Results 91 to 100 of about 9,380 (213)
The Automorphism Group of a Domain with an Exponentially Flat Boundary Point [PDF]
, 2010 We study the automorphisms group action on a bounded domain in $\CC^n$ having a boundary point that is exponentially flat. Such a domain typically has a compact automorphism group.
Krantz, Steven G.
core
Signal transduction mechanism of biased ligands at histamine H2 receptors [PDF]
, 2014 7TMRs (seven-transmembrane receptors) exist as conformational collections in which different conformations would lead to differential downstream behaviours such as receptor phosphorylation, G-protein activation and receptor internalization.
Alonso, Natalia +5 more
core +1 more source
Expression Analysis of Selected microRNAs in Diabetes Mellitus Visceral Fat Tissues
Journal of Obesity, Volume 2026, Issue 1, 2026.Purpose MicroRNA (miRNA) profiling of visceral adipose tissue in Type‐2 diabetes mellitus (T2DM) remains limited. We compared the expression of obesity‐associated miRNAs in visceral fat from individuals with T2DM versus metabolically healthy obesity (MHO) and examined Raf kinase inhibitory protein (RKIP) as a candidate miR‐543 target.
Rabeah Al-Temaimi +4 more
wiley +1 more source
Alteration of myocardial GRK2 produces a global metabolic phenotype [PDF]
JCI Insight, 2019 A vast body of literature has established GRK2 as a key player in the development and progression of heart failure. Inhibition of GRK2 improves cardiac function post injury in numerous animal models. In recent years, discovery of several non-canonical GRK2 targets has expanded our view of this kinase.
Benjamin P. Woodall +8 more
openaire +3 more sources
Cognitive Function and Heart Failure: The Role of the Adrenergic System [PDF]
, 2016 Heart Failure (HF) and cognitive impairment (CI) represent two high incident diseases worldwide, with extremely elevated mortality and morbidity rates. Their prevalence is expected to further increase in the next years due to the aging population, thus ...
Candido, Ciro +6 more
core +1 more source
Molecular Oncology, Volume 19, Issue 12, Page 3706-3728, December 2025.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
A New GRK2 Inhibitor for Heart Failure
JACC: Basic to Translational Science[Figure: see text]
Chen Gao, Ningjing Song, Yibin Wang
openaire +2 more sources
GRK2 Is a Novel Modulator of the MALT1 Oncoprotein
Blood, 2016 Abstract Background and Significance: Lymphocyte antigen receptor-dependent stimulation of the NF-κB transcription factor is a key event during the normal adaptive immune response. However, dysregulated activation of these signaling pathways can lead to lymphoma.
Cheng, Jing +10 more
openaire +2 more sources
GRK2 as a novel gene therapy target in heart failure [PDF]
Journal of Molecular and Cellular Cardiology, 2011 Despite significant advances in pharmacological and clinical treatment, heart failure (HF) remains a leading cause of morbidity and mortality worldwide. HF is a chronic and progressive clinical syndrome characterized by a reduction in left ventricular (LV) ejection fraction and adverse remodeling of the myocardium.
Rengo G +3 more
openaire +3 more sources
Pharmacology Research &Perspectives, Volume 13, Issue 6, December 2025.ABSTRACT Inhibition of vasocontraction accounts for side effects in treating voiding symptoms in benign prostatic hyperplasia (BPH). We examined the vasoactivity of compounds previously showing inhibition of prostate smooth muscle contraction. Contractions of porcine renal interlobar and coronary arteries were induced by agonists or electric field ...
Guangyang Liu +6 more
wiley +1 more source