Results 41 to 50 of about 78,129 (305)

Granule Leakage Induces Cell-Intrinsic, Granzyme B-Mediated Apoptosis in Mast Cells

Frontiers in Cell and Developmental Biology, 2021
Mast cells are multifunctional immune cells scattered in tissues near blood vessels and mucosal surfaces where they mediate important reactions against parasites and contribute to the pathogenesis of allergic reactions.
Sabrina Sofia Burgener, Sabrina Sofia Burgener, Melanie Brügger, Melanie Brügger, Melanie Brügger, Nathan Georges François Leborgne, Nathan Georges François Leborgne, Sophia Sollberger, Sophia Sollberger, Paola Basilico, Paola Basilico, Thomas Kaufmann, Phillip Ian Bird, Charaf Benarafa, Charaf Benarafa   +14 more
doaj   +1 more source

Human plasma cells express granzyme B [PDF]

European Journal of Immunology, 2013
While studying the plasma cell (PC) compartment in human tonsils, we identified that immunoglobulin kappa or lambda chain‐expressing PCs are the main cells expressing granzyme B (GrzB). In vitro studies revealed that activated B cells differentiated into GrzB‐expressing PCs when co‐cultured with macrophages and follicular helper T cells.
Xu, Wei, Narayanan, Priya, Kang, Ning, Clayton, Sandra, Ohne, Yoichiro, Shi, Peiqing, Herve, Marie-Cecile, Balderas, Robert, Picard, Capucine, Casanova, Jean-Laurent, Gorvel, Jean-Pierre, Oh, Sangkon, Pascual, Virginia, Banchereau, Jacques   +13 more
openaire   +2 more sources

Natural killer cells in placentation and cancer: Implications for hypertension during pregnancy [PDF]

, 2017
Hypertension during pregnancy is the most common medical condition encountered during gestation. Despite this, knowledge of the mechanisms that underlie the disease and the development of new therapies are limited.
Cornelius, Denise C., Delles, Christian, Guzik, Tomasz J., Small, Heather Yvonne   +3 more
core   +1 more source

Overrepresentation of IL-10-Expressing B Cells Suppresses Cytotoxic CD4+ T Cell Activity in HBV-Induced Hepatocellular Carcinoma. [PDF]

PLoS ONE, 2016
Hepatocellular carcinoma (HCC) is a common cancer with poor prognosis and low five-year survival rate. A strong and effective CD4+ T cell-mediated cytotoxicity was associated with better survival and low recurrence rate in HCC, but the regulatory ...
Hongwei Xue, Fuhuang Lin, Hongwu Tan, Zun-Qiang Zhu, Zhang-Yun Zhang, Ludong Zhao   +5 more
doaj   +1 more source

TREX1 DNA exonuclease deficiency, accumulation of single stranded DNA and complex human genetic disorders [PDF]

, 2008
Aicardi-Goutieres syndrome (AGS) is an unusual condition that clinically mimics a congenital viral infection. Several genes have recently been implicated in the aetiology of this disorder. One of these genes encodes the DNA exonuclease TREX1. Recent work
Aicardi, Akira, Alderton, Alderton, Bartek, Bartkova, Brennan, Brucet, Chen, Chowdhury, Crow, Crow, de Silva, DiTullio, Driscoll, Gasser, Griffith, Griffiths, Höss, Jazayeri, Kawai, Lee-Kirsch, Lee-Kirsch, Lieberman, Lieberman, Lindahl, Lindahl, Liu, Liu, Liu, Mark O’Driscoll, Martinvalet, Mazur, Mazur, Morita, Napirei, O’Driscoll, O’Driscoll, Qiu, Raulet, Rhodes, Rice, Richards, Shevelev, Stiff, Stiff, Takaoka, Tran, Tsukumo, Vyse, Walport, Yang, Yasutomo, Zou, Zou   +54 more
core   +1 more source

Imaging Granzyme B Activity Assesses Immune-Mediated Myocarditis [PDF]

Circulation Research, 2015
Rationale: The development of molecular imaging approaches that assess specific immunopathologic mechanisms can advance the study of myocarditis. Objective: This study validates a novel molecular imaging tool ...
Konishi, Masanori, Erdem, Sultan Sibel, Weissleder, Ralph, Lichtman, Andrew, McCarthy, Jason, Libby, Peter   +5 more
openaire   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Granzyme B; the chalk-mark of a cytotoxic lymphocyte

Journal of Translational Medicine, 2004
During cytotoxic lymphocyte (CL) mediated killing of target cells, granzyme B is released from the CL into the immune synapse. Recent studies have found that ELISPOT-detection of granzyme B correlated well with conventional assays for CL mediated killing.
Clarke Chris JP, Sedelies Karin A, Waterhouse Nigel J   +2 more
doaj   +1 more source

Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy

Advanced Functional Materials, EarlyView.
FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao, Yejing Zhu, Hengchao Yu, Jun Zhu, Bo Wang, Yu Qiao, Zhimin Tian, Junlong Zhao, Lei Liu   +8 more
wiley   +1 more source

Structure and evolutionary origin of the human granzyme H gene [PDF]

, 2017
Among the molecules proposed to be involved In cytotoxic T lymphocyte (CTL), natural killer (NK) and lymphokine activated killer (LAK) cell-mediated lysis are the granzymes, a family of serine proteases stored in the cytoplasmic granules of CTLs, NK and ...
Clément, Marie-Véronique, Haddad, Patrick, Jenne, Dieter, Mathieu-Mahul, Danièle, Sasportes, Marilyne, Tschopp, Jürg   +5 more
core