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Growth hormone-releasing hormone receptor signaling in experimental ocular inflammation and neuroprotection [PDF]

open access: yesNeural Regeneration Research, 2022
Both inflammation and anti-inflammation are involved in the protection of retinal cells. Antagonists of the hypothalamic growth hormone-releasing hormone receptor (GHRHR) have been shown to possess potent anti-inflammatory properties in experimental ...
Ling-Ping Cen   +3 more
doaj   +2 more sources

Growth Hormone-Releasing Hormone in Diabetes [PDF]

open access: yesFrontiers in Endocrinology, 2016
Growth hormone-releasing hormone (GHRH) is produced by the hypothalamus and stimulates growth hormone synthesis and release in the anterior pituitary gland.
Leonid Evsey Fridlyand   +3 more
doaj   +4 more sources

Acromegaly Caused by Ectopic Growth Hormone Releasing Hormone Secretion: A Review [PDF]

open access: yesFrontiers in Endocrinology, 2022
IntroductionEctopic acromegaly is a rare condition caused most frequently by growth hormone releasing hormone (GHRH) secretion from neuroendocrine tumors.
Iga Zendran   +4 more
doaj   +2 more sources

Growth hormone releasing hormone signaling promotes Th17 cell differentiation and autoimmune inflammation [PDF]

open access: yesNature Communications, 2023
Dysregulation of Th17 cell differentiation and pathogenicity contributes to multiple autoimmune and inflammatory diseases. Previously growth hormone releasing hormone receptor (GHRH-R) deficient mice have been reported to be less susceptible to the ...
Lin Du   +11 more
doaj   +2 more sources

Effect of growth hormone releasing hormone on chondrocytes of osteoarthritis [PDF]

open access: yesThe Korean Journal of Internal Medicine, 2022
Background/Aims To evaluate the effect and possible mechanism of growth hormone releasing hormone (GHRH) on chondrocytes of osteoarthritis (OA). Methods Articular chondrocytes were cultured and the expression of GHRH receptor in chondrocytes was detected.
Zhuoran LI, Yao LI
doaj   +2 more sources

Growth hormone-releasing hormone agonist attenuates vascular calcification in diabetic db/db mice [PDF]

open access: yesFrontiers in Cardiovascular Medicine, 2023
IntroductionVascular calcification (VC) is an independent risk factor for cardiovascular diseases. VC increases mortality of all-causes. VC is one of most common cardiovascular complications in type II diabetes.
Hao-Lin Ren   +18 more
doaj   +2 more sources

Synthesis and characterization of novel ssDNA X-aptamers targeting Growth Hormone Releasing Hormone (GHRH). [PDF]

open access: yesPLoS ONE, 2022
BackgroundGrowth Hormone Releasing Hormone (GHRH), 44 amino acids containing hypothalamic hormone, retains the biological activity by its first 29 amino acids.
Burcu Ayhan-Sahin   +4 more
doaj   +3 more sources

Growth Hormone-Releasing Hormone in Lung Physiology and Pulmonary Disease [PDF]

open access: yesCells, 2020
Growth hormone-releasing hormone (GHRH) is secreted primarily from the hypothalamus, but other tissues, including the lungs, produce it locally.
Chongxu Zhang   +6 more
doaj   +2 more sources

Structural basis for activation of the growth hormone-releasing hormone receptor [PDF]

open access: yesNature Communications, 2020
Growth hormone-releasing hormone (GHRH) controls metabolism and tissue growth through binding to the cognate receptor (GHRHR). Here authors report the structure of the human GHRHR bound to its endogenous ligand and the stimulatory G protein which reveals
Fulai Zhou   +21 more
doaj   +2 more sources

Protective Activities of Growth Hormone-Releasing Hormone Antagonists against Toxin-Induced Endothelial Injury [PDF]

open access: yesEndocrines
GHRH regulates the secretion of GH from the anterior pituitary gland, previously associated with cancer progression and inflammation. An emerging body of evidence suggests that GHRHAnt support endothelial barrier function, but the mechanisms mediating ...
Saikat Fakir, Nektarios Barabutis
doaj   +2 more sources

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