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Benign prostatic hyperplasia often affects aging men. Antagonists of the neuropeptide growth hormone-releasing hormone reduced prostate weight in an androgen induced benign prostatic hyperplasia model in rats.
Ferenc Rick, Mehrdad Nadji
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The Journal of Clinical Endocrinology & Metabolism, 1990
Recent studies in the rat have shown that intracerebroventricular administration of CRH inhibited spontaneous pulsatile GH secretion and prevented GH-releasing hormone (GHRH)-induced GH release. We have studied the effect of CRH on GHRH-induced GH release in man.
Barbarino, Antonino +7 more
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Recent studies in the rat have shown that intracerebroventricular administration of CRH inhibited spontaneous pulsatile GH secretion and prevented GH-releasing hormone (GHRH)-induced GH release. We have studied the effect of CRH on GHRH-induced GH release in man.
Barbarino, Antonino +7 more
openaire +3 more sources
Inhibition of growth hormone and thyrotropin release by growth hormone-release inhibiting hormone
Molecular and Cellular Endocrinology, 1974Abstract Addition of increasing doses of synthetic growth hormone-release inhibiting hormone (GH-RIH) leads to a progressive decrease of the basal and N 6 monobutyryl cyclic AMP-,theophylline- and prostaglandin E 2 -induced release of immunoreactive growth hormone (GH) and thyrotropin (TSH) release from rat anterior pituitary cells in monolayer ...
A, Belanger +12 more
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Analogs of Growth Hormone-Releasing Hormone Induce Release of Growth Hormone in the Bovine
Journal of Animal Science, 1988Biological potencies of three 29 amino acid growth hormone-releasing hormone analogs (GHRH[1-29]) were determined in the bovine and compared to synthetic human GHRH (44 amino acids; hGHRH[1-44]NH2) for their ability to increase serum growth hormone (GH) concentrations. Four prepubertal Holstein heifers (179 +/- 10 kg) received hGHRH(1-44)NH2 or analogs
R, Scarborough +3 more
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The growth hormone-releasing hormone receptor
2001Publisher Summary This chapter describes growth hormone (GH) as a polypeptide secreted by the somatotroph cells of the anterior pituitary gland, is the primary stimulator of linear growth in vertebrates and is involved in the regulation of protein and fat metabolism.
V I, DeAlmeida, K E, Mayo
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Growth Hormone Releasing Hormone and Growth Hormone Releasing Peptides
1995The regulation of growth hormone (GH) secretion in humans is a complex entity involving primary regulators and secondary modifiers that influence both the amount and pattern of GH release. The primary regulators are the hypothalamic hormones: somatostatin (SRIH) and growth hormone releasing hormone (GHRH).
Mary Lee Vance +4 more
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Growth Hormone Releasing Hormone Receptor
Receptors and Channels, 2002Growth hormone releasing hormone receptor (GHRH-R) is a class II G protein-coupled receptor required for normal growth hormone (GH) synthesis and release from the pituitary, and for the normal growth and proliferation of somatotrophs within the pituitary.
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Growth hormone-releasing hormone and cancer
Reviews in Endocrine and Metabolic DisordersThe hypothalamic hormone growth hormone-releasing hormone (GHRH), in addition to promoting the synthesis and release of growth hormone (GH), stimulates the proliferation of human normal and malignant cells by binding to GHRH-receptor (GHRH-R) and its main splice variant, SV1. Both GHRH and GHRH-Rs are expressed in various cancers, forming a stimulatory
Iacopo, Gesmundo +5 more
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Growth hormone- and growth-hormone-releasing hormone-producing tumors
1997Acromegaly, a clinical syndrome of disordered somatic growth and proportion, is usually caused by the unrestrained secretion of growth hormone (GH) by a pituitary adenoma and rarely may result from GH-releasing hormone (GHRH) secretion by an extrapituitary tumor.
I, Shimon, S, Melmed
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Growth Hormone-Releasing Hormone
Biology of the Neonate, 2009Plasma growth hormone-releasing hormone (GHRH) was measured by radioimmunoassay in the cord blood from 32 healthy human newborns after 38–41 weeks of gestation. All were born by uncomplicated vaginal delivery. The GHRH levels in cord blood were 78.33 ± 8.35 pg/ml at 40 weeks of gestation, approximately threefold higher than the levels at 38 weeks of ...
Jesus Argente +4 more
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