Results 11 to 20 of about 954 (183)

Autophagy Inhibits Grass Carp Reovirus (GCRV) Replication and Protects Ctenopharyngodon idella Kidney (CIK) Cells from Excessive Inflammatory Responses after GCRV Infection [PDF]

Biomolecules, 2020
Autophagy is an essential and highly conserved process in mammals, which is critical to maintaining physiological homeostasis, including cell growth, development, repair, and survival.
Pengfei Chu, Libo He, Rong Huang, Lanjie Liao, Yongming Li, Zuoyan Zhu, Wei Hu, Yaping Wang   +7 more
doaj   +4 more sources

A Novel Subunit Vaccine Based on Outer Capsid Proteins of Grass Carp Reovirus (GCRV) Provides Protective Immunity against GCRV Infection in Rare Minnow (Gobiocypris rarus) [PDF]

Pathogens, 2020
The grass carp hemorrhagic disease, caused by the grass carp reovirus (GCRV), has resulted in severe economic losses in the aquaculture industry in China. VP4 and VP35 are outer capsid proteins of GCRV and can induce an immune response in the host. Here,
Changyong Mu, Vikram N. Vakharia, Yong Zhou, Nan Jiang, Wenzhi Liu, Yan Meng, Yiqun Li, Mingyang Xue, Jieming Zhang, Lingbing Zeng, Qiwang Zhong, Yuding Fan   +11 more
doaj   +4 more sources

CRISPR/Cas9 mutagenesis reveals an essential role of PI4KB in promoting growth and resisting hemorrhagic disease caused by GCRV-II infection in juvenile grass carp

Water Biology and Security
Few studies have reported obtaining grass carp resistant to hemorrhagic disease via gene editing in commercial fish. Here, we demonstrate that the expression and activity of grass carp PI4KB (gcPI4KB) are vital for GCRV-I and GCRV-II replication.
Ming Xian Chang, Xiao Man Wu
exaly   +4 more sources

Integrative transcriptome analysis reveals alternative polyadenylation potentially contributes to GCRV early infection [PDF]

Frontiers in Microbiology, 2023
IntroductionGrass carp reovirus (GCRV), a member of the Aquareovirus genus in the Reoviridae family, is considered to be the most pathogenic aquareovirus. Productive viral infection requires extensive interactions between viruses and host cells. However,
Sheng Tan, Jie Zhang, Jie Zhang, Yonglin Peng, Wenfei Du, Jingxuan Yan, Qin Fang   +6 more
doaj   +4 more sources

Analysis of GCRV Pathogenesis and Therapeutic Measures Through Proteomic and Metabolomic Investigations in GCRV-Infected Tissues of Grass Carp (Ctenopharyngodon idella). [PDF]

Int J Mol Sci
Hemorrhagic disease caused by grass carp reovirus (GCRV) infection is a major problem affecting the grass carp aquaculture industry. Therefore, inhibiting the spread of GCRV infection is of great economic significance.
Xie J, Jia Z, Li Y, Liao L, Zhu Z, Wang Y, Huang R.   +6 more
europepmc   +4 more sources

ITGB1b-Deficient Rare Minnows Delay Grass Carp Reovirus (GCRV) Entry and Attenuate GCRV-Triggered Apoptosis [PDF]

International Journal of Molecular Sciences, 2018
Integrin -1 (ITGB1) is a transmembrane protein belonging to the integrin family and it plays an important role in viral entry. In this study, the itgb1b gene of the rare minnow, Gobiocypris rarus, was cloned and analyzed. To investigate the possible role
Huang, Rong, Zuoyan Zhu, Liao, Lanjie, Libo He, Geng Chen, Lanjie Liao, Wang, Yaping, Yaping Wang, Wang, Yumeng, Chen, Geng, Zhu, Zuoyan, Lv Xiong, He, Libo, Rong Huang, Xiong, Lv, Yumeng Wang   +15 more
core   +3 more sources

Complete nucleotide sequence of the S10 genome segment of grass carp reovirus (GCRV) [PDF]

Diseases of Aquatic Organisms, 2001
Hemorrhagic disease, caused by the grass carp reovirus (GCRV), is one of the major diseases of grass carp in China. Little is known about the structure and function of the gene segments of this reovirus.
Lu, RH, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China, Zhu, ZY, Qiu, T, Lu, RH, Zhang, J   +4 more
core   +3 more sources

Grass carp SERPINA1 inhibits GCRV infection through degrading CF2

Frontiers in Immunology, 2022
SERPINA1, a member of the serine protease inhibitor family, plays a role in viral infection and inflammation by regulating the activities of serine and cysteine proteases.
Yangyang Li, Yangyang Li, Liangming Chen, Liangming Chen, Rong Huang, Yangyu Li, Yangyu Li, Cheng Yang, Bin Gui, Bin Gui, Yongming Li, Lanjie Liao, Zuoyan Zhu, Yaping Wang, Yaping Wang   +14 more
doaj   +3 more sources

Identification and characterization of a novel reovirus strain isolated fromgrass carp (Ctenopharyngodon idella) [PDF]

Virology Journal
Background Grass carp (Ctenopharyngodon idella) hemorrhagic disease (GCHD) is a devastating disease that leads to substantial economic losses in the freshwater aquaculture industry.
Weiguang Kong, Guangyi Ding, Qiushi Zhang, Xinjie Yuan, Yuchao Zhu, Liyuan Ma, Chang Cai, Yong Shi, Qianqian Zhang, Zhen Xu   +9 more
doaj   +2 more sources

Grass carp reovirus VP4 manipulates TOLLIP to degrade STING for inhibition of IFN production [PDF]

Journal of Virology
Although fish possess an effective interferon (IFN) system to defend against viral infection, grass carp reovirus (GCRV) still causes epidemic hemorrhagic disease and tremendous economic loss in grass carp.
Yang-Yang Wang, Xue-Li Wang, Zhuo-Cong Li, Can Zhang, Xiao Xu, Bao-Jie Cui, Meng-Ze Tian, Chu-Jing Zhou, Na Xu, Yue Wu, Xiao-Li Yang, Dan-Dan Chen, Long-Feng Lu, Shun Li   +13 more
doaj   +2 more sources