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Biochemistry (Moscow), 2020
Cytotoxic T lymphocytes and natural killer cells eliminate infected cells from the organism by triggering programmed cell death (apoptosis). The contents of the lytic granules of killer cells, including pore-forming proteins perforins and proteolytic enzymes granzymes, are released with the following penetration of the released proteins into the target
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Cytotoxic T lymphocytes and natural killer cells eliminate infected cells from the organism by triggering programmed cell death (apoptosis). The contents of the lytic granules of killer cells, including pore-forming proteins perforins and proteolytic enzymes granzymes, are released with the following penetration of the released proteins into the target
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Methods in enzymology, 2008
Granzymes are cell death-inducing serine proteases released from cytotoxic granules of cytotoxic T lymphocytes and natural killer cells during granule exocytosis in response to viral infection or against transformed cells marked for elimination. A critical cofactor for the granule exocytosis pathway is perforin, which mediates the entry of granzymes ...
Martinvalet, Denis +2 more
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Granzymes are cell death-inducing serine proteases released from cytotoxic granules of cytotoxic T lymphocytes and natural killer cells during granule exocytosis in response to viral infection or against transformed cells marked for elimination. A critical cofactor for the granule exocytosis pathway is perforin, which mediates the entry of granzymes ...
Martinvalet, Denis +2 more
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Granzyme A is a proinflammatory protease
Blood, 2009To the editor: We have read with great interest the paper by Zhu et al[1][1] that suggests poly ADP ribose polymerase 1 (PARP-1) is cleaved when granzyme A (gzmA) enters target cells. This new finding may have implications for the proinflammatory effects of this protease.[2][2][⇓][3]–[4][4]
Julián, Pardo +2 more
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Controversies in granzyme biology
Tissue Antigens, 2012AbstractGranzymes (Grz) are a family of serine proteases found in the granules of cytotoxic lymphocytes and are emerging as an important group of proteins involved in immune function and surveillance. Grz have both cytotoxic and more recently reported non‐cytotoxic roles, however these functions are still subject to thorough investigation.
O, Susanto, J A, Trapani, D, Brasacchio
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Human neutrophils lack granzyme A, granzyme B, and perforin
Blood, 2004Wagner et al[1][1] and Hochegger et al[2][2] reported that human polymorphonuclear neutrophils (PMNs) express granzyme A (GzmA), granzyme B (GzmB), and perforin (PFN), postulating a role for these granule proteins in PMN-mediated antibody-dependent cellular cytotoxicity.
Sunil S. Metkar, Christopher J. Froelich
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1994
Publisher Summary Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells of human, mouse, and rat origin express a large number of homologous serine proteinases. These proteinases are termed “granzymes,” as they are stored within cytoplasmic granules.
Markus M. Simon, Michael D. Kramer
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Publisher Summary Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells of human, mouse, and rat origin express a large number of homologous serine proteinases. These proteinases are termed “granzymes,” as they are stored within cytoplasmic granules.
Markus M. Simon, Michael D. Kramer
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1996
In the last several years the major mechanisms by which both cytotoxic T lymphocytes (CTL) and natural killer (NK) cells mediate cell death and apoptosis have been identified. Cytotoxic lymphocytes of both types induce apoptosis through granule-or Fas-dependent pathway 1-4and perhaps TNF-α5.
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In the last several years the major mechanisms by which both cytotoxic T lymphocytes (CTL) and natural killer (NK) cells mediate cell death and apoptosis have been identified. Cytotoxic lymphocytes of both types induce apoptosis through granule-or Fas-dependent pathway 1-4and perhaps TNF-α5.
openaire +2 more sources