Integrated Engineering of CAR‐T Cells for Solid Tumours
Cell Proliferation, EarlyView.Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang +5 more
wiley +1 more source
Development of Granzyme A Turn-ON Fluorescent Activity-Based Probes. [PDF]
ChembiochemMalespini SM, Kazim M, Yoo E.
europepmc +1 more source
Immunopathogenesis, Diagnosis, and Treatment of Hashimoto's Thyroiditis. [PDF]
Arch Intern Med ResDelgadillo F, Agrawal DK.
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Curcumin as a Dual Modulator of Pyroptosis: Mechanistic Insights and Therapeutic Potential. [PDF]
Int J Mol SciMoon DO.
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Beyond interferon gamma - decreased cellular response to COVID-19 vaccination booster in patients with autoimmune inflammatory rheumatic diseases. [PDF]
Front ImmunolWroński J +9 more
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Dual Roles of MAIT Cells in the Tumor Microenvironment: Implications for Cancer Immunity and Therapy. [PDF]
Immune NetwChoi J, Lee YJ.
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Hemophagocytic lymphohistiocytosis caused by dual mutations in UNC13D and STX11 induced by HHV-7: a case report and review of the literature. [PDF]
Ann HematolWang X +7 more
europepmc +1 more source
Granzymes in cancer and immunity [PDF]
Cell Death and Differentiation, 2010 Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells are indispensable factors in the body's ongoing defence against viral infection and tumor development. CTL/NK cells recognize and kill infected or aberrant target cells by two major pathways: either through introduction of a battery of proteases - called granzymes - to the target cell cytosol,
Seamus Martin, Martin S J
exaly +3 more sources
A quarter century of granzymes [PDF]
Cell Death and Differentiation, 2011 Granzymes (Grs) were discovered just over a quarter century ago. They are produced by cytotoxic T cells and natural killer cells and are released upon interaction with target cells. Intensive biochemical, genetic, and biological studies have been performed in order to study their roles in immunity and inflammation.
Bleackley R C, Kane K P, R C Bleackley
exaly +3 more sources
Granzymes—Their Role in Colorectal Cancer
International Journal of Molecular Sciences, 2022 Colorectal cancer (CRC) is among the most common malignancies worldwide. CRC is considered a heterogeneous disease due to various clinical symptoms, biological behaviours, and a variety of mutations. A number of studies demonstrate that as many as 50% of CRC patients have distant metastases at the time of diagnosis.
Marta Łukaszewicz-Zając +2 more
exaly +3 more sources