Visualization of the existence of growth hormone secretagogue receptor in the rat nucleus accumbens [PDF]
Molecular BrainThe potential role of the ghrelin receptor, also known as the growth hormone secretagogue receptor (GHSR), within the nucleus accumbens (NAcc) in regulating drug addiction and feeding has been documented; however, the pattern of its expression in this ...
Seohyeon Lee +3 more
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Expression of the growth hormone secretagogue receptor 1a (GHS‐R1a) in the brain [PDF]
Physiological Reports, 2021 The review presents data on the expression of growth hormone secretagogue receptor 1a (GHS‐R1a) in the brain regions in model animals (zebrafish, rodents, primates), and in the human brain.
Marat I. Airapetov +4 more
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Adenosine Is an Agonist of the Growth Hormone Secretagogue Receptor [PDF]
Endocrinology, 2000 Growth hormone secretagogues (GHSs) are synthetic compounds that induce GH release in several species, including man. The aim of the current study was to identify hypothalamic GHS receptor (GHS-R) agonists. This led to the discovery of adenosine as a GHS-R agonist.
Søren Tullin +5 more
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Binding Domain Characterization of Growth Hormone Secretagogue Receptor. [PDF]
J Transl Int Med, 2022 Abstract Background and Objectives Activation of ghrelin receptor growth hormone secretagogue receptor (GHS-R) by endogenous or synthetic ligands amplifies pulsatile release of growth hormone (GH) and enhances food intake, very relevant to development and growth.
Sun Y +4 more
europepmc +3 more sources
The ups and downs of growth hormone secretagogue receptor signaling [PDF]
The FEBS Journal, 2021 The growth hormone secretagogue receptor (GHSR) has emerged as one of the most fascinating molecules from the perspective of neuroendocrine control. GHSR is mainly expressed in the pituitary and the brain, and plays key roles regulating not only growth hormone secretion but also food intake, adiposity, body weight, glucose homeostasis and other complex
María Paula Cornejo +5 more
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LEAP2 Impairs the Capability of the Growth Hormone Secretagogue Receptor to Regulate the Dopamine 2 Receptor Signaling [PDF]
Frontiers in Pharmacology, 2021 The growth hormone secretagogue receptor (GHSR) signals in response to ghrelin, but also acts via ligand-independent mechanisms that include either constitutive activation or interaction with other G protein-coupled receptors, such as the dopamine 2 ...
Emilio R. Mustafá +11 more
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Growth Hormone Secretagogue Receptor 1A Antagonist JMV2959 Effectively Prevents Morphine Memory Reconsolidation and Relapse [PDF]
Frontiers in Pharmacology, 2021 Relapse to drug seeking after prolonged abstinence is a major problem in the clinical treatment of drug addiction. The use of pharmacological interventions to disrupt established drug reward memories is a promising strategy for the treatment of drug ...
Jing Zhao +3 more
doaj +2 more sources
Novel mechanisms of growth hormone regulation: growth hormone-releasing peptides and ghrelin [PDF]
Brazilian Journal of Medical and Biological Research, 2006 Growth hormone secretion is classically modulated by two hypothalamic hormones, growth hormone-releasing hormone and somatostatin. A third pathway was proposed in the last decade, which involves the growth hormone secretagogues.
A.-M.J. Lengyel
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Deletion of Growth Hormone Secretagogue Receptor in Kisspeptin Neurons in Female Mice Blocks Diet-Induced Obesity [PDF]
Biomolecules, 2022 The gut peptide, ghrelin, mediates energy homeostasis and reproduction by acting through its receptor, growth hormone secretagogue receptor (GHSR), expressed in hypothalamic neurons in the arcuate (ARC).
Kristie Conde +9 more
doaj +2 more sources
Molecular Metabolism, 2015 Background: The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the ...
T.D. Müller +56 more
doaj +7 more sources