Results 111 to 120 of about 6,551 (208)

Increased Nitric Oxide Bioavailability in Adult GRK2 Hemizygous Mice Protects Against Angiotensin II-Induced Hypertension

, 2013
G protein–coupled receptor kinase 2 (GRK2) is a ubiquitous serine/threonine protein kinase able to phosphorylate and desensitize the active form of several G protein–coupled receptors.
Salaices, Mercedes, Briones, Ana M., Jurado-Pueyo, María, Martínez-Revelles, Sonia, Mayor Menéndez, Federico, Avendaño, María S., Murga, Cristina, Lucas, Elisa, Vila-Bedmar, Rocío   +8 more
core   +1 more source

GRK2: a novel cell-specific regulator of severity and duration of inflammatory pain.

, 2010
Chronic pain associated with inflammation is a common clinical problem, and the underlying mechanisms have only begun to be unraveled. GRK2 regulates cellular signaling by promoting G-protein-coupled receptor (GPCR) desensitization and direct interaction
Deumens, Ronald, Nijboer, Cora, I. J. M. den Hartog, M. A. Nassar, Joosten, Elbert A. J., van Velthoven, Cindy T J, W. Kleibeuker, Heijnen, Cobi J, Joosten, Elbert A J, Kavelaars, Annemieke, R. Deumens, H. L. D. M. Willemen, Willemen, Hanneke L. D. M., C. Nijboer, Dorn, Gerald W, N. Eijkelkamp, C. J. Heijnen, van Velthoven, Cindy T. J., Dorn, Gerald W., II, Nassar, Mohammed A, Wood, John N., E. A. J. Joosten, C. T. J. van Velthoven, G. W. Dorn, J. N. Wood, A. Kavelaars, Willemen, Hanneke L D M, Kleibeuker, Wendy, Eijkelkamp, Niels, Wood, John N, Heijnen, Cobi J., Nassar, Mohammed A., den Hartog, Ilona J M, den Hartog, Ilona J. M.   +33 more
core   +1 more source

Design and synthesis of novel indazole-based GRK2 inhibitors

, 2017
G-protein coupled receptor 2(GRK2) is a serine/threonine kinase that is ubiquitously expressed in many tissues and regulates many intracellular mechanisms.
GIAMPIETRO, FRANCESCO
core  

GRK2 makes trouble: A no-No in portal hypertension [PDF]

Gastroenterology, 2006
David, Semela, Daniel A, Langer, Vijay, Shah   +2 more
openaire   +2 more sources

G-protein coupled receptor kinase-2 regulates the migration of chronic lymphocytic leukaemia cells to sphingosine-1 phosphate in vitro and their trafficking in vivo

Scientific Reports
Disease progression and drug resistance in patients with chronic lymphocytic leukaemia (CLL) depend on signals from the tumour microenvironment in lymphoid sites.
María Chiara Cassarino, Ana Colado, Valeria Sarapura Martinez, Claudio Martines, Alice Bonato, Martin Bertini, Miguel Pavlovksy, Rosario Custidiano, Fernando Raimundo Bezares, Pablo Elías Morande, Mónica Vermeulen, Romina Gamberale, Mirta Giordano, Dimitar G Efremov, Mercedes Borge   +14 more
doaj   +1 more source

GRK2 Protein Mediates the ANRIL, a lncRNA, to Affect the Proliferation and Apoptosis of Kasumi-1 Cells

Frontiers in Bioscience-Landmark
Background: A long non-coding RNAs (LncRNAs) called antisense noncoding RNA in the INK4 locus (ANRIL), has emerged as substantial regulators of cell survival in acute myeloid leukemia (AML).
Siqi Wang, Chengsi Zhang, Huali Hu, Jianxia Xu, Jinxin Zhang, Wu Zhou, Fahua Deng, Yaming Zhang, Chenlong Hu, Yuancheng Liu, Hai Huang, Sixi Wei   +11 more
doaj   +1 more source

Therapeutic Efficacy of a Novel Pharmacologic GRK2 Inhibitor in Multiple Animal Models of Heart Failure

JACC: Basic to Translational Science
Summary: GRK2 is the most prominent G protein-coupled receptor kinase that is upregulated in heart failure (HF), and inhibiting GRK2 has improved cardiac function in mice.
Rajika Roy, PhD, Sarah M. Schumacher, PhD, Haley Christine Murphy, BS, Jessica Grondolsky, Thiele Osvaldt Rosales, PhD, J. Kurt Chuprun, PhD, Erhe Gao, MD, PhD, Huaqing Zhao, PhD, MS, Remus M. Berretta, BS, Alexander R.H. Hobby, PhD, Steven R. Houser, PhD, Larisa V. Avramova, PhD, John J.G. Tesmer, PhD, Walter J. Koch, PhD   +13 more
doaj   +1 more source

GRK2 is required for DEN2-NGC AND HCV propagation.

, 2012
(A) Percentage of infected cells for HuH-7 transfected with control siRNAs or with siRNAs against GRK2, and infected with DEN2-NGC. The error bars represent the standard deviation of 10 wells.
Nicholas J. Barrows (136308), Shelton S. Bradrick (27796), Mariano A. Garcia-Blanco (136317), Caroline Le Sommer (136304), James L. Pearson (136312)   +4 more
core   +1 more source

GRK2 and GRK5—The 2 critical kinases in cardiac pathophysiology

Molecular Pharmacology
G protein-coupled receptor kinases (GRKs) are a class of serine/threonine kinases that shut down active signaling mediated by agonist-bound G protein-coupled receptors. Of all the diseases that arise from dysfunctional G protein-coupled receptor-GRK interactions, this review will focus on the roles of the 2 most highly expressed GRKs in heart failure ...
Rajika, Roy, Walter J, Koch
openaire   +2 more sources

G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitors: Current Trends and Future Perspectives.

, 2016
G-protein-coupled receptor kinase 2 (GRK2) is a G-protein-coupled receptor kinase that is ubiquitously expressed in many tissues and regulates various intracellular mechanisms.
Zappala, Maria, Manuela Guccione,, Sabrina Taliani, Silvana Grasso, Manuela Guccione, Roberta Ettari, TALIANI, SABRINA, Roberta Ettari,, Federico Da Settimo, Maria Zappalà, DA SETTIMO PASSETTI, FEDERICO   +10 more
core   +1 more source