Results 41 to 50 of about 278,227 (245)

The thyroid, the eyes and the gut: a possible connection [PDF]

, 2017
Graves’ disease (GD) is an autoimmune disorder responsible for 60–90% of thyrotoxicosis, with an incidence of 1 to 2 cases per 1000 population per year in England.
Covelli, D., Ludgate, Marian Elizabeth
core   +2 more sources

The Role of Adipsin, Complement Factor D, in the Pathogenesis of Graves’ Orbitopathy

Investigative Ophthalmology and Visual Science, 2023
Purpose Graves’ orbitopathy (GO) is an orbital manifestation of autoimmune Graves’ disease, and orbital fibroblast is considered a target cell, producing pro-inflammatory cytokines and/or differentiating into adipocytes.
H. Byeon, M. Chae, JaeSang Ko, E. J. Lee, D. Kikkawa, S. Jang, Jina Yoon   +6 more
semanticscholar   +1 more source

Modulating gut microbiota in a mouse model of Graves’ orbitopathy and its impact on induced disease

Microbiome, 2021
Graves’ disease (GD) is an autoimmune condition in which autoantibodies to the thyrotropin receptor (TSHR) cause hyperthyroidism. About 50% of GD patients also have Graves’ orbitopathy (GO), an intractable disease in which expansion of the orbital ...
S. Moshkelgosha, H. Verhasselt, G. Masetti, D. Covelli, F. Biscarini, M. Horstmann, A. Daser, A. Westendorf, Christoph Jesenek, S. Philipp, S. Diaz-Cano, J. Banga, D. Michael, S. Plummer, J. Marchesi, A. Eckstein, M. Ludgate, U. Berchner‐Pfannschmidt, and the Indigo consortium   +18 more
semanticscholar   +1 more source

Antioxidant Therapy in Graves’ Orbitopathy

Frontiers in Endocrinology, 2020
The balance of the cell redox state is a key point for the maintenance of cellular homeostasis. Increased reactive oxygen species (ROS) generation leads to oxidative damage of tissues, which is involved in the development of several diseases, including ...
Giulia Lanzolla, Claudio Marcocci, Michele Marinò   +2 more
doaj   +1 more source

Orbital lymphoma associated with Graves’ disease: A case report [PDF]

Vojnosanitetski Pregled, 2014
Introduction. The presence of bilateral exophthalmos and palpebral, periorbital edema associated with hyperthyroidism is most often considered as an initial sign of Graves’ ophthalmopathy.
Hajduković Zoran, Kuzmić-Janković Snežana, Kljaković-Avramović Tamara, Sekulović Leposava, Tukić Ljiljana   +4 more
doaj   +1 more source

Antithymocyte Globulin as Second-Line Therapy in Graves Orbitopathy—Preliminary Results From a Prospective Single-Center Study

Frontiers in Endocrinology, 2022
ObjectiveManagement of Graves’ orbitopathy remains a challenge. Our previous case report has shown promising results for rabbit antithymocyte globulin (rATG) in the treatment of Graves’ orbitopathy.DesignWe present the response of 7 individuals with ...
Monika Sarnat-Kucharczyk, Maria Świerkot, Gabriela Handzlik, Grażyna Kulawik, Krystyna Jagoda, Iga Grochoła-Małecka, Joanna Fryżewska, Ewa Mrukwa-Kominek, Jerzy Chudek   +8 more
doaj   +1 more source

Exophthalmos in a young woman with no Graves’ disease – a case report of IgG4-related orbitopathy

BMC Ophthalmology, 2018
Background Immunoglobulin G4-related disease (IgG4-rd) is characterized by lymphoplasmacytic infiltration and tissue fibrosis. Orbital manifestations of IgG4-rd may include unilateral or bilateral proptosis, cicatricial extraocular muscle myopathy ...
Annamaria Erdei, Zita Steiber, Csaba Molnar, Ervin Berenyi, Endre V. Nagy   +4 more
doaj   +1 more source

Thyroid Eye Disease due to Immune Reconstitution Inflammatory Syndrome as a Consequence of Antiretroviral Therapy in the Setting of AIDS

Case Reports in Endocrinology, 2020
We describe a case of worsening Graves’ orbitopathy due to immune reconstitution inflammatory syndrome (IRIS) in a 38-year-old HIV-infected male after beginning ART (antiretroviral therapy).
Ravali Nallu, Parvathy Madhavan, Lisa Chirch, Pooja Luthra   +3 more
doaj   +1 more source

Factors Predicting Long-term Outcome and the Need for Surgery in Graves Orbitopathy: Extended Follow-up From the CIRTED Trial

Journal of Clinical Endocrinology and Metabolism, 2023
Graves orbitopathy is both disabling and disfiguring. Medical therapies to reduce inflammation are widely used, but there is limited trial data beyond 18 months of follow-up.
Peter Taylor, R. Rajendram, S. Hanna, Victoria Wilson, J. Pell, Chunhei Li, A. Cook, R. Gattamaneni, N. Plowman, S. Jackson, R. Hills, R. French, J. Uddin, Richard Lee, C. Dayan   +14 more
semanticscholar   +1 more source

Quality of life in Graves' orbitopathy [PDF]

Medicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor", 2011
The quality of life of patients with Graves' orbitopathy (GO) may be seriously damaged due to the changes in appearance, working abilities and everyday activities. The reasons for the deterioration in quality of life in GO are proptosis, diplopiae and/or
Ćirić Jasmina
doaj   +1 more source