Results 61 to 70 of about 436,301 (266)

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Effect of a high carbohydrate pre-exercise meal on metabolic and performance-related parameters in male athletes following two different strategies to improve fat utilization: An exploratory examination

Advanced Exercise and Health Science
The purpose of this additional examination of a larger intervention was to determine the effects of a carbohydrate-rich pre-exercise meal on metabolic and performance-related parameters in a group of male endurance athletes, who had previously followed ...
Denise Zdzieblik, Hilke Jerger, Albert Gollhofer, Daniel König   +3 more
doaj   +1 more source

Paradox of hypercholesterolaemia in highly trained, keto-adapted athletes

BMJ Open Sport & Exercise Medicine, 2018
Objective A growing number of ultra-endurance athletes have switched to a very low-carbohydrate/high-fat eating pattern. We compared markers of cholesterol and the lipoprotein profile in a group of elite ultra-runners consuming a high-carbohydrate (HC ...
Brent C Creighton, Parker Neil Hyde, Carl M Maresh, William J Kraemer, Stephen D Phinney, Jeff S Volek   +5 more
doaj   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Dietary thiamine enhances thiamine transport, carbohydrate absorption, glycolysis, and antioxidant properties in Macrobrachium nipponense when fed a high-carbohydrate diet

Aquaculture Reports
Thiamine serves as a cofactor of key enzymes involved in glucose metabolism, and its regulatory role in high-carbohydrate diet has not been reported in crustaceans.
Yonghui Jian, Jiaxin Song, Zhiyuan Chen, Dongsheng Zhou, Youqin Kong, Yujie Liu, Yixiang Zhang, Hongfeng Bai, Zhili Ding   +8 more
doaj   +1 more source

Nutritional ketosis for mild cognitive impairment in Parkinson's disease: A controlled pilot trial

Clinical Parkinsonism & Related Disorders, 2019
Introduction: Glucose hypometabolism and insulin resistance increase risk for and accelerate progression in Parkinson's disease and neurocognitive disorders.
Robert Krikorian, Marcelle D. Shidler, Suzanne S. Summer, Patrick G. Sullivan, Andrew P. Duker, Richard S. Isaacson, Alberto J. Espay   +6 more
doaj   +1 more source

Neurological, Neurodevelopmental and Treatment Outcomes in Patients With Pyruvate Dehydrogenase Complex Deficiency

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of this study was to characterize intellectual and motor function, neurological features including epilepsy, treatment response, and adaptive behavior in patients with pyruvate dehydrogenase complex deficiency (PDCD) in Sweden.
Antri Savvidou, Colin Reilly, Kalliopi Sofou, Sofia Ygberg, Erik A. Eklund, Karin Naess, Niklas Darin   +6 more
wiley   +1 more source

Recombinant production platform for Group A Streptococcus glycoconjugate vaccines

npj Vaccines
Group A Streptococcus (Strep A) is a human-exclusive bacterial pathogen killing annually more than 500,000 patients, and no current licensed vaccine exists.
Sowmya Ajay Castro, Ian J. Passmore, Didier Ndeh, Helen Alexandra Shaw, Alessandro Ruda, Keira Burns, Sarah Thomson, Rupa Nagar, Kathirvel Alagesan, Mark Reglinski, Kieron Lucas, Sherif Abouelhadid, Ulrich Schwarz-Linek, Fatme Mawas, Göran Widmalm, Brendan W. Wren, Helge C. Dorfmueller   +16 more
doaj   +1 more source

Glucagon‐Like Peptide‐1 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are a relatively new class of drugs that were initially approved by the US Food and Drug Administration to improve glycemic control in patients with type 2 diabetes mellitus and, subsequently, weight reduction in patients with obesity.
Audrey Y. Chang, Farrah J. Mateen
wiley   +1 more source

Dysregulated Cholesterol Metabolism, Chronic Inflammation, and Disability in Severe Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Dysregulated lipid metabolism, which can affect remyelination and neural repair, has not been extensively investigated in progressive multiple sclerosis (PMS). The goal was to examine whether dysregulated cholesterol metabolism was associated with disability in PMS. Methods The study sample comprised 53 Severe PMS patients (Expanded
Taylor R. Wicks, Mujeeb Shittu, Anna Wolska, Diala Ghazal, Bianca Weinstock‐Guttman, Alexander Burnham, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +8 more
wiley   +1 more source