Results 81 to 90 of about 117,917 (289)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

The importance of graph databases and graph learning for clinical applications. [PDF]

open access: yesDatabase (Oxford), 2023
Walke D   +6 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

Concurrent Access Performance Comparison Between Relational Databases and Graph NoSQL Databases for Complex Algorithms

open access: yesApplied Sciences
Databases are a fundamental element of contemporary software applications. The most widely used and recognized type in practice is the relational database, valued for its ability to store and organize data in tabular structures, its emphasis on data ...
Elena Lupu   +2 more
doaj   +1 more source

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa   +10 more
wiley   +1 more source

An overview of graph databases and their applications in the biomedical domain. [PDF]

open access: yesDatabase (Oxford), 2021
Timón-Reina S   +2 more
europepmc   +1 more source

Survey: Graph Databases

open access: yes
Graph databases have become essential tools for managing complex and interconnected data, which is common in areas like social networks, bioinformatics, and recommendation systems. Unlike traditional relational databases, graph databases offer a more natural way to model and query intricate relationships, making them particularly effective for ...
Coimbra, Miguel E.   +3 more
openaire   +2 more sources

Whole‐Body Pattern of Muscle Degeneration and Progression in Sarcoglycanopathies

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize whole‐body intramuscular fat distribution pattern in patients with sarcoglycanopathies and explore correlations with disease severity, duration and age at onset. Methods Retrospective, cross‐sectional, multicentric study enrolling patients with variants in one of the four sarcoglycan genes who underwent whole‐body ...
Laura Costa‐Comellas   +39 more
wiley   +1 more source

Reshaping Smart Businesses with Cloud Database Solutions [PDF]

open access: yesDatabase Systems Journal, 2015
The aim of this article is to show the importance of Big Data and its growing influence on companies. We can also see how much are the companies willing to invest in big data and how much are they currently gaining from their big data.
Bogdan NEDELCU   +3 more
doaj  

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