Results 81 to 90 of about 6,551 (208)
New insights into non-canonical desensitization of Gq signaling by GRK2/3 expression levels [PDF]
, 2023 Gq-coupled receptors, upon agonist-driven activation, stimulate PLC to produce DAG and release Ca2+ stores. Desensitization of these agonist-bound receptors mediated by GRK2/3 involves sequestration of Gq to these GRKs for membrane anchoring. It has been
Jaiswal, Natasha
core
Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss
Advanced Science, Volume 13, Issue 29, 22 May 2026.. ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao +9 more
wiley +1 more source
Structure-Activity Relationships Studies of GRK2 Peptide inhibitors
, 2012 G protein-coupled receptor kinase 2 (GRK2) regulates cell signaling by promoting agonist-specific desensitization of several metabolism-related GPCRs, including the b-adrenergic receptors, endothelin, and glucose-dependent insulinotropic polypeptides ...
CAROTENUTO, ALFONSO
core
Diabetes/Metabolism Research and Reviews, Volume 42, Issue 4, May 2026.Central illustration: Pathophysiological mechanisms linking diabetes mellitus and cardiovascular disease. Chronic hyperglycaemia, insulin resistance, and low‐grade inflammation contribute to endothelial dysfunction, myocardial fibrosis, and cardiomyocyte apoptosis.
Lilian Anagnostopoulou +13 more
wiley +1 more source
Cloning of GRK2 cDNA from S49 murine lymphoma cells
, 1996 Beta-adrenergic receptor kinase is a member of the G protein-linked receptor kinase (GRK1) family that elicits receptor desensitization. We have cloned GRK2 from S49 mouse lymphoma cells.
P. A. Insel +3 more
core +1 more source
Ferrero et al GRK2 Interactome SupplData.xlsx
, 2022 Supplemental data for "Proteomic and Systemic Analysis of the Cardiomyocyte GRK2 Interactome Uncovers Injury-Dependent Signaling Bias"
Walter J. Koch (8422880) +1 more
core +1 more source
GRK2 desensitizes flow-induced responses in osteoblasts
Genetics and Molecular Research, 2017 Bone desensitization after mechanical loading is essential for bone to adapt to its mechanical environment. However, the desensitization mechanism is unknown. Previous studies suggest that G protein-coupled receptors (GPCRs), including P2Y and parathyroid hormone receptors, play important roles in osteoblast mechanobiology.
Y, Xing, Y, Gu, X, Shan, L, Wang, J, You
openaire +2 more sources
Innate Lymphoid Cells in Tissue Homeostasis and Diseases
MedComm, Volume 7, Issue 5, May 2026.Innate lymphoid cells (ILCs) are a heterogeneous group of immune cells with phenotypic and functional plasticity. ILCs dynamically regulate various immune cell types and play a crucial role in the pathophysiological processes of specific organs during sepsis. Targeting ILCs is a promising strategy for treating sepsis.
Zhenzhen Zhan +7 more
wiley +1 more source
A novel GRK2/HDAC6 interaction modulates cell spreading and motility
, 2015 Cell motility and adhesion involves dynamic microtubule (MT) acetylation/deacetylation, a process regulated by enzymes as HDAC6, a major cytoplasmic α-tubulin deacetylase.
Tapia, Olga +4 more
core +1 more source
Il ruolo di GRK2 nel controllo delle funzioni mitocondriali [PDF]
, 2011 Stimoli metabolici come l’insulina e il fattore di crescita simile all’insulina provocano l’accumulo di GRK2 (G protein Coupled Receptor Kinase 2), che a sua volta, è in grado di indurre insulino resistenza.
Fusco, Anna
core +1 more source