Results 111 to 120 of about 9,380 (213)

Negative impact of β-arrestin-1 on post-myocardial infarction heart failure via cardiac and adrenal-dependent neurohormonal mechanisms [PDF]

, 2014
β-Arrestin (βarr)-1 and β-arrestin-2 (βarrs) are universal G-protein-coupled receptor adapter proteins that negatively regulate cardiac β-adrenergic receptor (βAR) function via βAR desensitization and downregulation.
Bathgate Siryk, Ashley, Cannavo, Alessandro, Dabul, Samalia, DE LUCIA, CLAUDIO, Gao, Erhe, Koch, Walter J, LEOSCO, DARIO, Liccardo, Daniela, Lymperopoulos, Anastasios, Pandya, Krunal, RENGO, GIUSEPPE, Walklett, Karlee   +11 more
core   +1 more source

Development of Inflammatory Immune Response-Related Drugs Based on G Protein-Coupled Receptor Kinase 2

Cellular Physiology and Biochemistry, 2018
G protein-coupled receptor kinase 2 (GRK2), as a vital Ser/Thr kinase, is an important regulatory protein in the inflammatory immune response (IIR) by maintaining the balance between the function of inflammatory immune cells and non-conventional ...
Chenchen Han, Yifan Li, Yang Wang, Dongqian Cui, Tingting Luo, Yuwen Zhang, Yang Ma, Wei  Wei   +7 more
doaj   +1 more source

G-protein-coupled receptor kinase 5 polymorphism and Takotsubo cardiomyopathy. [PDF]

, 2015
BACKGROUND: Takotsubo cardiomyopathy (TTC) is an increasingly reported clinical syndrome that mimics acute myocardial infarction without obstructive coronary artery disease and is characterized by transient systolic dysfunction of the apical and/or ...
Arvigo, L, ASSENNATO, Pasquale, Bova, M, Evola, S, Giambanco, F, Giambanco, S, Guglielmo, M, LIO, Domenico, NOVO, Giuseppina, NOVO, Salvatore, Sutera, MR, VACCARINO, Loredana   +11 more
core   +1 more source

Early intervention of baicalin suppresses obesity-induced adipose tissue fibrotic remodeling through Interfering NF-κB/HIF-1ɑ/GRK2 Signaling Pathway

Phytomedicine Plus
Obesity-induced adipose tissue (AT) fibrosis is difficult to reverse, indicating the importance of early intervention. G protein-coupled receptor kinase 2 (GRK2) is a potential regulator of energy metabolism.
Ying Zeng, Wenting Li, Tingting Ma, Honglei Zhang, Jiaxing Xu, Kang Liu   +5 more
doaj   +1 more source

Effect of the 5-HT4 receptor agonist tegaserod on the expression of GRK2 and GRK6 in the rat gastrointestinal tract

BMC Research Notes, 2018
Objective Tegaserod is a 5-hydroxytryptamine type 4 (5-HT4) receptor agonist, formerly used in treating constipation predominant irritable bowel syndrome, which desensitizes 5-HT4 receptors in rat oesophagus and colon in vitro.
Teshome Nedi, Paul J. White, Ian M. Coupar, Helen R. Irving   +3 more
doaj   +1 more source

miR-181a post-transcriptionally targets GRK2 to limit maladaptive signaling in cardiomyocytes

Frontiers in Cardiovascular Medicine
BackgroundPathological upregulation of G protein-coupled receptor kinase 2 (GRK2) is a hallmark of heart failure and contributes to maladaptive signaling, hypertrophic remodeling, and cardiomyocyte death.
Heidi Cho, Heidi Cho, Melissa Lieu, Erhe Gao, Stephanie M. Kereliuk, Samuel Slone, Thiele Osvaldt Rosales, Christina Liu, Maya Hoteit, Eric Barr, J. Kurt Chuprun, Walter J. Koch   +11 more
doaj   +1 more source

GRK2 and chronic pain

, 2012
G protein coupled receptor kinases (GRKs) regulate the termination of G protein-coupled receptor (GPCR) activation by phosphorylating agonist-occupied GPCRs. Apart from terminating GPCR activation, more evidence emerges in recent years demonstrating that GRKs also interact with multiple intracellular signaling molecules, suggesting novel regulatory ...
Wang, Huijing, Infection & Immunity, Regenerative Medicine and Stem Cells, DDOD, Heijnen, J.J., Kavelaars, AMAA, Eijkelkamp, Niels   +6 more
openaire   +2 more sources

GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade. [PDF]

PLoS Biology
During Hedgehog (Hh) signal transduction in development and disease, the atypical G protein-coupled receptor (GPCR) SMOOTHENED (SMO) communicates with GLI transcription factors by binding the protein kinase A catalytic subunit (PKA-C) and physically ...
Madison F Walker, Jingyi Zhang, William Steiner, Pei-I Ku, Ju-Fen Zhu, Zachary Michaelson, Yu-Chen Yen, Annabel Lee, Alyssa B Long, Mattie J Casey, Abhishek Poddar, Isaac B Nelson, Corvin D Arveseth, Falko Nagel, Ryan Clough, Sarah LaPotin, Kristen M Kwan, Stefan Schulz, Rodney A Stewart, John J G Tesmer, Tamara Caspary, Radhika Subramanian, Xuecai Ge, Benjamin R Myers   +23 more
doaj   +1 more source

Regulatory Role of GRK2 in the TLR Signaling-Mediated iNOS Induction Pathway in Microglial Cells

Frontiers in Pharmacology, 2019
G protein-coupled receptor kinase 2 (GRK2) is a ubiquitous member of the GRK family that restrains cellular activation by G protein-coupled receptor (GPCR) phosphorylation leading to receptor desensitization and internalization, but has been identified ...
Sailesh Palikhe, Wakana Ohashi, Takuya Sakamoto, Kohshi Hattori, Masaaki Kawakami, Tsugunobu Andoh, Hiromi Yamazaki, Yuichi Hattori, Yuichi Hattori   +8 more
doaj   +1 more source

GRK specificity and Gβγ dependency determines the potential of a GPCR for arrestin-biased agonism

Communications Biology
G protein-coupled receptors (GPCRs) are mainly regulated by GPCR kinase (GRK) phosphorylation and subsequent β-arrestin recruitment. The ubiquitously expressed GRKs are classified into cytosolic GRK2/3 and membrane-tethered GRK5/6 subfamilies.
Edda S. F. Matthees, Jenny C. Filor, Natasha Jaiswal, Mona Reichel, Noureldine Youssef, Giulia D’Uonnolo, Martyna Szpakowska, Julia Drube, Gabriele M. König, Evi Kostenis, Andy Chevigné, Amod Godbole, Carsten Hoffmann   +12 more
doaj   +1 more source