Results 331 to 340 of about 6,589,084 (383)
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Annals of Internal Medicine, 1980
Humoral regulation of somatic and hematopoietic cell growth has been intensely investigated during the past decade. Growth hormone is unique because it regulates the size of the person within the constraints of the genetic program. The somatomedins and insulin growth factors are low molecular weight polypeptides believed to mediate some functions of ...
DAVID W. GOLDE +3 more
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Humoral regulation of somatic and hematopoietic cell growth has been intensely investigated during the past decade. Growth hormone is unique because it regulates the size of the person within the constraints of the genetic program. The somatomedins and insulin growth factors are low molecular weight polypeptides believed to mediate some functions of ...
DAVID W. GOLDE +3 more
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Growth Factors and Growth Factor Inhibitors
1997This chapter will outline novel treatment strategies predicated on the modulation of growth factor or cytokine-mediated signal transduction pathways. Several excellent recent monographs have addressed this tissue from the point of view of inhibitors of individual pathway constituents (1,2).The current focus will be on defining the pathways potentially ...
Dan L. Longo, Edward A. Sausville
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British Medical Bulletin, 1989
The existence of fibroblast growth factors (FGFs) was proposed over 40 years ago to account for the ability of tissue extracts to stimulate fibroblast proliferation. In the 1970s it became clear that preparations containing FGF activity were in fact pleiotropic, affecting the growth and function of a wide variety of mesenchymal, endocrine and neural ...
Andrew Baird, Patricia A. Walicke
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The existence of fibroblast growth factors (FGFs) was proposed over 40 years ago to account for the ability of tissue extracts to stimulate fibroblast proliferation. In the 1970s it became clear that preparations containing FGF activity were in fact pleiotropic, affecting the growth and function of a wide variety of mesenchymal, endocrine and neural ...
Andrew Baird, Patricia A. Walicke
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Life Sciences, 1974
Publisher Summary This chapter discusses the structure of nerve growth factor (NGF). The amino acid sequence of mouse NGF exhibited significant structural relatedness with the family of insulins and proinsulins. The sequence of mouse NGF could be aligned with human proinsulin with only five deletions required to yield the maximum homology of 21 ...
Ruth A. Hogue-Angeletti +6 more
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Publisher Summary This chapter discusses the structure of nerve growth factor (NGF). The amino acid sequence of mouse NGF exhibited significant structural relatedness with the family of insulins and proinsulins. The sequence of mouse NGF could be aligned with human proinsulin with only five deletions required to yield the maximum homology of 21 ...
Ruth A. Hogue-Angeletti +6 more
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Growth factors and their receptors
Current Opinion in Cell Biology, 1989The growth of cells in culture is controlled by polypeptide hormones that stimulate or inhibit proliferation. More than 20 different growth factors have been extensively characterised, and the corresponding cDNAs have been cloned (Table 1). Several additional growth factors are known from their biological activities but have not yet been structurally ...
B. Westermark, Carl-Henrik Heldin
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Neurological Sciences, 2003
Recent studies have provided new insights on the identity and mechanisms of action of growth factors implicated in myelination processes. Members of several different families of growth factors have been shown to affect oligodendrocyte survival, proliferation and differentiation and their manipulation in the experimental animal provides a means to ...
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Recent studies have provided new insights on the identity and mechanisms of action of growth factors implicated in myelination processes. Members of several different families of growth factors have been shown to affect oligodendrocyte survival, proliferation and differentiation and their manipulation in the experimental animal provides a means to ...
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Growth Hormone, Growth Factors and Hematopoiesis
Hormone Research, 1996Hypocellularity of primary lymphoid organs is a distinctive and reproducible characteristic of aged humans and animals. Similar changes have been reported in both hypophysectomized and dwarf rodents. In the bone marrow of these animals, there is an associated reduction in the number of erythroid, lymphoid and myeloid elements.
Kelley, K.W. +4 more
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Growth factors and growth control
Current Opinion in Cell Biology, 1990Polypeptide growth factors are thought to govern a variety of physiological processes such as cell growth, differentiation, embryogenesis, hematopoiesis, and wound repair. Although it is well documented that growth factors are required for cell proliferation in tissue-culture systems, current knowledge of their in uivo functions is still meager.
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Seminars in Fetal and Neonatal Medicine, 2007
Neuroprotective strategies can prevent lesions from getting worse but agents that have neurotrophic properties can also affect repair in a developing brain. Although prevention and treatment in the early stages of brain lesions are desirable, delayed cell death or improved post-lesion plasticity are the only realistic targets in many cases.
Stéphane Sizonenko +3 more
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Neuroprotective strategies can prevent lesions from getting worse but agents that have neurotrophic properties can also affect repair in a developing brain. Although prevention and treatment in the early stages of brain lesions are desirable, delayed cell death or improved post-lesion plasticity are the only realistic targets in many cases.
Stéphane Sizonenko +3 more
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Growth Factors, Growth-Factor Receptors and Oncogenes
Bio/Technology, 1985In this review we summarize the current knowledge of polypeptide growth factors, their receptors and oncogenes. Recent studies indicate that oncogenes are linked to growth factors and to growth factor receptors, suggesting that these molecules participate in the proliferation of normal and neoplastic cells.
A. Avivi +3 more
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