Results 61 to 70 of about 4,672,404 (295)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
DIE GRAPHIC NOVEL IM FREMDSPRACHENUNTERRICHT
Studia Universitatis Babeş-Bolyai. Philologia, 2017 Graphic Novel in Foreign Language Class. Working with graphic novels in a foreign language class increases the motivation of learners towards the language.
Jeannine FEIX
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Using digital storytelling as a methodology for the introduction of socially responsible graphic design in a University Bachelor of Computer Graphic Design Programme [PDF]
, 2009 This paper case studies the pedagogical methodology for a digital storytelling project involving final semester Bachelor of Computer Graphic Design students and students from a community based charitable arts trust. A young artist is paired with a senior
Vanderschantz, Nicholas
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Grey Skin, Grey Water: Iterations of Bhartrhari’s Sphota in Amruta Patil’s Kari
ILN Journal: Indian Literary NarrativesThis article examines Bhartrhari’s concept of sphota as a critical framework for interpreting the intermedial dynamics of text and image in contemporary graphic narratives, with specific reference to Amruta Patil’s Kari.
Uma Madhu, Prof. Amith Kumar P.V
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, 2018 Στο πλαίσιο της Σύγχρονης Παιδαγωγικής και της Παιδαγωγικής των Πολυγραμματισμών, βασικός στόχος του σύγχρονου σχολείου είναι η καλλιέργεια του κριτικού γραμματισμού των μαθητών/μαθητριών με την αξιοποίηση πολυτροπικών κειμένων, όπως τα graphic novels ...
Ρωμανού, Αικατερίνη
core
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
, 2020 The article deals with the graphic novel “The Cossacks: A novel about the life of the Don Cossacks” by S. Soloviev published in Belgrade in 1938–1939.
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source