Results 41 to 50 of about 724,737 (248)
eLifeAlthough grid cells are one of the most well-studied functional classes of neurons in the mammalian brain, whether there is a single orientation and spacing value per grid module has not been carefully tested. We analyze a recent large-scale recording of
William T Redman +3 more
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Representation of nonspatial and spatial information in the lateral entorhinal cortex
Frontiers in Behavioral Neuroscience, 2011 Some theories of memory propose that the hippocampus integrates the individual items and events of experience within a contextual or spatial framework.
Sachin S Deshmukh +3 more
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Frontiers in Synaptic Neuroscience, 2018 Spatial memory processing requires functional interaction between the hippocampus and the medial entorhinal cortex (MEC). The grid cells of the MEC are most abundant in layer II and rely on a complex network of local inhibitory interneurons to generate ...
Jeremiah P. Hartner +2 more
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Probabilistic Learning by Rodent Grid Cells. [PDF]
PLoS Comput Biol, 2016 Mounting evidence shows mammalian brains are probabilistic computers, but the specific cells involved remain elusive. Parallel research suggests that grid cells of the mammalian hippocampal formation are fundamental to spatial cognition but their diverse response properties still defy explanation.
Cheung A.
europepmc +8 more sources
On the optimality of grid cells
CoRR, 2016 Grid cells, discovered more than a decade ago [5], are neurons in the brain of mammals that fire when the animal is located near certain specific points in its familiar terrain. Intriguingly, these points form, for a single cell, a two-dimensional triangular grid, not unlike our Figure 3.
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GABAA Receptor Subunit α3 in Network Dynamics in the Medial Entorhinal Cortex
Frontiers in Systems Neuroscience, 2019 Layer II of the medial entorhinal cortex (MEC LII) contains the largest number of spatially modulated grid cells and is one of the first regions in the brain to express Alzheimer’s disease (AD)-related pathology.
Nina Berggaard +2 more
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A new direction for grid cells [PDF]
Learning & Behavior, 2015 Krupic, Bauza, Burton, Barry, & O'Keefe (Grid cell symmetry is shaped by environmental geometry. Nature, 518, 232-235, 2015) found that the grids of grid cells in the entorhinal cortex of rats become sparser at the sharp end of a trapezoidal space. This makes grids, and grid cells, unsuitable for measuring distance traveled (odometry) and suggests that
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To be a Grid Cell: Shuffling procedures for determining “Gridness” [PDF]
, 2017 Abstract Grid cells in freely behaving mammals are defined by the strikingly regular periodic spatial distribution of their firing. The standard method of identification calculates the “Gridness” of the spatial firing pattern, with significance being defined relative to the 95 th ...
Barry, C., Burgess, N.
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
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Functional properties of stellate cells in medial entorhinal cortex layer II
eLife, 2018 Layer II of the medial entorhinal cortex (MEC) contains two principal cell types: pyramidal cells and stellate cells. Accumulating evidence suggests that these two cell types have distinct molecular profiles, physiological properties, and connectivity ...
David C Rowland +6 more
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