Results 81 to 90 of about 9,380 (213)

Rheological Behavior of Microemulsions

, 2002
We study the stationary and transient behaviors of the microemulsion phase subjected to a shear flow. The system is described by a diffusion-convective equation which generalizes the usual Cahn-Hilliard equation.
Gonnella, Giuseppe, Ruggieri, Marco
core   +1 more source

EFFETTI DELLA TERAPIA CON METOPROLOLO E SFINGOSINA 1 FOSFATO IN UN MODELLO SPERIMENTALE DI SCOMPENSO CARDIACO POST-ISCHEMICO [PDF]

, 2017
Un evento patologico chiave nello Scompenso Cardiaco (SC) è la disregolazione dei recettori β adrenergici cardiaci (βAR) conseguenza dell’iperattivazione da parte delle catecolammine.
D'Amico, Maria Loreta
core   +1 more source

Heart Failure: Epidemiology, Pathophysiology, and Management

MedComm, Volume 7, Issue 3, March 2026.
This article takes calcium homeostasis as the point of departure to provide an overview of heart failure from three perspectives—epidemiology, pathophysiological mechanisms, and management strategies—and summarizes the current unmet needs and future directions in the field. ABSTRACT Heart failure (HF) is one of the leading causes of hospitalization and
Yujian Fan, Zhihua Yang, Qing Li, Meng Sun, Yumeng Pu, Ke Zhao, Yu Bao, Xianliang Wang, Jingyuan Mao, Zhiqiang Zhao   +9 more
wiley   +1 more source

GRK2 Fine-Tunes Circadian Clock Speed and Entrainment via Transcriptional and Post-translational Control of PERIOD Proteins

Cell Reports, 2015
The pacemaker properties of the suprachiasmatic nucleus (SCN) circadian clock are shaped by mechanisms that influence the expression and behavior of clock proteins.
Neel Mehta, Arthur H. Cheng, Cheng-Kang Chiang, Lucia Mendoza-Viveros, Harrod H. Ling, Abhilasha Patel, Bo Xu, Daniel Figeys, Hai-Ying M. Cheng   +8 more
doaj   +1 more source

High-fat diet induces protein kinase A and G-protein receptor kinase phosphorylation of β2 -adrenergic receptor and impairs cardiac adrenergic reserve in animal hearts. [PDF]

, 2017
Key pointsPatients with diabetes show a blunted cardiac inotropic response to β-adrenergic stimulation despite normal cardiac contractile reserve. Acute insulin stimulation impairs β-adrenergically induced contractile function in isolated cardiomyocytes ...
Chiamvimonvat, Nipavan, Fu, Qin, Hu, Yuting, Kim, Sungjin, Li, Ning, Liu, Yongming, Wang, Qingtong, Xiang, Yang K, Xu, Bing   +8 more
core   +2 more sources

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

Advanced Healthcare Materials, Volume 15, Issue 8, 23 February 2026.
This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt, Carsten Hoffmann   +12 more
wiley   +1 more source

Scoring of predicted GRK2 phosphorylation sites in Nedd4-2 [PDF]

Bioinformatics, 2006
Abstract Motivation: Epithelial Na+ channels (ENaC) mediate the transport of sodium (Na) across epithelia in the kidney, gut and lungs and are required for blood pressure regulation. They are inhibited by ubiquitin protein ligases, such as Nedd4-2.
Jonathan W. Arthur, Angeles Sanchez-Perez, David I. Cook   +2 more
openaire   +2 more sources

Progress in RNA‐Targeted Therapeutics for Human Diseases

MedComm, Volume 7, Issue 2, February 2026.
RNA‐targeted therapies are revolutionizing molecular medicine by transitioning from a “protein‐centric” focus to an “RNA‐regulatory network” approach. Leveraging RNA's diverse roles in gene regulation, signaling, and epigenetic modifications, advanced platforms such as ASOs, siRNA, miRNA, mRNA, aptamers, shRNA, and CRISPR/Cas systems are enabling ...
Wangzheqi Zhang, Aimin Jiang, Bin‐Kui Jia, Yuming Jin, Yinghu Chen, Zhaoyu Li, Yan Liao, Haoling Zhang, Zhiheng Lin, Xiao Fang, Linhui Wang   +10 more
wiley   +1 more source

The β-Adrenergic Receptor Kinase (GRK2) Is Regulated by Phospholipids [PDF]

Journal of Biological Chemistry, 1995
The beta-adrenergic receptor kinase (beta ARK) is a member of growing family of G protein coupled receptor kinases (GRKs). beta ARK and other members of the GRK family play a role in the mechanism of agonist-specific desensitization by virtue of their ability to phosphorylate G protein-coupled receptors in an agonist-dependent manner.
J J, Onorato, M E, Gillis, Y, Liu, J L, Benovic, A E, Ruoho   +4 more
openaire   +2 more sources

β-adrenergic receptor responsiveness in aging heart and clinical implications [PDF]

, 2014
Elderly healthy individuals have a reduced exercise tolerance and a decreased left ventricle inotropic reserve related to increased vascular afterload, arterial-ventricular load mismatching, physical deconditioning and impaired autonomic regulation (the ...
Carlo eRengo, Carlo eRengo, Dario eLeosco, Domenico eBonaduce, Gennaro ePagano, Giuseppe eFurgi, Grazia Daniela eFemminella, Graziamaria eCorbi, Klara eKomici, Nicola eFerrara, Nicola eFerrara   +10 more
core   +2 more sources