Vaccines, 2021 Grass carp reovirus (GCRV) leads to severe hemorrhagic disease in grass carp (Ctenopharyngodon idella) and causes economic losses in grass carp aquaculture.
Jiyuan Yin, Yingying Li, Weiwei Zeng
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Type II grass carp reovirus utilizes autophagosomes for viroplasm formation and subclinical persistent infection [PDF]
Journal of VirologyGrass carp reovirus (GCRV) is the most virulent pathogen within the genus Aquareovirus, belonging to the family Spinareoviridae. GCRV is categorized into three genotypes, with type II (GCRV-II) being the predominant strain circulating in China ...
Qian Wang +9 more
doaj +2 more sources
Cell surface heparan sulfate is an attachment receptor for grass carp reovirus [PDF]
iScienceSummary: Grass carp reovirus (GCRV) causes hemorrhagic disease in grass carp, leading to significant economic losses in China’s aquaculture. However, the cellular receptors responsible for the initiation of GCRV infection remain unclear.
Qian Wang +8 more
doaj +2 more sources
Piscine Vitamin D Receptors Vdra/Vdrb in the Absence of Vitamin D Are Utilized by Grass Carp Reovirus for Promoting Viral Replication [PDF]
Microbiology Spectrum, 2023 The vitamin D receptor (VDR) plays a pivotal role in the biological actions of vitamin D (VitD). However, little is known about the functions of VDR in the production of viral inclusion bodies (VIBs). Using a representative strain of grass carp reovirus (
Yun Jie Song +6 more
doaj +2 more sources
GCRV 096 VP6 protein and its impacts on GCRV replication with different genotypes in CIK cells
Aquaculture and Fisheries, 2018 Grass carp reovirus (GCRV) is the causative agent of grass carp hemorrhagic disease, which has detrimental effects on the grass carp aquaculture industry. There are four known genotypes of GCRV and strains of different GCRV genotypes differ greatly.
Jichang Jian
exaly +3 more sources
Self-assembled nanoparticle vaccine comprised of multiple epitopes provides robust protective immunity against reoviruses in fish model [PDF]
Cell Communication and SignalingGrass carp reovirus type II (GCRV-II) has inflicted substantial economic damage to aquaculture industry due to highly contagious. To combat epidemic GCRV-II, we rational designed and constructed a multi-epitope nanoparticle vaccine (Pep-Fn) that ...
Fei-Fan Xu +4 more
doaj +2 more sources
GCRV-II Triggers B and T Lymphocyte Apoptosis via Mitochondrial ROS Pathway [PDF]
VirusesGrass carp reovirus (GCRV), particularly the highly prevalent genotype II (GCRV-II), is known to infect peripheral blood leukocytes (PBLs) of grass carp. However, it is unclear whether GCRV-II can induce apoptosis in bystander lymphocytes within infected
Jie Wang +5 more
doaj +2 more sources
Type II Grass Carp Reovirus Rapidly Invades Grass Carp (Ctenopharyngodon idella) via Nostril–Olfactory System–Brain Axis, Gill, and Skin on Head [PDF]
Viruses, 2023 Type II grass carp reovirus (GCRV-II) with high pathogenicity and infectivity causes severe hemorrhagic disease, which leads to extensive death in the grass carp and black carp aquaculture. However, the early invasion portal remains unclear.
Wentao Zhu +5 more
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Sialic acid serves as a functional receptor for grass carp reovirus. [PDF]
PLoS PathogensGrass carp reovirus (GCRV) causes hemorrhagic disease and substantial economic losses in the aquaculture of grass carp (Ctenopharyngodon idella), a commercially important fish species in China.
Qian Wang +7 more
doaj +2 more sources
Grass carp reovirus VP35 hijacks DHX15 into phase-separated inclusion bodies to evade host antiviral immunity [PDF]
Cell Communication and SignalingMany viral proteins undergo liquid-liquid phase separation (LLPS) to form biomolecular condensates known as viral inclusion bodies (VIBs), which are utilized for genome replication and virion assembly, thus serving as potential targets for antiviral ...
Chu Zhang +4 more
doaj +2 more sources