Results 61 to 70 of about 94,825 (337)
NFIL3 contributes to cytotoxic T lymphocyte-mediated killing
Open BiologyCytotoxic T lymphocytes (CTLs) are key effectors of the adaptive immune system that recognize and eliminate virally infected and cancerous cells. In naive CD8+ T cells, T-cell receptor (TCR) engagement drives a number of transcriptional, translational ...
Tiphaine Douanne +5 more
doaj +1 more source
Journal of International Medical Research, 2020 Objectives Little is known about the roles of granzyme B in rheumatoid arthritis (RA). We aimed to evaluate the serum level of granzyme B in patients with RA and determine relationships with clinical features and joint destruction of RA.
Junjie Qiao +7 more
doaj +1 more source
Journal of Cell Science, 2006 Defence against virally infected and malignant cells depends on the action of cytotoxic T lymphocytes and natural killer cells ([Barry and Bleackley, 2002][1]; [Russell and Ley, 2002][2]). Although these use several mechanisms to eliminate target cells, the principal event is secretion of ...
Bots, Michael, Medema, Jan Paul
openaire +3 more sources
Siah2 control of T-regulatory cells limits anti-tumor immunity. [PDF]
, 2020 Understanding the mechanisms underlying anti-tumor immunity is pivotal for improving immune-based cancer therapies. Here, we report that growth of BRAF-mutant melanoma cells is inhibited, up to complete rejection, in Siah2-/- mice.
Aifantis, Ioannis +15 more
core +2 more sources
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
PENGARUH PEMBERIAN ECHINACEA TERHADAP PERBEDAAN EKSPRESI GRANZYME DAN PERKEMBANGAN MASSA TUMOR PADA ADENOKARSINOMA MAMMA MENCIT C3H YANG MENGALAMI STRESS [PDF]
, 2010 Echinacea contains some active compounds which could induce mononuclear cells activiy. Patients with breast carcinoma and stress, the immunity was depress. Echinacea will increase mononuclear cell granzyme expression.
Astanto, Teguh
core
Granzyme B prevents aberrant IL-17 production and intestinal pathogenicity in CD4+ T cells
Mucosal Immunology, 2020 CD4+ T cell activation and differentiation are important events that set the stage for proper immune responses. Many factors are involved in the activation and differentiation of T cells, and these events are tightly controlled to prevent unwanted and/or
K. Hoek +7 more
semanticscholar +1 more source
Granzymes Regulate Proinflammatory Cytokine Responses [PDF]
The Journal of Immunology, 2015 Abstract Granzymes (Grs) are serine proteases mainly produced by cytotoxic lymphocytes and are traditionally considered to cause apoptosis in tumor cells and virally infected cells. However, the cytotoxicity of several Grs is currently being debated, and additional, predominantly extracellular, functions of Grs in inflammation are ...
Wensink, Annette C. +2 more
openaire +3 more sources
Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy
Advanced Functional Materials, EarlyView.FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao +8 more
wiley +1 more source
Egyptian Journal of Chest Disease and Tuberculosis, 2014 Background: Inflammation of the airways is present in COPD with increased number of inflammatory cells including killer cells that lyse their target cells by two mechanisms; membranolysis in which secreted molecules such as granzymes form pores in the ...
Ahmed A. Yousef +4 more
doaj +1 more source