Results 21 to 30 of about 79,814 (290)

An Integrated Cytoskeletal Model of Neurite Outgrowth

open access: yesFrontiers in Cellular Neuroscience, 2018
Neurite outgrowth underlies the wiring of the nervous system during development and regeneration. Despite a significant body of research, the underlying cytoskeletal mechanics of growth and guidance are not fully understood, and the relative ...
Kyle E. Miller   +4 more
doaj   +1 more source

To Stick or Not to Stick: The Multiple Roles of Cell Adhesion Molecules in Neural Circuit Assembly

open access: yesFrontiers in Neuroscience, 2022
Precise wiring of neural circuits is essential for brain connectivity and function. During development, axons respond to diverse cues present in the extracellular matrix or at the surface of other cells to navigate to specific targets, where they ...
Trevor Moreland, Fabienne E. Poulain
doaj   +1 more source

Actin dynamics in growth cones [PDF]

open access: yesThe Journal of Neuroscience, 1991
The mechanism of actin incorporation and turnover in the nerve growth cone was examined by immunoelectron microscopy and low-light-level video microscopy of cultured neurons injected with biotin-labeled actin or fluorescently labeled actin. We first determined the sites of actin incorporation into the cytoskeleton of growth cones by immunoelectron ...
Nobutaka Hirokawa, Shigeo Okabe
openaire   +2 more sources

The Arp2/3 complex, UNC-115/abLIM, and UNC-34/Enabled regulate axon guidance and growth cone filopodia formation in Caenorhabditis elegans

open access: yesNeural Development, 2009
Background While many molecules involved in axon guidance have been identified, the cellular and molecular mechanisms by which these molecules regulate growth cone morphology during axon outgrowth remain to be elucidated.
Lundquist Erik A   +2 more
doaj   +1 more source

Inhibition of Rho GTPases in Invertebrate Growth Cones Induces a Switch in Responsiveness to Retinoic Acid

open access: yesBiomolecules, 2019
During development, growth cones are essential for axon pathfinding by sensing numerous guidance cues in their environment. Retinoic acid, the metabolite of vitamin A, is important for neurite outgrowth during vertebrate development, but may also play a ...
Alysha Johnson   +2 more
doaj   +1 more source

Cue-Polarized Transport of β-actin mRNA Depends on 3′UTR and Microtubules in Live Growth Cones

open access: yesFrontiers in Cellular Neuroscience, 2018
Guidance cues trigger fast responses in axonal growth cones such as directional turning and collapse that require local protein synthesis. An attractive cue-gradient, such as Netrin-1, triggers de novo synthesis of β-actin localized to the near-side ...
Kin-Mei Leung   +5 more
doaj   +1 more source

miR-182 Regulates Slit2-Mediated Axon Guidance by Modulating the Local Translation of a Specific mRNA

open access: yesCell Reports, 2017
During brain wiring, cue-induced axon behaviors such as directional steering and branching are aided by localized mRNA translation. Different guidance cues elicit translation of subsets of mRNAs that differentially regulate the cytoskeleton, yet little ...
Anaïs Bellon   +14 more
doaj   +1 more source

Participation of L-Lactate and Its Receptor HCAR1/GPR81 in Neurovisual Development

open access: yesCells, 2021
During the development of the retina and the nervous system, high levels of energy are required by the axons of retinal ganglion cells (RGCs) to grow towards their brain targets.
Samuel Laroche   +5 more
doaj   +1 more source

Translational regulation in growth cones [PDF]

open access: yesCurrent Opinion in Genetics & Development, 2011
Axonal growth cones (GCs) steer in response to extrinsic cues using mechanisms that include local protein synthesis. This adaptive form of gene regulation occurs with spatial precision and depends on subcellular mRNA localisation. Recent genome-wide studies have shown unexpectedly complex and dynamically changing mRNA repertoires in growing axons and ...
Hosung Jung   +2 more
openaire   +4 more sources

The Role of Apoptotic Signaling in Axon Guidance

open access: yesJournal of Developmental Biology, 2018
Navigating growth cones are exposed to multiple signals simultaneously and have to integrate competing cues into a coherent navigational response. Integration of guidance cues is traditionally thought to occur at the level of cytoskeletal dynamics ...
Riley Kellermeyer   +3 more
doaj   +1 more source

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