Actions and Potential Therapeutic Applications of Growth Hormone-Releasing Hormone Agonists. [PDF]
Endocrinology, 2019 In this article, we briefly review the identification of GHRH, provide an abridged overview of GHRH antagonists, and focus on studies with GHRH agonists. Potent GHRH agonists of JI and MR class were synthesized and evaluated biologically.
Andrew V. Schally +5 more
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Effect of growth hormone releasing hormone on chondrocytes of osteoarthritis [PDF]
The Korean Journal of Internal Medicine, 2022 Background/Aims To evaluate the effect and possible mechanism of growth hormone releasing hormone (GHRH) on chondrocytes of osteoarthritis (OA). Methods Articular chondrocytes were cultured and the expression of GHRH receptor in chondrocytes was detected.
Zhuoran LI, Yao LI
doaj +2 more sources
Growth Hormone-Releasing Hormone*
Endocrine Reviews, 1986 The identification of GRH has been followed by an extraordinarily rapid rate of knowledge accumulation. Within a period of slightly more than 3 yr since the structure of the GRH was determined, nearly 500 papers have been published pertaining to the hormone. Extensive knowledge of its anatomy, chemistry, molecular biology, physiology, and pathology has
Lawrence A. Frohman, John-Olov Jansson
semanticscholar +10 more sources
Growth Hormone-Releasing Hormone in Lung Physiology and Pulmonary Disease [PDF]
Cells, 2020 Growth hormone-releasing hormone (GHRH) is secreted primarily from the hypothalamus, but other tissues, including the lungs, produce it locally.
Chongxu Zhang +6 more
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Growth hormone-releasing hormone attenuates cardiac hypertrophy and improves heart function in pressure overload-induced heart failure [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2017 It has been shown that growth hormone-releasing hormone (GHRH) reduces cardiomyocyte (CM) apoptosis, prevents ischemia/reperfusion injury, and improves cardiac function in ischemic rat hearts.
Alloatti, Giuseppe +18 more
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The Decreased Growth Hormone Response to Growth Hormone Releasing Hormone in Obesity Is Associated to Cardiometabolic Risk Factors [PDF]
Mediators of Inflammation, 2010 The aim of the present study was to evaluate the relationship between GHRH-induced GH secretion in obese premenopausal women and cardiovascular risk markers or insulin resistance. Premenopausal obese women, aged 35–52 years, were studied.
Fernando Cordido +4 more
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Pituitary hypoplasia and growth hormone deficiency in a woman with glycogen storage disease type Ia: a case report [PDF]
Journal of Medical Case Reports, 2008 Introduction Growth retardation is one of the cardinal manifestations of glycogen storage disease type Ia. It is unclear which component of the growth hormone and/or insulin-like growth factor axis is primarily disrupted, and management of growth ...
Dagdelen Selcuk +3 more
doaj +4 more sources
Protective Activities of Growth Hormone-Releasing Hormone Antagonists against Toxin-Induced Endothelial Injury [PDF]
EndocrinesGHRH regulates the secretion of GH from the anterior pituitary gland, previously associated with cancer progression and inflammation. An emerging body of evidence suggests that GHRHAnt support endothelial barrier function, but the mechanisms mediating ...
Saikat Fakir, Nektarios Barabutis
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Effects of human growth hormone on gonadotropin-releasing hormone neurons in mice [PDF]
Korean Journal of Pediatrics, 2010 PurposeRecombinant human growth hormone (rhGH) has been widely used to treat short stature. However, there are some concerns that growth hormone treatment may induce skeletal maturation and early onset of puberty.
Janardhan P. Bhattarai +3 more
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Growth hormone-releasing hormone-secreting pulmonary neuroendocrine tumor associated with pituitary hyperplasia and somatotropinoma [PDF]
Archives of Endocrinology and Metabolism, 2021 SUMMARY Acromegaly caused by ectopic growth hormone-releasing hormone (GHRH)-secreting tumor is exceedingly rare. We report a case of acromegaly secondary to GHRH secretion by an incidentally diagnosed pulmonary neuroendocrine tumor (NET) and review 47 ...
Elisa B. Lamback +7 more
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