Results 151 to 160 of about 18,575 (207)

A Hypoxia-reoxygenation Injury Model in Self-assembling Human Cardioids. [PDF]

J Vis Exp
Parker LE, Thomas MC, Williams AB, Weirnick R, Ogliari AS, Karpurapu A, Barreto C, Manepalli S, Peña KC, Brandt AN, Booth M, Dalal NA, Lou F, Beard AJ, Karra R.   +14 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

<i>Cladosporium cladosporioides</i> Fungemia in a Patient with Non-Hodgkin Lymphoma: An Extremely Rare Case and Review of the Literature. [PDF]

Reports (MDPI)
Niyazi D, Daskalova N, Micheva I, Stoeva T.   +3 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Fungal Spore Detection of the Gray Mold Crop Disease: Imprinted-Polymer Thermometric Sensing Platform for the Real-Time Monitoring of <i>Botrytis cinerea</i>. [PDF]

J Agric Food Chem
Arreguin-Campos R, Marroquin-Garcia R, Parreiras de Jesus AC, Zanzen U, Bosmans L, Huysmans M, Rosiers E, Claes A, Cleij TJ, Eersels K, van Grinsven B.   +10 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Robust multi-target multi-scale tomato leaf disease detection for precision agriculture applications. [PDF]

Front Plant Sci
Pan JZ, Xie Y, Zhao SY, Kang YL, Yin SH, Fan ZQ, Guo LF, Qi LM, Si CJ.   +8 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Biocontrol strategies for fungal diseases of <i>Ganoderma lucidum</i>: from antagonistic microbes and synthetic communities to intelligent technologies. [PDF]

Front Microbiol
Chang X, Jiang X, Wang K, Xu HL, Chen D, Kong M, Liu X.   +6 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source