Advanced Healthcare Materials, EarlyView.To dissect how mechanical forces influence intestinal physiology, we developed a stretchable 3D colon‐on‐chip that integrates tunable topography, stiffness and peristalsis‐like motion within a physiologically relevant microenvironment. We showed that stretching is a dominant factor governing epithelial behavior, markedly enhancing proliferation and ...
Moencopi Bernheim‐Dennery +10 more
wiley +1 more source
Serotonin functions as a bidirectional guidance molecule regulating growth cone motility. [PDF]
Cell Mol Life Sci, 2021 Vicenzi S, Foa L, Gasperini RJ.
europepmc +1 more source
Directional Liquid Transport Enabled pH‐Responsive Hierarchical Composite for Enhanced Wound Healing
Advanced Healthcare Materials, EarlyView.A hierarchical composite with a gradient architecture transitioning from hydrophobic to hydrophilic layers integrates diode‐like liquid transport, efficient water absorption, breathability, and mechanical robustness. This device enables a multifunctional therapeutic platform with pH‐responsive dual‐drug release, providing synergistic anti‐inflammatory ...
Baolin Wang +5 more
wiley +1 more source
LRRK2 mediates axon development by regulating Frizzled3 phosphorylation and growth cone-growth cone communication. [PDF]
Proc Natl Acad Sci U S A, 2020 Onishi K +6 more
europepmc +1 more source
A WICB 50th Favorite: Arp2/3 complex is important for filopodia formation, growth cone motility, and neuritogenesis in neuronal cells. [PDF]
Mol Biol Cell, 2021 Aloisio FM.
europepmc +1 more source
Advanced Healthcare Materials, EarlyView.Human periosteum‐derived cell spheroids bioprinted at high density within a hyaluronic acid matrix promote fusion and hypertrophic cartilage formation in vitro. Early encapsulation enhances spheroid interaction and matrix maturation, generating scalable cartilage templates intended for endochondral bone regeneration.
Ane Albillos Sanchez +6 more
wiley +1 more source
Analysis of growth cone extension in standardized coordinates highlights self-organization rules during wiring of the Drosophila visual system. [PDF]
PLoS Genet, 2021 Ji W, Wu LF, Altschuler SJ.
europepmc +1 more source
3D Soft Hydrogels Induce Human Mesenchymal Stem Cells “Deep” Quiescence
Advanced Healthcare Materials, EarlyView.Three‐dimensional soft hydrogels mimicking the bone marrow niche induce deep quiescence in human mesenchymal stem cells. Unlike 2D culture, 3D matrices halt proliferation, regulate cell‐cycle and quiescence markers, and downregulate mTORC1 signaling, preserving stem cell phenotype and therapeutic potential ex vivo.
David Boaventura Gomes +11 more
wiley +1 more source
Neuronal NADPH oxidase 2 regulates growth cone guidance downstream of slit2/robo2. [PDF]
Dev Neurobiol, 2021 Terzi A, Roeder H, Weaver CJ, Suter DM.
europepmc +1 more source