Results 161 to 170 of about 9,076 (199)

Identification of a potential transcriptional regulator encoded by grass carp reovirus

Archives of Virology, 2019
Many transcription factors are encoded by DNA viruses and retroviruses due to their regulatory roles in gene expression in the host cell. However, no transcriptional regulator has been identified in any reovirus. Here, a non-structural protein, NS31, encoded by grass carp reovirus genomic segment S7 was characterized.
Fei, Yu, Hao, Wang, Longlong, Wang, Wanjuan, Li, Liqun, Lu   +4 more
openaire   +2 more sources

Grass carp reovirus VP6 inhibits IFN production by degrading TBK1 through the autophagy pathway.

Fish and Shellfish Immunology
The interferon (IFN) response serves as a powerful defense mechanism against viral infections in fish. However, grass carp reovirus (GCRV) is capable of evading the IFN system, although the specific mechanisms remain unclear.
Xiao Xu, Zhuo-Cong Li, Bao-jie Cui, Can Zhang, Na Xu, Yang-Yang Wang, Dan-Dan Chen, Long-Feng Lu, Shun Li   +8 more
semanticscholar   +1 more source

Grass carp superoxide dismutases exert antioxidant function and inhibit autophagy to promote grass carp reovirus (GCRV) replication.

International Journal of Biological Macromolecules, 2023
Superoxide dismutases (SODs) are potent antioxidants crucial for neutralizing reactive oxygen species (ROS) and protecting organisms from oxidative damage.
Xinyu Liang, Qian Wang, Hanyue Wang, Xuyang Wang, Pengfei Chu, Cheng Yang, Yongming Li, L. Liao, Zuo-Yani Zhu, Yaping Wang, Libo He   +10 more
semanticscholar   +1 more source

3D reconstruction and capsid protein characterization of grass carp reovirus

Science in China Series C, 2005
Grass carp reovirus (GCRV) is a relatively new virus first isolated in China and is a member of the Aquareovirus genus of the Reoviridae family. Recent report of genomic sequencing showed that GCRV shared high degree of homology with mammalian reovirus (MRV). As a step of our effort to understand the structural basis of GCRV pathogenesis, we determined
Qin, Fang, Sanket, Shah, Yuyao, Liang, Z H, Zhou   +3 more
openaire   +2 more sources

Recombinant surface display vaccine enhances the immersion immune effect against grass carp reovirus in grass carp (Ctenopharyngodon idella).

Fish and Shellfish Immunology, 2023
Grass carp (Ctenopharyngodon idella) is subject to a hemorrhagic disease caused by grass carp reovirus (GCRV), which can lead to mass mortality in grass carp culture, causing significant economic loss.
K. Hao, Yu Wang, Bin Zhu, Fei Yu, Zhe Zhao, Gaoxue Wang   +5 more
semanticscholar   +1 more source

Liver X Receptor LXRα Promotes Grass Carp Reovirus Infection by Attenuating IRF3-CBP Interaction and Inhibiting RLR Antiviral Signaling.

Journal of Immunology, 2023
Liver X receptors (LXRs) are nuclear receptors involved in metabolism and the immune response. Different from mammalian LXRs, which include two isoforms, LXRα and LXRβ, only a single LXRα gene exists in the piscine genomes. Although a study has suggested
Yun Jie Song, Jie Zhang, Zhen Xu, P. Nie, M. Chang   +4 more
semanticscholar   +1 more source

Cd36 deficiency enhances the immune defence against Grass Carp Reovirus in zebrafish.

Developmental and Comparative Immunology
CD36, a single-chain transmembrane glycoprotein belonging to the class B scavenger receptor family, remains enigmatic in terms of its antiviral immune function, with some conflicting conclusions. This study aims to elucidate the role of Cd36 in antiviral
Jing Gao, Wenjin Li, Meng Li, Guangdong Ji, Zhenhui Liu   +4 more
semanticscholar   +1 more source

Comparative transcriptional analysis between virulent isolate HN1307 and avirulent isolate GD1108 of grass carp reovirus genotype II.

Developmental and Comparative Immunology, 2023
As a widespread epidemic virus, genotype II of the grass carp reovirus poses a significant threat to the grass carp farming industry in China. Different genotype II isolates cause different degrees of virulence, although the underlying pathogenic ...
Yingying Wang, Shucheng Zheng, Weiwei Zeng, Jiyuan Yin, Yingying Li, Yan Ren, Xubing Mo, C. Shi, S. Bergmann, Qing Wang   +9 more
semanticscholar   +1 more source

Reticulon 4a Facilitates Grass Carp Reovirus Replication by Integrating Membrane Remodeling and Viral Protein Recruitment via Its Reticulon Homology Domain.

Fish and Shellfish Immunology
Grass Carp Reovirus (GCRV)-induced hemorrhagic disease imposes substantial economic losses in aquaculture, yet the molecular mechanisms by which it hijacks host factors to construct viral inclusion bodies (VIBs) remain poorly understood.
Yunjie Song, Yang Chen, An Li, Y. Yue, Xinyu Jiang, Xudong Li, Hehe Xiao, Yanjing Zhao, Chao Pei, Xianghui Kong   +9 more
semanticscholar   +1 more source

Metabolomics in rare minnow (Gobiocypris rarus) after infection by attenuated and virulent grass carp reovirus genotype Ⅱ.

Fish and Shellfish Immunology, 2023
Grass carp reovirus genotype Ⅱ (GCRV Ⅱ) causes hemorrhagic disease in a variety fish, seriously affecting the aquaculture industry in China. However, the pathogenesis of GCRV Ⅱ is unclear.
Jie Ma, Chen Xu, Yongze Zhou, Nan Jiang, Mingyang Xue, Jiajia Cao, Shuang Li, Yuding Fan   +7 more
semanticscholar   +1 more source