Grass carp SERPINA1 inhibits GCRV infection through degrading CF2
Frontiers in Immunology, 2022 SERPINA1, a member of the serine protease inhibitor family, plays a role in viral infection and inflammation by regulating the activities of serine and cysteine proteases.
Yangyang Li +14 more
doaj +3 more sources
Grass carp reovirus VP4 manipulates TOLLIP to degrade STING for inhibition of IFN production [PDF]
Journal of VirologyAlthough fish possess an effective interferon (IFN) system to defend against viral infection, grass carp reovirus (GCRV) still causes epidemic hemorrhagic disease and tremendous economic loss in grass carp.
Yang-Yang Wang +13 more
doaj +2 more sources
Grass carp catalase inhibits GCRV replication through ROS scavenging-mediated immune suppression and autophagy [PDF]
VirulenceCatalase (CAT) is a key antioxidant enzyme that eliminates reactive oxygen species (ROS), thereby protecting organisms from oxidative stress and maintaining cellular homeostasis.
Xuyang Wang +11 more
doaj +2 more sources
Coordination of oxysterol binding protein 1 and VAP-A/B modulates the generation of cholesterol and viral inclusion bodies to promote grass carp reovirus replication [PDF]
Frontiers in ImmunologySimilar to other RNA viruses, grass carp reovirus, the causative agent of the hemorrhagic disease, replicates in cytoplasmic viral inclusion bodies (VIBs), orchestrated by host proteins and lipids.
Jia Qi Li +8 more
doaj +2 more sources
Selection of functional EPHB2 genotypes from ENU mutated grass carp treated with GCRV [PDF]
BMC Genomics, 2021 Background N-ethyl-N-nitrosourea (ENU) mutagenesis is a useful method for the genetic engineering of plants, and the production of functional mutants in animal models including mice and zebrafish.
Meher un Nissa +3 more
doaj +3 more sources
The destiny of the resistance/susceptibility against GCRV is controlled by epigenetic mechanisms in CIK cells [PDF]
Scientific Reports, 2017 AbstractHemorrhagic disease caused by grass carp reovirus (GCRV) has severely threatened the grass carp (Ctenopharyngodon idella) cultivation industry. It is noteworthy that the resistance against GCRV infection was reported to be inheritable, and identified at both individual and cellular levels.
Xueying Shang +4 more
openaire +4 more sources
Fishes, 2022 Interaction between the chemokine receptor XCR1 and its ligand is closely related to the immune function in animals; however, there are only a few reports on role of XCR1 in the immune system of fish. We aimed to analyze the expression of XCR1 in various
Hailuo Yu +4 more
doaj +2 more sources
Effect of Heat Shock Treatment on the Virulence of Grass Carp Reovirus in Rare Minnow Gobiocypris rarus [PDF]
VirusesThe mode and outcome of fish–virus interactions are influenced by many abiotic factors, among which water temperature is especially important in poikilothermic fish.
Qinwei Ni +3 more
doaj +2 more sources
ATG5 negatively regulates grass carp reovirus-induced immune-inflammatory response by degrading RIG-I and MDA5 [PDF]
Journal of VirologyGrass carp reovirus (GCRV) is the most virulent aquareovirus, inducing hemorrhagic disease that results in significant economic losses for the grass carp aquaculture industry in China.
Pengfei Chu +5 more
doaj +2 more sources
International Journal of Molecular Sciences, 2022 Ferritin possesses an immune function to defend against pathogen infection. To elucidate the immunity-protecting roles of ferritin from Ctenopharyngodon idellus (Ciferritin) against virus infection, the cDNA and promoter sequences of Ciferritin were determined, and the correlations between Ciferrtin expressions and promoter methylation levels were ...
Tiaoyi Xiao +5 more
openaire +3 more sources