Growth Hormone-Releasing Hormone in Diabetes [PDF]
Frontiers in Endocrinology, 2016 Growth hormone-releasing hormone (GHRH) is produced by the hypothalamus and stimulates growth hormone synthesis and release in the anterior pituitary gland.
Leonid Evsey Fridlyand +3 more
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Structural basis for activation of the growth hormone-releasing hormone receptor [PDF]
Nature Communications, 2020 Growth hormone-releasing hormone (GHRH) controls metabolism and tissue growth through binding to the cognate receptor (GHRHR). Here authors report the structure of the human GHRHR bound to its endogenous ligand and the stimulatory G protein which reveals
Fulai Zhou +21 more
doaj +3 more sources
Growth Hormone-Releasing Hormone in Endothelial Inflammation.
Endocrinology, 2022 The discovery of hypothalamic hormones propelled exciting advances in pharmacotherapy and improved life quality worldwide. Growth hormone-releasing hormone (GHRH) is a crucial element in homeostasis maintenance, and regulates the release of growth ...
Barabutis N +3 more
europepmc +2 more sources
Growth hormone-releasing hormone receptor signaling in experimental ocular inflammation and neuroprotection [PDF]
Neural Regeneration Research, 2022 Both inflammation and anti-inflammation are involved in the protection of retinal cells. Antagonists of the hypothalamic growth hormone-releasing hormone receptor (GHRHR) have been shown to possess potent anti-inflammatory properties in experimental ...
Ling-Ping Cen +3 more
doaj +2 more sources
Acromegaly Caused by Ectopic Growth Hormone Releasing Hormone Secretion: A Review [PDF]
Frontiers in Endocrinology, 2022 IntroductionEctopic acromegaly is a rare condition caused most frequently by growth hormone releasing hormone (GHRH) secretion from neuroendocrine tumors.
Iga Zendran +4 more
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Growth hormone releasing hormone signaling promotes Th17 cell differentiation and autoimmune inflammation [PDF]
Nature Communications, 2023 Dysregulation of Th17 cell differentiation and pathogenicity contributes to multiple autoimmune and inflammatory diseases. Previously growth hormone releasing hormone receptor (GHRH-R) deficient mice have been reported to be less susceptible to the ...
Lin Du +11 more
doaj +2 more sources
Synthesis and characterization of novel ssDNA X-aptamers targeting Growth Hormone Releasing Hormone (GHRH). [PDF]
PLoS ONE, 2022 BackgroundGrowth Hormone Releasing Hormone (GHRH), 44 amino acids containing hypothalamic hormone, retains the biological activity by its first 29 amino acids.
Burcu Ayhan-Sahin +4 more
doaj +3 more sources
Effect of growth hormone releasing hormone on chondrocytes of osteoarthritis [PDF]
The Korean Journal of Internal Medicine, 2022 Background/Aims To evaluate the effect and possible mechanism of growth hormone releasing hormone (GHRH) on chondrocytes of osteoarthritis (OA). Methods Articular chondrocytes were cultured and the expression of GHRH receptor in chondrocytes was detected.
Zhuoran LI, Yao LI
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Growth hormone-releasing hormone agonist attenuates vascular calcification in diabetic db/db mice [PDF]
Frontiers in Cardiovascular Medicine, 2023 IntroductionVascular calcification (VC) is an independent risk factor for cardiovascular diseases. VC increases mortality of all-causes. VC is one of most common cardiovascular complications in type II diabetes.
Hao-Lin Ren +18 more
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Growth Hormone-Releasing Hormone*
Endocrine Reviews, 1986 The identification of GRH has been followed by an extraordinarily rapid rate of knowledge accumulation. Within a period of slightly more than 3 yr since the structure of the GRH was determined, nearly 500 papers have been published pertaining to the hormone. Extensive knowledge of its anatomy, chemistry, molecular biology, physiology, and pathology has
Lawrence A. Frohman, John-Olov Jansson
semanticscholar +10 more sources