Integrative transcriptome analysis reveals alternative polyadenylation potentially contributes to GCRV early infection [PDF]
Frontiers in Microbiology, 2023 IntroductionGrass carp reovirus (GCRV), a member of the Aquareovirus genus in the Reoviridae family, is considered to be the most pathogenic aquareovirus. Productive viral infection requires extensive interactions between viruses and host cells. However,
Sheng Tan +6 more
doaj +7 more sources
Preliminary study of BF/C2 on immune mechanism of grass carp against GCRV infection [PDF]
BMC GenomicsBF/C2 is a crucial molecule in the coagulation complement cascade pathway and plays a significant role in the immune response of grass carp through the classical, alternative, and lectin pathways during GCRV infection.
Yuling Wei +4 more
doaj +6 more sources
A Novel Subunit Vaccine Based on Outer Capsid Proteins of Grass Carp Reovirus (GCRV) Provides Protective Immunity against GCRV Infection in Rare Minnow (Gobiocypris rarus) [PDF]
Pathogens, 2020 The grass carp hemorrhagic disease, caused by the grass carp reovirus (GCRV), has resulted in severe economic losses in the aquaculture industry in China. VP4 and VP35 are outer capsid proteins of GCRV and can induce an immune response in the host. Here,
Changyong Mu +11 more
doaj +5 more sources
Autophagy Inhibits Grass Carp Reovirus (GCRV) Replication and Protects Ctenopharyngodon idella Kidney (CIK) Cells from Excessive Inflammatory Responses after GCRV Infection [PDF]
Biomolecules, 2020 Autophagy is an essential and highly conserved process in mammals, which is critical to maintaining physiological homeostasis, including cell growth, development, repair, and survival.
Pengfei Chu +7 more
doaj +5 more sources
CRISPR/Cas9 mutagenesis reveals an essential role of PI4KB in promoting growth and resisting hemorrhagic disease caused by GCRV-II infection in juvenile grass carp [PDF]
Water Biology and SecurityFew studies have reported obtaining grass carp resistant to hemorrhagic disease via gene editing in commercial fish. Here, we demonstrate that the expression and activity of grass carp PI4KB (gcPI4KB) are vital for GCRV-I and GCRV-II replication.
Ming Xian Chang, , Xiao Man Wu
exaly +4 more sources
Grass carp SERPINA1 inhibits GCRV infection through degrading CF2
Frontiers in Immunology, 2022 SERPINA1, a member of the serine protease inhibitor family, plays a role in viral infection and inflammation by regulating the activities of serine and cysteine proteases.
Yangyu Li, Liangming Chen, Zuoyan Zhu
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Analysis of GCRV Pathogenesis and Therapeutic Measures Through Proteomic and Metabolomic Investigations in GCRV-Infected Tissues of Grass Carp (Ctenopharyngodon idella). [PDF]
Int J Mol SciHemorrhagic disease caused by grass carp reovirus (GCRV) infection is a major problem affecting the grass carp aquaculture industry. Therefore, inhibiting the spread of GCRV infection is of great economic significance. Herein, we sequenced five tissues (gill, liver, intestine, kidney, and muscle) from grass carp before and after GCRV infection using ...
Xie J +6 more
europepmc +5 more sources
ITGB1b-Deficient Rare Minnows Delay Grass Carp Reovirus (GCRV) Entry and Attenuate GCRV-Triggered Apoptosis [PDF]
International Journal of Molecular Sciences, 2018 Integrin β-1 (ITGB1) is a transmembrane protein belonging to the integrin family and it plays an important role in viral entry. In this study, the itgb1b gene of the rare minnow, Gobiocypris rarus, was cloned and analyzed. To investigate the possible role of itgb1b on grass carp reovirus (GCRV) infection, we generated an ITGB1b-deficient rare minnow ...
Geng Chen +7 more
openaire +4 more sources
Recombinant Baculovirus-Produced Grass Carp Reovirus Virus-Like Particles as Vaccine Candidate That Provides Protective Immunity against GCRV Genotype II Infection in Grass Carp [PDF]
Vaccines, 2021 Grass carp reovirus (GCRV) leads to severe hemorrhagic disease in grass carp (Ctenopharyngodon idella) and causes economic losses in grass carp aquaculture.
Ting Gao +8 more
doaj +4 more sources
Complete nucleotide sequence of the S10 genome segment of grass carp reovirus (GCRV) [PDF]
Diseases of Aquatic Organisms, 2001 Hemorrhagic disease, caused by the grass carp reovirus (GCRV), is one of the major diseases of grass carp in China. Little is known about the structure and function of the gene segments of this reovirus. The S10 genome segment of GCRV was cloned and the complete nucleotide sequence is reported here.
T, Qiu, R H, Lu, J, Zhang, Z Y, Zhu
openaire +4 more sources