Results 201 to 210 of about 52,710 (257)

Quantification of CD3, FoxP3, and granzyme B immunostaining in canine renal cell carcinoma. [PDF]

Vet Immunol Immunopathol
Cournoyer A, Amerman H, Assenmacher CA, Durham A, Perry JA, Gedney A, Keuler N, Atherton MJ, Lenz JA.   +8 more
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Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization. [PDF]

Angiogenesis
Obasanmi G, Uppal M, Cui JZ, Xi J, Ju MJ, Song J, To E, Li S, Khan W, Cheng D, Zhu J, Irani L, Samad I, Zhu J, Yoo HS, Aubert A, Stoddard J, Neuringer M, Granville DJ, Matsubara JA.   +19 more
europepmc   +1 more source

Reassessing granzyme B: unveiling perforin-independent versatility in immune responses and therapeutic potentials. [PDF]

Front Immunol
Thompson R, Cao X.
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GrB-Fc-KS49, an anti-EMP2 granzyme B fusion protein therapeutic alters immune cell infiltration and suppresses breast cancer growth. [PDF]

J Immunother Cancer
Mohamedali KA, Aguirre B, Lu CH, Chandla A, Kejriwal N, Liu L, Chan AM, Cheung LH, Kok S, Duarte S, Alvarez de Cienfuegos A, Casero D, Rosenblum MG, Wadehra M.   +13 more
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Granzyme B in injury, inflammation, and repair

Trends in Molecular Medicine, 2012
Fragile skin and susceptibility to skin tearing are major problems among the elderly and can be complicated further by impaired wound healing. Non-healing wounds fail to progress through the normal stages of healing and enter a state of chronic inflammation featuring increased proteolytic activity. Increased expression of the serine protease granzyme B
David Granville
exaly   +3 more sources

Apoptosis induced by granzyme B

Russian Journal of Bioorganic Chemistry, 2008
Results of biochemical studies of apoptosis reactions induced by granzyme B are considered and summarized. Special attention is paid to the reactions of procaspase activation and limited proteolysis of apoptotic targets. Found values of kinetic constants of granzyme B-mediated enzymatic reactions are listed.
A V, Sintsov, E I, Kovalenko, M A, Khanin   +2 more
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Granzyme B: a natural born killer

Immunological Reviews, 2003
Summary:  A main pathway used by cytotoxic T lymphocytes (CTLs) and natural killer cells to eliminate pathogenic cells is via exocytosis of granule components in the direction of the target cell, delivering a lethal hit of cytolytic molecules. Amongst these, granzyme B and perforin have been shown to induce CTL‐mediated target cell DNA fragmentation ...
Sarah J, Lord, Ray V, Rajotte, Gregory S, Korbutt, R Chris, Bleackley   +3 more
openaire   +2 more sources