Growth Hormone-Releasing Hormone in Diabetes [PDF]
Growth hormone-releasing hormone (GHRH) is produced by the hypothalamus and stimulates growth hormone synthesis and release in the anterior pituitary gland.
Leonid Evsey Fridlyand+3 more
doaj +5 more sources
Structural basis for activation of the growth hormone-releasing hormone receptor [PDF]
Growth hormone-releasing hormone (GHRH) controls metabolism and tissue growth through binding to the cognate receptor (GHRHR). Here authors report the structure of the human GHRHR bound to its endogenous ligand and the stimulatory G protein which reveals
Fulai Zhou+21 more
doaj +3 more sources
Growth Hormone-Releasing Hormone in Endothelial Inflammation.
The discovery of hypothalamic hormones propelled exciting advances in pharmacotherapy and improved life quality worldwide. Growth hormone-releasing hormone (GHRH) is a crucial element in homeostasis maintenance, and regulates the release of growth ...
Barabutis N+3 more
europepmc +2 more sources
Growth hormone-releasing hormone receptor signaling in experimental ocular inflammation and neuroprotection [PDF]
Both inflammation and anti-inflammation are involved in the protection of retinal cells. Antagonists of the hypothalamic growth hormone-releasing hormone receptor (GHRHR) have been shown to possess potent anti-inflammatory properties in experimental ...
Ling-Ping Cen+3 more
doaj +2 more sources
Growth hormone response to growth hormone-releasing peptide-2 in growth hormone-deficient Little mice [PDF]
OBJECTIVE: To investigate a possible direct, growth hormone-releasing, hormone-independent action of a growth hormone secretagogue, GHRP-2, in pituitary somatotroph cells in the presence of inactive growth hormonereleasing hormone receptors.
Cibele N. Peroni+7 more
doaj +4 more sources
Novel mechanisms of growth hormone regulation: growth hormone-releasing peptides and ghrelin [PDF]
Growth hormone secretion is classically modulated by two hypothalamic hormones, growth hormone-releasing hormone and somatostatin. A third pathway was proposed in the last decade, which involves the growth hormone secretagogues.
A.-M.J. Lengyel
doaj +3 more sources
Acromegaly Caused by Ectopic Growth Hormone Releasing Hormone Secretion: A Review [PDF]
IntroductionEctopic acromegaly is a rare condition caused most frequently by growth hormone releasing hormone (GHRH) secretion from neuroendocrine tumors.
Iga Zendran+4 more
doaj +2 more sources
Growth hormone releasing hormone signaling promotes Th17 cell differentiation and autoimmune inflammation [PDF]
Dysregulation of Th17 cell differentiation and pathogenicity contributes to multiple autoimmune and inflammatory diseases. Previously growth hormone releasing hormone receptor (GHRH-R) deficient mice have been reported to be less susceptible to the ...
Lin Du+11 more
doaj +2 more sources
Synthesis and characterization of novel ssDNA X-aptamers targeting Growth Hormone Releasing Hormone (GHRH). [PDF]
BackgroundGrowth Hormone Releasing Hormone (GHRH), 44 amino acids containing hypothalamic hormone, retains the biological activity by its first 29 amino acids.
Burcu Ayhan-Sahin+4 more
doaj +3 more sources
Growth hormone-releasing hormone agonist attenuates vascular calcification in diabetic db/db mice [PDF]
IntroductionVascular calcification (VC) is an independent risk factor for cardiovascular diseases. VC increases mortality of all-causes. VC is one of most common cardiovascular complications in type II diabetes.
Hao-Lin Ren+18 more
doaj +2 more sources