Results 11 to 20 of about 4,527 (165)

TSHR-Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition. [PDF]

Adv Sci (Weinh)
This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Zhang Y, Wu E, Liu W, Zeng L, Ling N, Wang H, Li Z, Yao S, Pan T, Li X, Huang Y, Li X, Tu Y, Yan W, Wu J, Ye M, Wu W.   +16 more
europepmc   +2 more sources

HUBUNGAN FAKTOR RISIKO TERHADAP KEJADIAN OPHTHALMOPATHY GRAVES

Jurnal Kedokteran Diponegoro, 2019
Latar Belakang: Opthalmopathy Graves merupakan salah satu tanda adanya penyakit Graves; penyakit autoimun dengan inflamasi sistemik. OG bisa terjadi pada penyakit Graves yang fungsi tiroidnya hipertiroidisme, eutiroidisme dan hipotiroidisme.
Y. Andressa Nugroho W., Charles Limantoro, A. Kentar Arimadyo   +2 more
doaj   +1 more source

Preventing Graves' Ophthalmopathy [PDF]

New England Journal of Medicine, 1998
Graves' ophthalmopathy and Graves' hyperthyroidism are closely linked, but the precise relation between these different expressions of the same disease is poorly understood.
openaire   +3 more sources

Prolapso de gordura orbitária e oftalmopatia de Graves Orbital fat prolapse and Graves' ophthalmopathy

Revista Brasileira de Oftalmologia, 2009
Relatam-se dois casos clínicos de prolapso de gordura orbitária, sendo um associado à oftalmopatia de Graves. Os pacientes apresentavam em comum exame clínico com elevação na região temporal da órbita direita e aumento da gordura intraorbitária na ...
Kim-Ir-Sen Santos Teixeira, Rachel Campêlo Feres, Gustavo Maurílio do Nascimento Garcia Pereira, Marise Amaral Rebouças Moreira, Dorislay Barbosa de Sousa Camargo Andrade   +4 more
doaj   +1 more source

Ophthalmopathy Consciousness Level in Graves Patients: Graves Ophthalmopathy

Erciyes Tıp Dergisi/Erciyes Medical Journal, 2014
Objective: We aimed to examine the knowledge and consciousness levels of participators about Graves orbitopathy (GO) by conducting an investigation of ophthalmopathy consciousness of Graves patients, providing coordination among all health insti- tutions and ophthalmologists and giving information about the subject to patients. Materials and Methods: A
Kan E.K., Kan E., Ecemiş G.C., Bahadır Ç.T., Çolak R.   +4 more
openaire   +2 more sources

Comparative evaluation of oculometric variables in graves' ophthalmopathy

Clinics, 2009
OBJECTIVES: To estimate oculometric parameters of Graves' ophthalmopathy in comparison to healthy eyes using digital photography and digital image analysis. INTRODUCTION: Graves' ophthalmopathy is the main cause of eye proptosis.
Hélio Amante Miot, Leonardo Parr dos Santos Fernandes, Edson Nassib Jorge, Daniel Rosito Pivotto, Célia Regina Nogueira, Gláucia Maria Ferreira da Silva Mazeto   +5 more
doaj   +1 more source

Practical Guidelines Management of Graves Ophthalmopathy

Acta Medica Indonesiana, 2020
Graves’ ophthalmopathy is the most common extra-thyroid manifestation in patients with Graves’ disease, based on inflammatory and autoimmune conditions in orbital tissue.
Imam Subekti, Pradana Soewondo, Suharko Soebardi, Budiman Darmowidjojo, Dante Saksono Harbuwono, Dyah Purnamasari, Tri Juli Edi Tarigan, Wismandari Wisnu, Dicky Levenus Tahapary, Farid Kurniawan, M Sidik, Syntia Nusanti, Salmarezka Dewiputri, Hernawita Suharko, Gusti G Suardana, Indrati Suroyo, Vally Wulani, Alvita Dewi Siswoyo, Soehartati Gondhowiardjo, Henry Kodrat   +19 more
doaj   +2 more sources

A novel method for quantifying the biomechanical parameters of orbital soft tissue using a corneal dynamic scheimpflug analyser: a retrospective study

BMC Ophthalmology, 2019
Background To demonstrate that the Corvis ST could be used to quantify the biomechanical parameters of the orbital soft tissues by measuring and comparing whole eye movement (WEM) using the Corvis in normal eyes and in eyes of patients with Graves ...
Ho Sik Hwang, Eun Chul Kim, Man Soo Kim, Suk-Woo Yang   +3 more
doaj   +1 more source

Analysis of Foveal and Parafoveal Microvascular Density and Retinal Vessel Caliber Alteration in Inactive Graves’ Ophthalmopathy

Journal of Ophthalmology, 2020
Purpose. We aimed to evaluate foveal and parafoveal density using optical coherence tomography angiography and the alteration on the retinal vessel diameter in patients with inactive Graves’ ophthalmopathy compared to age-matched normal population ...
Cetin Akpolat, Muhammed M. Kurt, Merve Yılmaz, Fikriye Ordulu, Ferhat Evliyaoglu   +4 more
doaj   +1 more source

Graves' ophthalmopathy: interdisciplinary approach

Клиническая и экспериментальная тиреоидология, 2010
Graves' ophthalmopathy constitutes a major therapeutic challenge, so specialists of various disci-plines have to combine their forces. According to the last consensus of EUGOGO (European Group On Graves' Orbitopathy) the treatment of choice for Graves ...

doaj   +1 more source