Water Biology and SecurityFew studies have reported obtaining grass carp resistant to hemorrhagic disease via gene editing in commercial fish. Here, we demonstrate that the expression and activity of grass carp PI4KB (gcPI4KB) are vital for GCRV-I and GCRV-II replication.
Xiao Man Wu, Ming Xian Chang
exaly +3 more sources
Coordination of oxysterol binding protein 1 and VAP-A/B modulates the generation of cholesterol and viral inclusion bodies to promote grass carp reovirus replication [PDF]
Frontiers in ImmunologySimilar to other RNA viruses, grass carp reovirus, the causative agent of the hemorrhagic disease, replicates in cytoplasmic viral inclusion bodies (VIBs), orchestrated by host proteins and lipids.
Jia Qi Li +8 more
doaj +2 more sources
Selection of functional EPHB2 genotypes from ENU mutated grass carp treated with GCRV [PDF]
BMC Genomics, 2021 Background N-ethyl-N-nitrosourea (ENU) mutagenesis is a useful method for the genetic engineering of plants, and the production of functional mutants in animal models including mice and zebrafish.
Meher un Nissa +3 more
doaj +3 more sources
Effect of Heat Shock Treatment on the Virulence of Grass Carp Reovirus in Rare Minnow Gobiocypris rarus [PDF]
VirusesThe mode and outcome of fish–virus interactions are influenced by many abiotic factors, among which water temperature is especially important in poikilothermic fish.
Qinwei Ni +3 more
doaj +2 more sources
ATG5 negatively regulates grass carp reovirus-induced immune-inflammatory response by degrading RIG-I and MDA5 [PDF]
Journal of VirologyGrass carp reovirus (GCRV) is the most virulent aquareovirus, inducing hemorrhagic disease that results in significant economic losses for the grass carp aquaculture industry in China.
Pengfei Chu +5 more
doaj +2 more sources
Comparative Transcriptomics Analysis Reveals Unique Immune Response to Grass Carp Reovirus Infection in Barbel Chub (Squaliobarbus curriculus) [PDF]
BiologyGrass carp (Ctenopharyngodon idella) and barbel chub (Squaliobarbus curriculus)—both Leuciscinae subfamily species—demonstrate differences in grass carp reovirus (GCRV) infection resistance.
Yuhong Huang +7 more
doaj +2 more sources
Frontiers in Immunology, 2022 Grass carp reovirus (GCRV) is highly infectious and lethal to grass carp, causing huge economic losses to the aquaculture industry annually. Currently, vaccination is the most effective method against viral infections.
Xingchen Huo, Jianguo Su
exaly +3 more sources
Ecotoxicology and Environmental SafetyGrass carp hemorrhagic disease is caused by the grass carp reovirus (GCRV). The disease spreads rapidly and has a high fatality rate, which seriously affects grass carp culture. Moreover, the molecular mechanisms underlying grass carp hemorrhagic disease
Ziming Yuan +2 more
exaly +3 more sources
Grass carp reovirus VP56 and VP35 induce formation of viral inclusion bodies for replication [PDF]
iScienceSummary: Viral inclusion bodies (VIBs) are subcellular structures required for efficient viral replication. How type II grass carp reovirus (GCRV-II), the mainly prevalent strain, forms VIBs is unknown.
Chu Zhang +4 more
doaj +2 more sources
Oral Vaccination of Grass Carp (Ctenopharyngodon idella) with Baculovirus-Expressed Grass Carp Reovirus (GCRV) Proteins Induces Protective Immunity against GCRV Infection [PDF]
Vaccines, 2021 The grass carp reovirus (GCRV) causes severe hemorrhagic disease with high mortality and leads to serious economic losses in the grass carp (Ctenopharyngodon idella) industry in China. Oral vaccine has been proven to be an effective method to provide protection against fish viruses.
Changyong Mu +10 more
openaire +3 more sources