Results 121 to 130 of about 9,380 (213)

GRK2 makes trouble: A no-No in portal hypertension [PDF]

Gastroenterology, 2006
David, Semela, Daniel A, Langer, Vijay, Shah   +2 more
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GRK2 deficiency is a pain

, 2007
G protein-coupled receptor (GPCR) kinase (GRK)2 regulates the responsiveness of many GPCRS, e.g. CCR1, CCR2, CCR5, neurokinin-1 receptor, and metabotropic glutamate receptors, which are involved in the development of allodynia (pain due to a stimulus which does normally not provoke pain) and hyperalgesia (an increased response to a painful stimulus ...
openaire   +2 more sources

GRK2 and GRK5—The 2 critical kinases in cardiac pathophysiology

Molecular Pharmacology
G protein-coupled receptor kinases (GRKs) are a class of serine/threonine kinases that shut down active signaling mediated by agonist-bound G protein-coupled receptors. Of all the diseases that arise from dysfunctional G protein-coupled receptor-GRK interactions, this review will focus on the roles of the 2 most highly expressed GRKs in heart failure ...
Rajika, Roy, Walter J, Koch
openaire   +2 more sources

GRK2 Protein Mediates the ANRIL, a lncRNA, to Affect the Proliferation and Apoptosis of Kasumi-1 Cells

Frontiers in Bioscience-Landmark
Background: A long non-coding RNAs (LncRNAs) called antisense noncoding RNA in the INK4 locus (ANRIL), has emerged as substantial regulators of cell survival in acute myeloid leukemia (AML).
Siqi Wang, Chengsi Zhang, Huali Hu, Jianxia Xu, Jinxin Zhang, Wu Zhou, Fahua Deng, Yaming Zhang, Chenlong Hu, Yuancheng Liu, Hai Huang, Sixi Wei   +11 more
doaj   +1 more source

Therapeutic Efficacy of a Novel Pharmacologic GRK2 Inhibitor in Multiple Animal Models of Heart Failure

JACC: Basic to Translational Science
Summary: GRK2 is the most prominent G protein-coupled receptor kinase that is upregulated in heart failure (HF), and inhibiting GRK2 has improved cardiac function in mice.
Rajika Roy, PhD, Sarah M. Schumacher, PhD, Haley Christine Murphy, BS, Jessica Grondolsky, Thiele Osvaldt Rosales, PhD, J. Kurt Chuprun, PhD, Erhe Gao, MD, PhD, Huaqing Zhao, PhD, MS, Remus M. Berretta, BS, Alexander R.H. Hobby, PhD, Steven R. Houser, PhD, Larisa V. Avramova, PhD, John J.G. Tesmer, PhD, Walter J. Koch, PhD   +13 more
doaj   +1 more source

GRK2 wt Allele [PDF]

, 2020
openaire   +1 more source

The role of GRK2 in hypertension and regulation of GPR30 [PDF]

, 2012
In the hypertensive state, the expression of G protein-coupled receptor kinase 2 (GRK2) level is elevated. On the other hand, the expression of GPR30, a recently discovered GPCR is greatly impaired. The current study focuses on investigating the roles of these two proteins in regulating G protein signaling under the normal and hypertensive states ...
openaire  

Is GRK2 a new target for cardiovascular disease? [PDF]

Hypertension Research, 2018
Jun-Ichi, Oyama, Koichi, Node
openaire   +2 more sources

Effects of paroxetine-mediated inhibition of GRK2 expression on depression and cardiovascular function in patients with myocardial infarction

Neuropsychiatric Disease and Treatment, 2016
Xiuqing Tian,1 Qing Wang,1 Rui Guo,2 Lingling Xu,3 Qin M Chen,4 Yinglong Hou1 1Department of Cardiology, Qianfoshan Hospital of Shandong University, Jinan City, 2Department of Physiology, Nanjing University of Chinese Medicine, Nanjing City, 3College of
Tian X, Wang Q, Guo R, Xu L, Chen Q, Hou Y   +5 more
doaj  

GRK2 as a potential therapeutic target for septic ARDS

Folia Pharmacologica Japonica, 2015
Wakana, Ohashi, Yuichi, Hattori
openaire   +3 more sources