Results 11 to 20 of about 909 (176)

Integrative transcriptome analysis reveals alternative polyadenylation potentially contributes to GCRV early infection [PDF]

Frontiers in Microbiology, 2023
IntroductionGrass carp reovirus (GCRV), a member of the Aquareovirus genus in the Reoviridae family, is considered to be the most pathogenic aquareovirus. Productive viral infection requires extensive interactions between viruses and host cells. However,
Sheng Tan, Jie Zhang, Jie Zhang, Yonglin Peng, Wenfei Du, Jingxuan Yan, Qin Fang   +6 more
doaj   +6 more sources

Preliminary study of BF/C2 on immune mechanism of grass carp against GCRV infection [PDF]

BMC Genomics
BF/C2 is a crucial molecule in the coagulation complement cascade pathway and plays a significant role in the immune response of grass carp through the classical, alternative, and lectin pathways during GCRV infection.
Yuling Wei, Yu Xiao, Qiaolin Liu, Zongjun Du, Tiaoyi Xiao   +4 more
doaj   +5 more sources

A Novel Subunit Vaccine Based on Outer Capsid Proteins of Grass Carp Reovirus (GCRV) Provides Protective Immunity against GCRV Infection in Rare Minnow (Gobiocypris rarus) [PDF]

Pathogens, 2020
The grass carp hemorrhagic disease, caused by the grass carp reovirus (GCRV), has resulted in severe economic losses in the aquaculture industry in China. VP4 and VP35 are outer capsid proteins of GCRV and can induce an immune response in the host. Here,
Changyong Mu, Vikram N. Vakharia, Yong Zhou, Nan Jiang, Wenzhi Liu, Yan Meng, Yiqun Li, Mingyang Xue, Jieming Zhang, Lingbing Zeng, Qiwang Zhong, Yuding Fan   +11 more
doaj   +4 more sources

Autophagy Inhibits Grass Carp Reovirus (GCRV) Replication and Protects Ctenopharyngodon idella Kidney (CIK) Cells from Excessive Inflammatory Responses after GCRV Infection [PDF]

Biomolecules, 2020
Autophagy is an essential and highly conserved process in mammals, which is critical to maintaining physiological homeostasis, including cell growth, development, repair, and survival.
Pengfei Chu, Libo He, Rong Huang, Lanjie Liao, Yongming Li, Zuoyan Zhu, Wei Hu, Yaping Wang   +7 more
doaj   +4 more sources

First Investigation of Grass Carp Reovirus (GCRV) Infection in Amphioxus: Insights into Pathological Effects, Transmission, and Transcriptomic Responses [PDF]

Viruses
Amphioxus belongs to the subphylum Cephalochordata and occupies a transitional position in evolution between invertebrates and vertebrates. Due to the lack of viruses suitable for immunostimulation in amphioxus, this study for the first time explored the
Jingyuan Lin, Meng Yang, Huijuan Yang, Guangdong Ji, Zhenhui Liu   +4 more
doaj   +3 more sources

CRISPR/Cas9 mutagenesis reveals an essential role of PI4KB in promoting growth and resisting hemorrhagic disease caused by GCRV-II infection in juvenile grass carp

Water Biology and Security
Few studies have reported obtaining grass carp resistant to hemorrhagic disease via gene editing in commercial fish. Here, we demonstrate that the expression and activity of grass carp PI4KB (gcPI4KB) are vital for GCRV-I and GCRV-II replication.
Xiao Man Wu, Ming Xian Chang
exaly   +4 more sources

Analysis of GCRV Pathogenesis and Therapeutic Measures Through Proteomic and Metabolomic Investigations in GCRV-Infected Tissues of Grass Carp (Ctenopharyngodon idella). [PDF]

Int J Mol Sci
Hemorrhagic disease caused by grass carp reovirus (GCRV) infection is a major problem affecting the grass carp aquaculture industry. Therefore, inhibiting the spread of GCRV infection is of great economic significance. Herein, we sequenced five tissues (gill, liver, intestine, kidney, and muscle) from grass carp before and after GCRV infection using ...
Xie J, Jia Z, Li Y, Liao L, Zhu Z, Wang Y, Huang R.   +6 more
europepmc   +4 more sources

ITGB1b-Deficient Rare Minnows Delay Grass Carp Reovirus (GCRV) Entry and Attenuate GCRV-Triggered Apoptosis [PDF]

International Journal of Molecular Sciences, 2018
Integrin β-1 (ITGB1) is a transmembrane protein belonging to the integrin family and it plays an important role in viral entry. In this study, the itgb1b gene of the rare minnow, Gobiocypris rarus, was cloned and analyzed. To investigate the possible role of itgb1b on grass carp reovirus (GCRV) infection, we generated an ITGB1b-deficient rare minnow ...
Geng Chen, Lv Xiong, Yumeng Wang, Libo He, Rong Huang, Lanjie Liao, Zuoyan Zhu, Yaping Wang   +7 more
openaire   +3 more sources

Complete nucleotide sequence of the S10 genome segment of grass carp reovirus (GCRV) [PDF]

Diseases of Aquatic Organisms, 2001
Hemorrhagic disease, caused by the grass carp reovirus (GCRV), is one of the major diseases of grass carp in China. Little is known about the structure and function of the gene segments of this reovirus. The S10 genome segment of GCRV was cloned and the complete nucleotide sequence is reported here.
T, Qiu, R H, Lu, J, Zhang, Z Y, Zhu
openaire   +3 more sources

Identification and characterization of a novel reovirus strain isolated fromgrass carp (Ctenopharyngodon idella) [PDF]

Virology Journal
Background Grass carp (Ctenopharyngodon idella) hemorrhagic disease (GCHD) is a devastating disease that leads to substantial economic losses in the freshwater aquaculture industry.
Weiguang Kong, Guangyi Ding, Qiushi Zhang, Xinjie Yuan, Yuchao Zhu, Liyuan Ma, Chang Cai, Yong Shi, Qianqian Zhang, Zhen Xu   +9 more
doaj   +2 more sources