Results 101 to 110 of about 6,551 (208)
, 2022 The G-protein-coupled receptor kinase 2 (GRK2) is an important regulator of inflammation and pathological macrophage phenotype in a variety of diseases. We hypothesize that Gβγ-GRK2 signaling promotes the early inflammatory response and chondrocyte loss ...
Yoshioka, Natalie +9 more
core +1 more source
Science signaling, 2012 G protein–coupled receptor kinase 2 (GR K2) is a ubiquitous, essential protein kinase that is emerging as an integrative node in many signaling networks. Moreover, changes in GR K2 abundance and activity have been identified in several inflammatory, cardiovascular disease, and tumor contexts, suggesting that those alterations may contribute to the ...
Penela Márquez, Petronila +8 more
openaire +4 more sources
BMC Research Notes, 2018 Objective Tegaserod is a 5-hydroxytryptamine type 4 (5-HT4) receptor agonist, formerly used in treating constipation predominant irritable bowel syndrome, which desensitizes 5-HT4 receptors in rat oesophagus and colon in vitro.
Teshome Nedi +3 more
doaj +1 more source
Cardiac GRK2 and the Communicative Axis Between Heart and Fat
JACC: Basic to Translational Science, 2022 [Figure: see text]
openaire +2 more sources
GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade. [PDF]
PLoS BiologyDuring Hedgehog (Hh) signal transduction in development and disease, the atypical G protein-coupled receptor (GPCR) SMOOTHENED (SMO) communicates with GLI transcription factors by binding the protein kinase A catalytic subunit (PKA-C) and physically ...
Madison F Walker +23 more
doaj +1 more source
, 2013 GPR3-HA WT (A) and ST/A (B) were co-transfected with pcDNA, or GRK2, or GRK2 and β-arrestin-2, or GRK2-K220R, or GRK2-K220R and β-arr-2. Twenty-four hr after transfection, cells were harvested for cAMP EIA.
Lisa M. Mehlmann (427411) +4 more
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Reduced GRK2 level in T cells potentiates chemotaxis and signaling in response to CCL4
, 2004 : Chemokine receptors belong to the family of G-protein-coupled receptors (GPCR). Phosphorylation of GPCR by GPCR kinases (GRKs) is considered to play an important role in desensitization of these receptors.
Maria Stella Lombardi +9 more
core +1 more source
Regulatory Role of GRK2 in the TLR Signaling-Mediated iNOS Induction Pathway in Microglial Cells
Frontiers in Pharmacology, 2019 G protein-coupled receptor kinase 2 (GRK2) is a ubiquitous member of the GRK family that restrains cellular activation by G protein-coupled receptor (GPCR) phosphorylation leading to receptor desensitization and internalization, but has been identified ...
Sailesh Palikhe +8 more
doaj +1 more source
GRK specificity and Gβγ dependency determines the potential of a GPCR for arrestin-biased agonism
Communications BiologyG protein-coupled receptors (GPCRs) are mainly regulated by GPCR kinase (GRK) phosphorylation and subsequent β-arrestin recruitment. The ubiquitously expressed GRKs are classified into cytosolic GRK2/3 and membrane-tethered GRK5/6 subfamilies.
Edda S. F. Matthees +12 more
doaj +1 more source
CXCR4 inhibitor attenuates GRK2 expression induced by high glucose.
, 2013 A: Representative western blots of cardiomyocyte lysates showing the effect of different concentrations of AMD3100 on GRK2 expression. B: Representative western blots of cardiomyocyte lysates showing the effect of AMD3100 on GRK2 expression at different ...
Qiu-Xiong Lin (356999) +12 more
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