Results 1 to 10 of about 954 (183)

GCRV-II Triggers B and T Lymphocyte Apoptosis via Mitochondrial ROS Pathway [PDF]

Viruses
Grass carp reovirus (GCRV), particularly the highly prevalent genotype II (GCRV-II), is known to infect peripheral blood leukocytes (PBLs) of grass carp. However, it is unclear whether GCRV-II can induce apoptosis in bystander lymphocytes within infected
Yong-An Zhang, Xu-Jie Zhang, Chang-Song Wu   +2 more
exaly   +7 more sources

GCRV 096 VP6 protein and its impacts on GCRV replication with different genotypes in CIK cells

Aquaculture and Fisheries, 2018
Grass carp reovirus (GCRV) is the causative agent of grass carp hemorrhagic disease, which has detrimental effects on the grass carp aquaculture industry. There are four known genotypes of GCRV and strains of different GCRV genotypes differ greatly.
Jichang Jian, Zaohe Wu
exaly   +5 more sources

Recombinant Baculovirus-Produced Grass Carp Reovirus Virus-Like Particles as Vaccine Candidate That Provides Protective Immunity against GCRV Genotype II Infection in Grass Carp [PDF]

Vaccines, 2021
Grass carp reovirus (GCRV) leads to severe hemorrhagic disease in grass carp (Ctenopharyngodon idella) and causes economic losses in grass carp aquaculture.
Jiyuan Yin, Qing Wang, Yingying Li
exaly   +4 more sources

First Investigation of Grass Carp Reovirus (GCRV) Infection in Amphioxus: Insights into Pathological Effects, Transmission, and Transcriptomic Responses [PDF]

Viruses
Amphioxus belongs to the subphylum Cephalochordata and occupies a transitional position in evolution between invertebrates and vertebrates. Due to the lack of viruses suitable for immunostimulation in amphioxus, this study for the first time explored the
Jingyuan Lin, Meng Yang, Huijuan Yang, Guangdong Ji, Zhenhui Liu   +4 more
doaj   +3 more sources

Type II grass carp reovirus utilizes autophagosomes for viroplasm formation and subclinical persistent infection [PDF]

Journal of Virology
Grass carp reovirus (GCRV) is the most virulent pathogen within the genus Aquareovirus, belonging to the family Spinareoviridae. GCRV is categorized into three genotypes, with type II (GCRV-II) being the predominant strain circulating in China ...
Qian Wang, Zichao Peng, Pengfei Chu, Bin Gui, Yongming Li, Lanjie Liao, Zuoyan Zhu, Fei Ke, Yaping Wang, Libo He   +9 more
doaj   +2 more sources

Cell surface heparan sulfate is an attachment receptor for grass carp reovirus [PDF]

iScience
Summary: Grass carp reovirus (GCRV) causes hemorrhagic disease in grass carp, leading to significant economic losses in China’s aquaculture. However, the cellular receptors responsible for the initiation of GCRV infection remain unclear.
Qian Wang, Hanyue Wang, Xuyang Wang, Cheng Yang, Yongming Li, Lanjie Liao, Zuoyan Zhu, Yaping Wang, Libo He   +8 more
doaj   +2 more sources

Grass carp reovirus VP35 hijacks DHX15 into phase-separated inclusion bodies to evade host antiviral immunity [PDF]

Cell Communication and Signaling
Many viral proteins undergo liquid-liquid phase separation (LLPS) to form biomolecular condensates known as viral inclusion bodies (VIBs), which are utilized for genome replication and virion assembly, thus serving as potential targets for antiviral ...
Chu Zhang, Zhen Lv, Weiwei Zeng, Yong-An Zhang, Jiagang Tu   +4 more
doaj   +2 more sources

Self-assembled nanoparticle vaccine comprised of multiple epitopes provides robust protective immunity against reoviruses in fish model [PDF]

Cell Communication and Signaling
Grass carp reovirus type II (GCRV-II) has inflicted substantial economic damage to aquaculture industry due to highly contagious. To combat epidemic GCRV-II, we rational designed and constructed a multi-epitope nanoparticle vaccine (Pep-Fn) that ...
Fei-Fan Xu, Zhao Zhao, Zhu-Yang Deng, Jia-Lun Tang, Bin Zhu   +4 more
doaj   +2 more sources

The Role of Gut Microbiota in Fish Viral Infection: Mechanisms and Microbiota-Targeted Interventions. [PDF]

Aquac Nutr
Viral diseases represent one of the major threats to the global aquaculture industry. In recent years, the relationship between gut microbiota and viral infections in fish has garnered increasing attention. The gut microbiota contributes critically to fish health and is involved in antiviral defense through immune regulation, secretion of microbial ...
Zhao Q, Shao J, Chen Y, Zhang H.
europepmc   +2 more sources

Sialic acid serves as a functional receptor for grass carp reovirus. [PDF]

PLoS Pathogens
Grass carp reovirus (GCRV) causes hemorrhagic disease and substantial economic losses in the aquaculture of grass carp (Ctenopharyngodon idella), a commercially important fish species in China.
Qian Wang, Zichao Peng, Bin Gui, Yongming Li, Lanjie Liao, Zuoyan Zhu, Yaping Wang, Libo He   +7 more
doaj   +2 more sources