Results 121 to 130 of about 6,551 (208)

GRK2 wt Allele [PDF]

, 2020
openaire   +1 more source

Mdm2-Mediated Ubiquitination Plays a Pivotal Role in Differentiating the Endocytic Roles of GRK2 and Arrestin3

Upon activation of certain G protein-coupled receptors, Mdm2 promotes the ubiquitination of both GRK2 and arrestin3. Similar to arrestin3, GRK2 ubiquitination was associated with its endocytic activity and proteasomal degradation.
Xiaohan Zhang, Dooti Kundu, Lulu Peng, Kyeong-Man Kim, Xinru Tian, Shujie Wang   +5 more
core   +1 more source

Effects of paroxetine-mediated inhibition of GRK2 expression on depression and cardiovascular function in patients with myocardial infarction

Neuropsychiatric Disease and Treatment, 2016
Xiuqing Tian,1 Qing Wang,1 Rui Guo,2 Lingling Xu,3 Qin M Chen,4 Yinglong Hou1 1Department of Cardiology, Qianfoshan Hospital of Shandong University, Jinan City, 2Department of Physiology, Nanjing University of Chinese Medicine, Nanjing City, 3College of
Tian X, Wang Q, Guo R, Xu L, Chen Q, Hou Y   +5 more
doaj  

Beyond β-Adrenergic Receptor Brake: Compartment-Selective GRK2 Programs from Heart Failure to Cardio-Oncology. [PDF]

Kinases Phosphatases
Dotson CR, Underwood L, Sato PY.
europepmc   +1 more source

G protein-coupled receptor kinase 3 regulates CCR7 signaling, trafficking, and T cell responses to CCL19 and CCL21. [PDF]

J Biol Chem
Sanchez A, Cardona CI, Kaiser B, Bill CA, Miller ME, Bassuk DW, Wagener BM, Brissette MA, Ibanez D, Llano M, Bill CA, Vines CM.   +11 more
europepmc   +1 more source

Configurational diversity of metabotropic glutamate receptor complexes with beta-arrestins. [PDF]

Nat Commun
Marx DC, Gonzalez-Hernandez AJ, Lee J, Siepe D, Weber WF, Huynh K, Gallo PN, Sharghi Moshtaghin S, Arefin A, Broichhagen J, Kalocsay M, Eliezer D, Levitz J.   +12 more
europepmc   +1 more source

Trastuzumab resistance features GRK2 activation.

We studied whole tumor gene expression in humans with pathologic complete response (pCR) or residual disease (RD) following treatment for HER2+ breast cancer to discover gene expression changes associated with, resulting from or causing resistance to treatment with the HER2-targeted treatment trastuzumab (Herceptin). We identified activation of GRK2 in
openaire   +2 more sources

Pharmacological inhibition of G protein-coupled receptor kinase 2 (GRK2) by paroxetine attenuates acetaminophen-induced hepatotoxicity. [PDF]

Korean J Physiol Pharmacol
Yang D, Moon HW, Kim JW, Kim B.
europepmc   +1 more source

Is GRK2 a new target for cardiovascular disease? [PDF]

Hypertension Research, 2018
Jun-Ichi, Oyama, Koichi, Node
openaire   +2 more sources

GPCR kinases shape ACKR4 functions via differential C-terminal phosphorylation. [PDF]

Nat Commun
Gerken OJ, Warmers R, Hild C, Kielkopf N, Catone N, Bruderer R, Legler DF.   +6 more
europepmc   +1 more source