Results 291 to 300 of about 94,825 (337)
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Extracellular granzymes: current perspectives
Biological Chemistry, 2006Granzyme A (GrA) and granzyme B (GrB) play key roles in the induction of target cell death induced by cytotoxic lymphocytes. Whilst these roles have been extensively studied, it is becoming apparent that both granzymes also possess extracellular activities.
Marguerite S, Buzza, Phillip I, Bird
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Immunology Letters, 2019
In addition to expressing inhibitory cytokines and suppressive molecules, Treg cells could downplay inflammation by releasing cytotoxic molecules and eliminating proinflammatory immune cells. Colorectal cancer (CRC) is a common malignancy that has led to
Bing Sun, Mingtao Liu, Meng Cui, Tao Li
semanticscholar +1 more source
In addition to expressing inhibitory cytokines and suppressive molecules, Treg cells could downplay inflammation by releasing cytotoxic molecules and eliminating proinflammatory immune cells. Colorectal cancer (CRC) is a common malignancy that has led to
Bing Sun, Mingtao Liu, Meng Cui, Tao Li
semanticscholar +1 more source
Human neutrophils lack granzyme A, granzyme B, and perforin
Blood, 2004Wagner et al[1][1] and Hochegger et al[2][2] reported that human polymorphonuclear neutrophils (PMNs) express granzyme A (GzmA), granzyme B (GzmB), and perforin (PFN), postulating a role for these granule proteins in PMN-mediated antibody-dependent cellular cytotoxicity.
Sunil S. Metkar, Christopher J. Froelich
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Granzyme B as a therapeutic target for wound healing
Expert opinion on therapeutic targets, 2019Introduction: Granzyme B is a serine protease traditionally understood as having a role in immune-mediated cytotoxicity. Over the past decade, this dogma has been challenged, with a new appreciation that granzyme B can exert alternative extracellular ...
Christopher T. Turner +2 more
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Granzyme B in skin inflammation and disease.
Matrix Biology, 2017Granzyme B (GzmB) is a serine protease emerging as an important mediator of skin injury, inflammation and repair. Found at low levels in healthy skin, GzmB is dramatically elevated in chronic disease and inflammatory skin disorders, including diabetic ...
Christopher T. Turner +2 more
semanticscholar +1 more source
1996
In the last several years the major mechanisms by which both cytotoxic T lymphocytes (CTL) and natural killer (NK) cells mediate cell death and apoptosis have been identified. Cytotoxic lymphocytes of both types induce apoptosis through granule-or Fas-dependent pathway 1-4and perhaps TNF-α5.
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In the last several years the major mechanisms by which both cytotoxic T lymphocytes (CTL) and natural killer (NK) cells mediate cell death and apoptosis have been identified. Cytotoxic lymphocytes of both types induce apoptosis through granule-or Fas-dependent pathway 1-4and perhaps TNF-α5.
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Non‐apoptotic functions of granzymes
Tissue Antigens, 2008AbstractGranzymes (granule enzymes) are proteases released from cytotoxic lymphocyte granules into target cells to protect mammals from virus infection and transformed cells. Once released into the cytoplasm of the target cell, granzymes activate specific pathways to induce cell death. Although the induction of target cell death has been considered the
V, Romero, F, Andrade
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Immunological Reviews, 2010
Summary: Cytotoxic lymphocytes are armed with granules that are released in the granule‐exocytosis pathway to kill tumor cells and virus‐infected cells. Cytotoxic granules contain the pore‐forming protein perforin and a family of structurally homologues serine proteases called granzymes.
Niels, Bovenschen, J Alain, Kummer
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Summary: Cytotoxic lymphocytes are armed with granules that are released in the granule‐exocytosis pathway to kill tumor cells and virus‐infected cells. Cytotoxic granules contain the pore‐forming protein perforin and a family of structurally homologues serine proteases called granzymes.
Niels, Bovenschen, J Alain, Kummer
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Science Signaling, 2000
One key component of the mechanism by which cytotoxic T lymphocytes (CTLs) attack virus-infected or tumor cells is release of cytolytic molecules like the protease granzyme B (grB). Motyka et al. report the discovery that grB uptake is mediated by a receptor--the cation-independent mannose 6-phosphate receptor (CI ...
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One key component of the mechanism by which cytotoxic T lymphocytes (CTLs) attack virus-infected or tumor cells is release of cytolytic molecules like the protease granzyme B (grB). Motyka et al. report the discovery that grB uptake is mediated by a receptor--the cation-independent mannose 6-phosphate receptor (CI ...
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1994
Publisher Summary This chapter highlights purification and assay methods for granzyme B. The highest levels of granzyme B are found in the granules of cytotoxic T lymphocytes (CTLs). Lower levels of granzyme B are found in helper T cells and in thymocytes.
Manuel C. Peitsch, Juerg Tschopp
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Publisher Summary This chapter highlights purification and assay methods for granzyme B. The highest levels of granzyme B are found in the granules of cytotoxic T lymphocytes (CTLs). Lower levels of granzyme B are found in helper T cells and in thymocytes.
Manuel C. Peitsch, Juerg Tschopp
openaire +1 more source