Results 141 to 150 of about 53,159 (257)

Bile acid metabolism and signaling in human and animal health: A One Health perspective

iMetaOmics, EarlyView.
Bile acids maintain host homeostasis through enterohepatic circulation, microbial transformation, and bile acid receptor signaling, thereby regulating glucose and lipid metabolism, intestinal barrier integrity, and immunity. These effects support human disease intervention and health‐oriented animal production, reducing drug dependence and residue ...
Lei Li, Shuai Liu, Zhijun Cao, Yangchun Cao, Shengru Wu, Lu Deng, Junhu Yao, Jun Zhang   +7 more
wiley   +1 more source

Chemotherapy driven alterations in NK cell receptors and ligands in high grade serous ovarian cancer. [PDF]

Front Immunol
Kumar P, Ranmale S, Mehta S, Tongaonkar H, Maniar V, Mania-Pramanik J.   +5 more
europepmc   +1 more source

Single‐cell profiling of peripheral blood reveals acute‐phase immune dysregulation in human scrub typhus

iMeta, EarlyView.
Integrated single‐cell RNA sequencing, spectral flow cytometry, immune‐receptor repertoire profiling, and plasma proteomics revealed coordinated peripheral immune remodeling during acute scrub typhus. Patients exhibited expansion of cytotoxic, clonally amplified CD8+ T cells with exhaustion‐associated features, depletion and apoptosis of CD4+ T cells ...
Yijia Guo, Yi Niu, Nihui Zhang, Xiao Han, Liyuan Zhang, Yongguo Du, Lifen Han, Xiuying Tian, Zhao Xu, Gaoyu Wang, Kwok‐Yung Yuen, Jasper Fuk‐Woo Chan, Dahua Xu, Feifei Yin   +13 more
wiley   +1 more source

Molecular PET and immuno-PET in gastric cancer immunotherapy: current evidence, clinical utilities, and translational barriers. [PDF]

Front Immunol
Hu Q, Sun Y.
europepmc   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Novel insights into the histopathological characteristics of immune checkpoint inhibitor-related myocarditis. [PDF]

ESC Heart Fail
Nishikawa T, Otani T, Yamamoto H, Yasui T, Shingu M, Osumi Y, Ishibashi K, Ikeda Y, Nonaka A, Fukuda Y, Murai R, Furukawa Y, Hara S, Sawaki D, Hiranuma N, Ohashi Y, Takaya T, Asada Y, Ishii N, Kubo T, Kinugasa Y, Date E, Iizuka N, Sakamoto N, Kitai T, Izumi C, Amemiya K, Ohta-Ogo K, Nishihira K, Kinugasa M, Shimokawa T, Tamita K, Fujita M, Hatakeyama K.   +33 more
europepmc   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Correction: Combining lenalidomide with IL-2 family of cytokines enhances activating receptor and perforin/granzyme expression in NK cells. [PDF]

PLoS One
Calescibetta A, Dalton R, Fortenbery N, Ward G, Christiansen S, Chen X, Cheng P, Razabdouski T, Glode AJ, Tu N, Le Trinh T, Liu J, Wright KL, Wei S, Eksioglu EA.   +14 more
europepmc   +1 more source

Black phosphorus‐based photothermal disruption of cancer‐associated fibroblast barriers and tumor‐associated macrophage targeting to enhance anti‐PD‐L1 immunotherapy in triple‐negative breast cancer

Interdisciplinary Medicine, EarlyView.
MBB modulates the TNBC tumor microenvironment by targeting TAM/CXCL1 and facilitates anti‐PD‐L1 therapy by disrupting CAF barriers via its photothermal effect. This combined strategy subsequently enhances the efficacy of PD‐L1 mAb and suppresses TNBC progression, metastasis, and recurrence.
Bo Pan, Shicui Hong, Xinyue Wang, Yanghang Li, Cai Wang, Yaxiao Liu, Ying Chen, Chen Fang, Yifeng Zheng, Shengqi Wang, Juping Zhang, Neng Wang, Zhiyu Wang   +12 more
wiley   +1 more source

Granzyme B PET Imaging Uncovers Dynamic Patterns of Disease Activity and Therapeutic Response in a Murine Colitis Model. [PDF]

Int J Mol Sci
Haj-Mirzaian A, Ma M, Hofmann N, Yuan H, Mahmood U, Heidari P.   +5 more
europepmc   +1 more source