Results 71 to 80 of about 3,184,534 (315)

Davunetide (NAP) as a preventative treatment for central nervous system complications in a diabetes rat model

Neurobiology of Disease, 2011
Aims: Central nervous system complications including cognitive impairment are an early manifestation of diabetes mellitus, also evident in animal models. NAP (generic name, davunetide), a neuroprotective peptide was tested here for its ability to prevent
Anat Idan-Feldman, Yulie Schirer, Eleni Polyzoidou, Olga Touloumi, Roza Lagoudaki, Nikolaos C. Grigoriadis, Illana Gozes   +6 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Factors affecting the growth of the midface : Proceedings of a sponsored symposium honoring Professor Robert E. Moyers, held February 6 and 7, 1976, in Ann Arbor, Michigan

, 1976
http://babel.hathitrust.org/cgi/pt?id=mdp.39015006456928;view=2up;ui=fullscreen#page/n0/mode ...
Symposium on Craniofacial Growth
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Human placental growth hormone is increased in maternal serum at 20 weeks of gestation in pregnancies with large-for-gestational-age babies

, 2016
To investigate the relationship between maternal serum concentrations of placental growth hormone (GH-V), insulin-like growth factor (IGF)-1 and 2, IGF binding proteins (IGFBP)-1 and 3 and birth weight in appropriate-for-gestational-age (AGA), large-for ...
Liao, S, Jones, B, Taylor, Rennae, Baker, Philip, Fraser, Mhoyra, Perry, Johanna, McCowan, Lesley, Vickers, Mark   +7 more
core   +1 more source

Scaling up production of recombinant human basic fibroblast growth factor in an Escherichia coli BL21(DE3) plysS strain and evaluation of its pro-wound healing efficacy

Frontiers in Pharmacology
Introduction: Human basic fibroblast growth factor (hbFGF) is a highly valuable multifunctional protein that plays a crucial role in various biological processes.
Le Li, Le Li, Bingjie Yu, Bingjie Yu, Yingji Lai, Siyuan Shen, Yawei Yan, Guojun Dong, Xiangyun Gao, Yanrong Cao, Caojie Ge, Liqin Zhu, Liqin Zhu, Huan Liu, Shanhui Tao, Zhiang Yao, Shijun Li, Xiaojie Wang, Xiaojie Wang, Qi Hui, Qi Hui   +20 more
doaj   +1 more source

Esthetic soft tissue ridge augmentation around dental implant: Case report

Saudi Dental Journal, 2011
The aim of this case report is to present a method to correct soft tissue ridge deformity around dental implant using acellular dermal matrix (ADM). A 25-year-old female patient presented with a missing maxillary first left premolar, which had class I ...
Khalid S. Al-Hamdan
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Insulin-like growth factor-1 prevents Aβ[25-35] / (H2O2)-induced apoptosis in lymphocytes by reciprocal NF-κB activation and p53 inhibition via PI3K-dependent pathway

, 2006
The role of insulin-like growth factor (IGF-1) as neural survival factor for the treatment of Alzheimer’s disease has recently gained attention. The present study shows that IGF-1 protects lymphocytes from (10, 30 mM) Ab[25–35] and (25, 50, 100mM) H2O2 ...
Vélez Pardo, Carlos Alberto, Jiménez del Río, Marlene   +1 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source