Results 31 to 40 of about 507,904 (333)

Effect of tesamorelin in people with HIV with and without dorsocervical fat: Post hoc analysis of phase III double-blind placebo-controlled trial

Journal of Clinical and Translational Science, 2023
Tesamorelin, a synthetic growth hormone-releasing hormone, is indicated for the reduction of visceral adipose tissue (VAT) in people with HIV. Here, we performed a post hoc analysis of participants receiving tesamorelin for 26 weeks in a phase III ...
Farah Rahman, Taryn McLaughlin, Pedro Mesquita, Josee Morin, Diane Potvin, Marilyn De Chantal, Judith A. Aberg   +6 more
doaj   +1 more source

Actions and Potential Therapeutic Applications of Growth Hormone-Releasing Hormone Agonists.

Endocrinology, 2019
In this article, we briefly review the identification of GHRH, provide an abridged overview of GHRH antagonists, and focus on studies with GHRH agonists. Potent GHRH agonists of JI and MR class were synthesized and evaluated biologically.
A. Schally, Xianyang Zhang, R. Cai, J. Hare, R. Granata, M. Bartoli   +5 more
semanticscholar   +1 more source

Effects of human growth hormone on gonadotropin-releasing hormone neurons in mice [PDF]

Korean Journal of Pediatrics, 2010
PurposeRecombinant human growth hormone (rhGH) has been widely used to treat short stature. However, there are some concerns that growth hormone treatment may induce skeletal maturation and early onset of puberty.
Janardhan P. Bhattarai, Shin Hye Kim, Seong Kyu Han, Mi Jung Park   +3 more
doaj   +1 more source

Growth hormone-releasing hormone attenuates cardiac hypertrophy and improves heart function in pressure overload-induced heart failure

Proceedings of the National Academy of Sciences of the United States of America, 2017
Significance Pathological cardiac hypertrophy, characterized by heart growth in response to pressure or volume overload, such as in the setting of hypertension, is the main risk factor for heart failure (HF).
Iacopo Gesmundo, M. Miragoli, P. Carullo, L. Trovato, V. Larcher, E. Di Pasquale, M. Brancaccio, M. Mazzola, Tania Villanova, Matteo Sorge, M. Taliano, M. P. Gallo, G. Alloatti, C. Penna, J. Hare, E. Ghigo, A. Schally, G. Condorelli, R. Granata   +18 more
semanticscholar   +1 more source

The decrease in growth hormone (GH) response after repeated stimulation with GH-Releasing hormone is partly caused by an elevation of somatostatin tonus. [PDF]

, 1996
Repeated injection of GHRH leads to a decrease in the GH response in normal subjects. Arginine (Arg) stimulates GH secretion by suppression of hypothalamic somatostatin.
Mehltretter, Gerhard, Mojto, Juraj, Müller, Otto-Albrecht, Reichardt, Bärbel, Schopohl, Jochen, Schrader, Monika   +5 more
core   +1 more source

Agonists of growth hormone-releasing hormone (GHRH) inhibit human experimental cancers in vivo by down-regulating receptors for GHRH

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance This study demonstrates that the growth hormone-releasing hormone (GHRH) agonist MR409 exerts agonistic action in cancer cells in vitro but, in vivo, suppresses tumor growth of human experimental lung cancers and other cancers.
A. Schally, Haibo Wang, Jinlin He, R. Cai, W. Sha, Petra Popovics, R. Perez, Irving Vidaurre, Xianyang Zhang   +8 more
semanticscholar   +1 more source

Human Pancreas GH-Releasing Factor Analog Restores High-Amplitude GH Pulses in CNS Lesion-Induced GH Deficiency [PDF]

, 1983
Lesions of the ventromedial-arcuate (VMH-ARC) region of the hypothalamus result in impaired growth accompanied by a marked suppression in spontaneous GH secretory bursts. We studied the effects of an analog of the recently characterized human pancreas GH-
Eikelboom, Rudy, Ling, Nicholas, Schaffer Tannenbaum, Gloria   +2 more
core   +2 more sources

Protective effects of agonists of growth hormone-releasing hormone (GHRH) in early experimental diabetic retinopathy

Proceedings of the National Academy of Sciences of the United States of America, 2017
Significance The studies described here are relevant to the cure of diabetic retinopathy, a leading cause of blindness with currently limited therapeutic options.
Menaka C Thounaojam, F. L. Powell, Sagar Y. Patel, D. Gutsaeva, A. Tawfik, Sylvia B. Smith, Julian J. Nussbaum, N. Block, Pamela M. Martin, A. Schally, M. Bartoli   +10 more
semanticscholar   +1 more source

Corticotropin-releasing hormone as the homeostatic rheostat of feto-maternal symbiosis and developmental programming In utero and neonatal life [PDF]

, 2017
A balanced interaction between the homeostatic mechanisms of mother and the devel- oping organism during pregnancy and in early neonatal life is essential in order to ensure optimal fetal development, ability to respond to various external and internal ...
Alcantara-Alonso, Alexander, Arborelius, Bale, Baram, Barker, Bellisario, Benjamin Neelon, Bosch, Bouret, Bowman, Briana, Brummelte, Brunson, Brunton, Brunton, Brunton, Brunton, Capron, Chen, Chen, Choy, Cirulli, Cirulli, Class, Clifton, Cottrell, Dallman, Davis, de Weerth, Demendi, Desai, Dimasuay, Dunkel, D’Amato, Eghbal-Ahmadi, Ehlers, Ellman, Entringer, Fasting, Faturi, Fenoglio, Gao, Gillman, Glynn, Gomez-Roig, Grammatopoulos, Gunnar, Harville, Hollrigel, Husum, Ibanez, Kammerer, Kensara, Korosi, Labonte, Ladyman, Larsen, Lee, Lockwood, Machado, MacKay, Maffeis, Magiakou, Maniam, Marciniak, McLean, Mingrone, Owens, Pasquali, Paternain, Pedersen, Pelleymounter, Peng, Perrone, Pervanidou, Petraglia, Pihoker, Plotsky, Purcell, Robinson, Romens, Sanchez, Sandman, Sandman, Schmidt, Schulte, Seckl, Seckl, Sferruzzi-Perri, Shapiro, Singh-Taylor, Smith, Soma-Pillay, Stout, Suderman, Sun, Symonds, Tamashiro, Turecki, van Bodegom, Vazquez, Vickers, Wadhwa, Wakahashi, Walker, Wang, Weaver, Weaver, Weinstock, Whitaker, Whitehead, Wolfe, Yam, Zambrano   +114 more
core   +3 more sources

Growth-hormone-releasing hormone

Clinical Chemistry, 1990
Abstract Growth-hormone-releasing hormone (GHRH, somatoliberin) is the hypothalamic peptide hormone that specifically stimulates synthesis and release of growth hormone (GH, somatotropin) by somatotrope cells of the anterior pituitary gland.
openaire   +2 more sources