovits E, Rimm DL, Kulasinghe A.   +15 more
europepmc   +1 more source