Results 101 to 110 of about 9,380 (213)

Mitochondrial Dysfunction Contributes to Decompensation in a Zebrafish Model of Isoproterenol‐Induced Heart Failure

Acta Physiologica, Volume 241, Issue 12, December 2025.
ABSTRACT Aim Heart failure is a clinical syndrome where the heart's structural or functional impairment leads to inadequate blood flow to meet the body's metabolic demands. Mitochondrial dysfunction is increasingly recognized as a central contributor underlying the contractile impairment observed in the failing heart.
Manuel Vicente, Aaron García‐Blázquez, Antonio Martínez‐Sielva, Jussep Salgado‐Almario, Joaquín Jordán, Beatriz Domingo, Juan Llopis   +6 more
wiley   +1 more source

Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery

PROTEOMICS, Volume 25, Issue 21-22, Page 102-150, November 2025.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue‐specific interactomes and ...
Kalpana Panneerselvam, Krishna Kumar Tiwari, Luana Licata, Simona Panni, Sylvie Ricard‐Blum, Sucharitha Balu, Susie Huget, Juan Jose Medina Reyes, Eliot Ragueneau, Livia Perfetto, Birgit Meldal, Sandra Orchard, Henning Hermjakob   +12 more
wiley   +1 more source

Cardiac GRK2 and the Communicative Axis Between Heart and Fat

JACC: Basic to Translational Science, 2022
[Figure: see text]
openaire   +2 more sources

Considering the role of Murine double minute 2 in the cardiovascular system [PDF]

, 2019
The E3 ubiquitin ligase Murine double minute 2 (MDM2) is the main negative regulator of the tumor protein p53 (TP53). Extensive studies over more than two decades have confirmed MDM2 oncogenic role through mechanisms both TP53-dependent and TP53 ...
Lam, Brian, Roudier, Emile
core   +1 more source

Cannabinoid CB2 receptor‐mediated analgesia: mechanism‐based insights and therapeutic potential

British Journal of Pharmacology, Volume 182, Issue 21, Page 5090-5118, November 2025.
Agonists of the cannabinoid 2 (CB2) receptor have shown promise for the treatment of pain in a variety of animal models. However, despite current preclinical evidence supporting the use of CB2 agonists for pain, successful translation of findings from preclinical models to human patients is lacking.
Kelsey G. Guenther, Andrea G. Hohmann
wiley   +1 more source

Hepatic GRK2 is dispensable for glucose homeostasis and other key metabolic parameters in mice

Molecular Metabolism
Objective: G-protein-coupled receptor (GPCR) kinases (GRKs) abrogate GPCR signaling by promoting receptor desensitization and internalization. Accumulating evidence suggests that GRK2 represents an important regulator of GPCR-mediated effects on systemic
Antwi-Boasiako Oteng, Srinivas Pittala, Andrea Kliewer, Yishu Qiu, Jürgen Wess   +4 more
doaj   +1 more source

Skeletal muscle myogenesis is regulated by G protein-coupled receptor kinase 2 [PDF]

, 2014
This is a pre-copyedited, author-produced pdf of an article accepted for publication in Journal of Molecular Cell Biology following peer review. The version of record Journal of Molecular Cell Biology 6.4 (2014) is available online at: http://dx.doi.org ...
Ana Ruiz-Gómez, Cristina Murga, Federico Mayor, Iria Nieto-Vázquez, Lucia Garcia-Guerra, Mar Ruiz-Gómez, Margarita Lorenzo, Marta Carrasco-Rando, Marta Cruces-Sande, Mercedes Martín, Rocío Vila-Bedmar, Sonia Fernández-Veledo   +11 more
core   +2 more sources

AP‐1 Is an Initial Convergent Transcriptional Response in Lymphatic Endothelium to VEGF‐C or TNFα

Microcirculation, Volume 32, Issue 8, November 2025.
ABSTRACT Objective The lymphatic vasculature plays a central role in resolving inflammation by draining interstitial fluid, immune cells, and inflammatory mediators. While vascular endothelial growth factor C (VEGF‐C) is a well‐established driver of lymphangiogenesis, the effects of chronic pro‐inflammatory cytokines on lymphatic remodeling remain ...
Ewa A. Kreft, Zuzanna J. Juśkiewicz, Brant E. Isakson   +2 more
wiley   +1 more source

Modulación de la estabilidad de la quinasa de receptores acoplados a proteínas G (GRK2) por la ligasa Mdm2: implicaciones fisiológicas en la migración y la proliferación celular [PDF]

, 2007
Tesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Biología Molecular.
Salcedo de Haro, Alicia
core   +1 more source

Concepts of GPCR-controlled navigation in the immune system

, 2019
G-protein-coupled receptor (GPCR) signaling is essential for the spatiotemporal control of leukocyte dynamics during immune responses. For efficient navigation through mammalian tissues, most leukocyte types express more than one GPCR on their surface ...
Boneschansker L, Brandt SL, Chan EC, Filippo K, Freedman NJ, Hjorto GM, Hons M, Katakai T, Kitayama J, Lemos C, Ley K, Miyabe Y, Moussavi‐Harami SF, Proudfoot AEI, Purvanov V, Rot A, Scheiermann C, Schwarz J, Sokol CL, Sotsios Y, Steury MD, Takeda A, Thiriot A, Tomhave ED, Wang Y, Yanagihara S, Zhang Y   +26 more
core   +1 more source