Results 261 to 270 of about 94,825 (337)

Engineered CAR‐NKT Extracellular Vesicles Suppress Tumor Progression and Enhance Antitumor Immunity

Advanced Science, Volume 13, Issue 13, 3 March 2026.
TM4SF1‐nanobody engineered CAR‐natural killer T–derived extracellular vesicles (CARTM4SF1‐EVs) provide a cell‐free alternative to CAR‐NKT therapy, achieving potent, targeted antitumor activity with reduced toxicity. CARTM4SF1‐EVs induce immunogenic cell death, remodel the tumor microenvironment, and enhance CD8⁺ T‐cell antitumor immunity.
Xiaopei Hao, Chengming Qu, Yanzhao Zhou, Xiaoqian Wang, Xiangjun Qian, Xun Chen, Feng Han, Xiaokai Zhang, Yiyi Ji, Han Li, ChengWei Ju, Peng Xia, Weiwei Tang, Hao Zhuang, Jinxue Zhou   +14 more
wiley   +1 more source

Development and evaluation of an inhalable nanoemulsion system for enhancing NK cell function against osteosarcoma pulmonary metastases. [PDF]

Front Immunol
Hwang S, Bates PD, Valkanioti V, Chang CC, Mecozzi S, Capitini CM.   +5 more
europepmc   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Gut microbial metabolite butyrate boosts p53-expressing telomerase-specific oncolytic adenovirus efficacy by enhancing infectivity and activating MHC-I/cGAS-STING. [PDF]

Cancer Immunol Immunother
Sakamoto M, Kuroda S, Katayama T, Mikane Y, Hanzawa S, Kadowaki D, Yoshida Y, Hamada Y, Sugimoto R, Yagi C, Hashimoto M, Kanaya N, Kakiuchi Y, Kikuchi S, Shigeyasu K, Tazawa H, Kagawa S, Urata Y, Fujiwara T.   +18 more
europepmc   +1 more source

Prognostic Impact of Immunoscore in Pathological Stage III Differentiated Gastric Cancer: A Multicenter Cohort Study Including PD‐L1/PD‐L2 Expression Analysis

Annals of Gastroenterological Surgery, Volume 10, Issue 2, Page 431-442, March 2026.
We assessed the prognostic ability of the Immunoscore and PD‐L1 or PD‐L2 expression in pStage III GC patients by immunohistochemistry. The results showed that Immunoscore was an independent prognostic factor in differentiated GC, but not in undifferentiated GC.
Yoshiro Yukawa, Takuro Saito, Yukinori Kurokawa, Yusuke Akamaru, Shinya Kidogami, Hiroshi Imamura, Kazumasa Fujitani, Jin Matsuyama, Kazuyoshi Yamamoto, Tsuyoshi Takahashi, Takahiro Matsui, Eiichi Morii, Hidetoshi Eguchi, Yuichiro Doki   +13 more
wiley   +1 more source

Histopathological Characterization and Differential Expression of miRNAs in Male Pediatric Patients With Lichen Sclerosus. [PDF]

Andrology
Flammang V, Hartmann A, Stöhr R, Weigelt K, Geppert C, Stuebs FA, Beckmann MW, Wullich B, Taubert H, Marcou M, Wach S.   +10 more
europepmc   +1 more source

Study on the Function and Mechanism of Neutrophil Extracellular Traps in Regulating Necroptosis Following Traumatic Brain Injury

Brain and Behavior, Volume 16, Issue 3, March 2026.
TBI induces NETs formation, as evidenced by the upregulation of PAD4 and MPO. NETs activate the necroptosis pathway via phosphorylation of RIP1‐RIP3‐MLKL, thereby exacerbating secondary brain injury (neuronal death, BBB disruption, and neuroinflammation).
Ao Li, Tian‐Wei Pei, Hao Qi, Li‐Biao Song, Juan Fang, Zhi‐Song Ding, Tao Chen   +6 more
wiley   +1 more source

The application and prospect of granzyme B-targeted PET imaging in cancer immunotherapy. [PDF]

J Transl Med
Tong X, Jiang Y, Bi N.
europepmc   +1 more source

SLC12A8 Drives Immune Evasion and Metastasis in Luminal B Breast Cancer by Inducing CD8+ T‐Cell Exhaustion via the TLR Signaling Pathway

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background To investigate the role and mechanism of SLC12A8 in the progression of Luminal B breast cancer. Methods Data from TCGA, GTEx, and HPA databases were used to analyze SLC12A8 expression and its prognostic value in breast cancer. qPCR was performed to validate SLC12A8 expression in various breast cancer cell lines.
Zhiyong Liu, Ran Chen
wiley   +1 more source