Results 51 to 60 of about 724,737 (248)

Modeling Grid Cell Distortions with a Grid Cell Calibration Mechanism

Cyborg and Bionic Systems
The medial entorhinal cortex of rodents is known to contain grid cells that exhibit precise periodic firing patterns based on the animal’s position, resulting in a distinct hexagonal pattern in space. These cells have been extensively studied due to their potential to unveil the navigational computations that occur within the mammalian brain and ...
Daniel Strauß, Zhenshan Bing, Genghang Zhuang, Kai Huang, Alois Knoll   +4 more
openaire   +3 more sources

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Evaluating State Space Discovery by Persistent Cohomology in the Spatial Representation System

Frontiers in Computational Neuroscience, 2021
Persistent cohomology is a powerful technique for discovering topological structure in data. Strategies for its use in neuroscience are still undergoing development.
Louis Kang, Louis Kang, Boyan Xu, Dmitriy Morozov   +3 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

A model combining oscillations and attractor dynamics for generation of grid cell firing

Frontiers in Neural Circuits, 2012
Different models have been able to account for different features of the data on grid cell firing properties, including the relationship of grid cells to cellular properties and network oscillations. This paper describes a model that combines elements of
Michael E Hasselmo, Mark P. Brandon
doaj   +1 more source

Modeling grid fields instead of modeling grid cells [PDF]

, 2018
A neuron’s firing correlates are defined as the features of the external world to which its activity is correlated. In many parts of the brain, neurons have quite simple such firing correlates. A striking example are grid cells in the rodent medial entorhinal cortex: their activity correlates with the animal’s position in space, defining ‘grid fields ...
Sophie Rosay, Simon Weber 0004, Marcello Mulas   +2 more
openaire   +1 more source

Unique grid cell identification of Croatian official map grids [PDF]

Journal of Maps, 2014
The Unique Grid Cell Identification (UGCI) system was created using the Croatian cartographic map grid system as a basis for development. A short description of the Croatian map grid system is therefore provided. Cartographic map nomenclature is used to uniquely identify map sheets; e.g. grid cells.
Duplančić Leder, Tea, Župan, Robert, Hećimović, Željko   +2 more
openaire   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Continuous attractor dynamics in spatial navigation: from population geometry to flexible computation

Frontiers in Neuroscience
A central computational problem in spatial navigation is how spatial representations remain stable under noise and uncertainty, and update reliable estimations of continuous variables such as head-direction and position, which respectively rely on the ...
Yani Chen, Yani Chen, Mu Hua, Xuelong Sun, Xuelong Sun, Jigen Peng, Jigen Peng   +6 more
doaj   +1 more source

Biomimetic SLAM Algorithm Based on Growing Self-Organizing Map

IEEE Access, 2021
A Biomimetic SLAM Algorithm Based on Growing Self-Organizing Map (GSOM-BSLAM), inspired by spatial cognitive mechanism of mammalian hippocampus, is proposed to resolve uncertainty problems in location identification and lack of real-time performance in ...
Yukun Zhang, Mengyuan Chen, Dehong Tian, Lingmei Ding   +3 more
doaj   +1 more source