Results 31 to 40 of about 78,129 (305)

The TreaT-Assay: A Novel Urine-Derived Donor Kidney Cell-Based Assay for Prediction of Kidney Transplantation Outcome [PDF]

, 2019
Donor-reactive immunity plays a major role in rejection after kidney transplantation, but analysis of donor-reactive T-cells is not applied routinely. However, it has been shown that this could help to identify patients at risk of acute rejection.
Babel, Nina, Choi, Mira, Kurtz, Andreas, Lachmann, Nils, Mueskes, Annemarie, Nickel, Peter, Reinke, Petra, Roch, Toralf, Rosiewicz, Kamil, Schmueck-Henneresse, Michael, Stein, Maik, Stervbo, Ulrik, Thieme, Constantin J., Wehler, Patrizia, Weist, Benjamin J. D., Westhoff, Timm H.   +15 more
core   +1 more source

Induction of granzyme B expression in T-cell receptor/CD28-stimulated human regulatory T cells is suppressed by inhibitors of the PI3K-mTOR pathway

BMC Immunology, 2009
Background Regulatory T cells (Tregs) can employ a cell contact- and granzyme B-dependent mechanism to mediate suppression of bystander T and B cells.
Kelley Todd W, Efimova Olga V
doaj   +1 more source

Granzyme B inhibition reduces disease severity in autoimmune blistering diseases

Nature Communications, 2021
Pemphigoid diseases involve autoimmune mediated blistering and immunopathology of the upper dermis. Here, the authors implicate granzyme B in the immunopathology in multiple in vivo models of pemphigoid diseases and utilise a topical granzyme B inhibitor
Sho Hiroyasu, Matthew R. Zeglinski, Hongyan Zhao, Megan A. Pawluk, Christopher T. Turner, Anika Kasprick, Chiharu Tateishi, Wataru Nishie, Angela Burleigh, Peter A. Lennox, Nancy Van Laeken, Nick J. Carr, Frank Petersen, Richard I. Crawford, Hiroshi Shimizu, Daisuke Tsuruta, Ralf J. Ludwig, David J. Granville   +17 more
doaj   +1 more source

Discordant Regulation of Granzyme H and Granzyme B Expression in Human Lymphocytes [PDF]

Journal of Biological Chemistry, 2004
We analyzed the expression of granzyme H in human blood leukocytes, using a novel monoclonal antibody raised against recombinant granzyme H. 33-kDa granzyme H was easily detected in unfractionated peripheral blood mononuclear cells, due to its high constitutive expression in CD3(-)CD56(+) natural killer (NK) cells, whereas granzyme B was less abundant.
Karin A, Sedelies, Thomas J, Sayers, Kirsten M, Edwards, Weisan, Chen, Daniel G, Pellicci, Dale I, Godfrey, Joseph A, Trapani   +6 more
openaire   +2 more sources

Expression of intra- and extracellular granzymes in patients with typhoid fever.

PLoS Neglected Tropical Diseases, 2017
BackgroundTyphoid fever, caused by the intracellular pathogen Salmonella (S.) enterica serovar Typhi, remains a major cause of morbidity and mortality worldwide.
Hanna K de Jong, Maria Isabel Garcia-Laorden, Arie J Hoogendijk, Christopher M Parry, Rapeephan R Maude, Arjen M Dondorp, Mohammed Abul Faiz, Tom van der Poll, Willem Joost Wiersinga   +8 more
doaj   +1 more source

A fluorogenic probe for granzyme B enables in-biopsy evaluation and screening of response to anticancer immunotherapies

Nature Communications, 2022
Granzyme B is found in activated T cells and can be used as a marker of T cell activation. Here, the authors generate a fluorescent probe that can detect Granzyme B levels in tumours, and has the potential to be used as a biomarker of response to ...
Jamie I. Scott, Lorena Mendive-Tapia, Doireann Gordon, Nicole D. Barth, Emily J. Thompson, Zhiming Cheng, David Taggart, Takanori Kitamura, Alberto Bravo-Blas, Edward W. Roberts, Jordi Juarez-Jimenez, Julien Michel, Berber Piet, I. Jolanda de Vries, Martijn Verdoes, John Dawson, Neil O. Carragher, Richard A. O’ Connor, Ahsan R. Akram, Margaret Frame, Alan Serrels, Marc Vendrell   +21 more
doaj   +1 more source

Granzyme B cleavage of autoantigens in autoimmunity [PDF]

Cell Death & Differentiation, 2010
The systemic autoimmune diseases are a complex group of disorders characterized by elaboration of high titer autoantibodies and immune-mediated damage of tissues. Two striking features of autoimmune rheumatic diseases are their self-sustaining nature and capacity for autoamplification, exemplified by disease flares.
E, Darrah, A, Rosen
openaire   +2 more sources

Mechanisms Responsible for Granzyme B–Independent Cytotoxicity [PDF]

Blood, 1997
AbstractUsing granzyme B–deficient mice obtained by gene targeting, we previously demonstrated that granzyme B is required for the rapid induction of apoptotic target cell death by cytotoxic T lymphocytes (CTLs); however, CTLs are also equipped with additional effector mechanisms.
S, Shresta, J H, Russell, T J, Ley
openaire   +2 more sources

The intestinal expulsion of the roundworm Ascaris suum is associated with eosinophils, intra-epithelial T cells and decreased intestinal transit time [PDF]

, 2013
Ascaris lumbricoides remains the most common endoparasite in humans, yet there is still very little information available about the immunological principles of protection, especially those directed against larval stages.
A Fujiwara, A Roepstorff, A Zhao, A Zhao, Aaron R. Jex, BA Vallance, C Dold, C Moolenbeek, C Zhou, CD Criscione, CV Holland, D Leles, D Masure, Dries Masure, DW Crompton, F van Wijk, G Jungersen, GH Liu, HD Dawson, J Vandesompele, JF Urban Jr, Jimmy Saunders, Johnny Vlaminck, Jozef Vercruysse, KD Mccoy, Koen Chiers, L Eriksen, M Ashraf, M Morimoto, N Arizono, N Foster, N Miquel, NL Harris, P Kermanizadeh, P Nejsum, P O'Lorcain, PA Knight, Peter Geldhof, PI Uston, R Shamri, RM Anthony, RW Li, S Rozen, S Schmidt, Sarah Claerhoudt, Tao Wang, TB Stewart, TJ Anderson, Wim Van den Broeck   +48 more
core   +4 more sources

Protease-activated receptor-1 activation by granzyme B causes neurotoxicity that is augmented by interleukin-1β

Journal of Neuroinflammation, 2017
Background The cause of neurodegeneration in progressive forms of multiple sclerosis is unknown. We investigated the impact of specific neuroinflammatory markers on human neurons to identify potential therapeutic targets for neuroprotection against ...
Paul R. Lee, Tory P. Johnson, Sharmilee Gnanapavan, Gavin Giovannoni, Tongguang Wang, Joseph P. Steiner, Marie Medynets, Mark J. Vaal, Valerie Gartner, Avindra Nath   +9 more
doaj   +1 more source