Results 211 to 220 of about 52,710 (257)
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Science Signaling, 2000
One key component of the mechanism by which cytotoxic T lymphocytes (CTLs) attack virus-infected or tumor cells is release of cytolytic molecules like the protease granzyme B (grB). Motyka et al. report the discovery that grB uptake is mediated by a receptor--the cation-independent mannose 6-phosphate receptor (CI ...
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One key component of the mechanism by which cytotoxic T lymphocytes (CTLs) attack virus-infected or tumor cells is release of cytolytic molecules like the protease granzyme B (grB). Motyka et al. report the discovery that grB uptake is mediated by a receptor--the cation-independent mannose 6-phosphate receptor (CI ...
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Purification and Use of Granzyme B
2000Granzyme B (GrB) is the primary molecular mediator of apoptosis by cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. It is a unique mammalian aspartic acid-cleaving serine protease. On T cell receptor activation, GrB is released from the CTL cytoplasmic granules by exocytosis, enters the target cells and, in the presence of the granule pore-
L, Shi +3 more
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Human neutrophils lack granzyme A, granzyme B, and perforin
Blood, 2004Wagner et al[1][1] and Hochegger et al[2][2] reported that human polymorphonuclear neutrophils (PMNs) express granzyme A (GzmA), granzyme B (GzmB), and perforin (PFN), postulating a role for these granule proteins in PMN-mediated antibody-dependent cellular cytotoxicity.
Sunil S. Metkar, Christopher J. Froelich
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1994
Publisher Summary This chapter highlights purification and assay methods for granzyme B. The highest levels of granzyme B are found in the granules of cytotoxic T lymphocytes (CTLs). Lower levels of granzyme B are found in helper T cells and in thymocytes.
Manuel C. Peitsch, Juerg Tschopp
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Publisher Summary This chapter highlights purification and assay methods for granzyme B. The highest levels of granzyme B are found in the granules of cytotoxic T lymphocytes (CTLs). Lower levels of granzyme B are found in helper T cells and in thymocytes.
Manuel C. Peitsch, Juerg Tschopp
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Granzyme B in skin inflammation and disease
Matrix Biology, 2019Granzyme B (GzmB) is a serine protease emerging as an important mediator of skin injury, inflammation and repair. Found at low levels in healthy skin, GzmB is dramatically elevated in chronic disease and inflammatory skin disorders, including diabetic ulcers, hypertrophic scarring, autoimmune skin disorders, cutaneous leishmaniasis and aging skin ...
Christopher T, Turner +2 more
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Identification and characterization of equine granzyme B
Veterinary Immunology and Immunopathology, 2007In the present study we describe the isolation and characterization of putative equine granzyme B for which we propose the designation 'eqGrzmB'. Sequence analysis revealed characteristic features of a GrzmB protease such as the presence of a signal (leader-) peptide and an activation di-peptide.
Konrad, Piuko +2 more
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Acta Haematologica, 2003
Granzyme B (GrB) is a serine protease that is released by cytotoxic lymphocytes to kill virus-infected and tumor cells. Recent advances in the understanding of GrB have stressed the importance of reassessing the mechanisms by which GrB accomplishes its death functions.
Felipe, Andrade +2 more
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Granzyme B (GrB) is a serine protease that is released by cytotoxic lymphocytes to kill virus-infected and tumor cells. Recent advances in the understanding of GrB have stressed the importance of reassessing the mechanisms by which GrB accomplishes its death functions.
Felipe, Andrade +2 more
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1996
In the last several years the major mechanisms by which both cytotoxic T lymphocytes (CTL) and natural killer (NK) cells mediate cell death and apoptosis have been identified. Cytotoxic lymphocytes of both types induce apoptosis through granule-or Fas-dependent pathway 1-4and perhaps TNF-α5.
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In the last several years the major mechanisms by which both cytotoxic T lymphocytes (CTL) and natural killer (NK) cells mediate cell death and apoptosis have been identified. Cytotoxic lymphocytes of both types induce apoptosis through granule-or Fas-dependent pathway 1-4and perhaps TNF-α5.
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Entry and Trafficking of Granzyme B in Target Cells During Granzyme B-Perforin–Mediated Apoptosis
Blood, 1998AbstractIn the widely accepted model of granule-mediated killing by cytotoxic lymphocytes, granzyme B entry into the target cell is facilitated by the pore forming molecule, perforin. Using indirect immunofluorescence and also direct visualization of fluorescein isothiocyanate (FITC)-conjugated granzyme B, we demonstrate internalization in the absence ...
M J, Pinkoski +7 more
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Delivery and therapeutic potential of human granzyme B
Immunological Reviews, 2010Summary: Granzyme B (GzmB) is used by cytotoxic lymphocytes as a molecular weapon for the defense against virus‐infected and malignantly transformed host cells. It belongs to a family of small serine proteases that are stored in secretory vesicles of killer cells.
Kurschus, F., Jenne, D.
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