Results 281 to 290 of about 94,825 (337)
Simultaneous efficacy of IL-15 and the HSP70 fragments in increasing immunostimulatory effects of a HIV-1 DNA vaccine candidate against SCR HIV-1. [PDF]
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Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells
Science, 2020Granzyme A lights a fire Cytotoxic T cells and natural killer cells use several strategies to kill infected or transformed cells. One such pathway entails the delivery of a family of serine proteases called granzymes to target cells through perforin ...
Zhiwei Zhou, Huabin He, Yupeng Wang
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Functional significance of the perforin/granzyme cell death pathway
Nature Reviews Immunology, 2002Joseph A Trapani, Mark J Smyth
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Granzyme K+ CD8 T cells form a core population in inflamed human tissue
Science Translational Medicine, 2022T cell–derived pro-inflammatory cytokines are a major driver of rheumatoid arthritis (RA) pathogenesis. Although these cytokines have traditionally been attributed to CD4 T cells, we have found that CD8 T cells are notably abundant in synovium and make ...
A. Jonsson +19 more
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Beyond target cell death - Granzyme serine proteases in health and disease.
Molecular Aspects of Medicine, 2022Granzymes are a family of small (∼32 kDa) serine proteases with a range of substrate specificities that are stored in, and released from, the cytoplasmic secretory vesicles ('granules') of cytotoxic T lymphocytes and natural killer cells.
Simone Nüssing +3 more
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Granzyme B as a therapeutic target: an update in 2022
Expert opinion on therapeutic targets, 2022Introduction Granzyme B is a serine protease extensively studied for its implication in cytotoxic lymphocyte-mediated apoptosis. In recent years, the paradigm that the role of granzyme B is restricted to immune cell-mediated killing has been challenged ...
A. Aubert +3 more
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Biochemistry (Moscow), 2020
Cytotoxic T lymphocytes and natural killer cells eliminate infected cells from the organism by triggering programmed cell death (apoptosis). The contents of the lytic granules of killer cells, including pore-forming proteins perforins and proteolytic enzymes granzymes, are released with the following penetration of the released proteins into the target
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Cytotoxic T lymphocytes and natural killer cells eliminate infected cells from the organism by triggering programmed cell death (apoptosis). The contents of the lytic granules of killer cells, including pore-forming proteins perforins and proteolytic enzymes granzymes, are released with the following penetration of the released proteins into the target
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Granzyme M: behind enemy lines [PDF]
Cell Death and Differentiation, 2014 The granule-exocytosis pathway is the major mechanism via which cytotoxic lymphocytes eliminate virus-infected and tumor cells. In this pathway, cytotoxic lymphocytes release granules containing the pore-forming protein perforin and a family of serine proteases known as granzymes into the immunological synapse.
Niels Bovenschen
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Methods in enzymology, 2008
Granzymes are cell death-inducing serine proteases released from cytotoxic granules of cytotoxic T lymphocytes and natural killer cells during granule exocytosis in response to viral infection or against transformed cells marked for elimination. A critical cofactor for the granule exocytosis pathway is perforin, which mediates the entry of granzymes ...
Martinvalet, Denis +2 more
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Granzymes are cell death-inducing serine proteases released from cytotoxic granules of cytotoxic T lymphocytes and natural killer cells during granule exocytosis in response to viral infection or against transformed cells marked for elimination. A critical cofactor for the granule exocytosis pathway is perforin, which mediates the entry of granzymes ...
Martinvalet, Denis +2 more
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Controversies in granzyme biology
Tissue Antigens, 2012AbstractGranzymes (Grz) are a family of serine proteases found in the granules of cytotoxic lymphocytes and are emerging as an important group of proteins involved in immune function and surveillance. Grz have both cytotoxic and more recently reported non‐cytotoxic roles, however these functions are still subject to thorough investigation.
O, Susanto, J A, Trapani, D, Brasacchio
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