Expression of the growth hormone secretagogue receptor 1a (GHS‐R1a) in the brain [PDF]
Physiological Reports, 2021 The review presents data on the expression of growth hormone secretagogue receptor 1a (GHS‐R1a) in the brain regions in model animals (zebrafish, rodents, primates), and in the human brain.
Marat I. Airapetov +4 more
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LEAP2 Impairs the Capability of the Growth Hormone Secretagogue Receptor to Regulate the Dopamine 2 Receptor Signaling [PDF]
Frontiers in Pharmacology, 2021 The growth hormone secretagogue receptor (GHSR) signals in response to ghrelin, but also acts via ligand-independent mechanisms that include either constitutive activation or interaction with other G protein-coupled receptors, such as the dopamine 2 ...
Emilio R. Mustafá +11 more
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The growth hormone secretagogue receptor: its intracellular signaling and regulation. [PDF]
Int J Mol Sci, 2014 The growth hormone secretagogue receptor (GHSR), also known as the ghrelin receptor, is involved in mediating a wide variety of biological effects of ghrelin, including: stimulation of growth hormone release, increase of food intake and body weight, modulation of glucose and lipid metabolism, regulation of gastrointestinal motility and secretion ...
Yin Y, Li Y, Zhang W.
europepmc +6 more sources
Growth Hormone Secretagogue Receptor Dimers: A New Pharmacological Target [PDF]
eNeuro, 2015 AbstractThe growth hormone secretagogue receptor (GHSR1a), the target of the ghrelin peptide, is widely distributed throughout the brain, and, while studies have often reported very low or absent levels of central ghrelin, it is now known that GHSR1a, even in the absence of a natural ligand, has physiological roles.
Wellman M, Abizaid A.
europepmc +5 more sources
Binding Domain Characterization of Growth Hormone Secretagogue Receptor. [PDF]
J Transl Int Med, 2022 Abstract Background and Objectives Activation of ghrelin receptor growth hormone secretagogue receptor (GHS-R) by endogenous or synthetic ligands amplifies pulsatile release of growth hormone (GH) and enhances food intake, very relevant to development and growth.
Sun Y +4 more
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Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity [PDF]
Journal of Clinical Investigation, 2002 Growth hormone secretagogues (GHSs) stimulate GH secretion and food intake. GHS receptor (GHS-R) mRNA has been identified mainly in the arcuate nucleus (Arc) and ventromedial nucleus of the hypothalamus and in the pituitary. Ghrelin, an endogenous ligand for GHS-R, has recently been purified from rat stomach.
Yujin Shuto +9 more
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Growth Hormone Secretagogue Receptor 1A Antagonist JMV2959 Effectively Prevents Morphine Memory Reconsolidation and Relapse [PDF]
Frontiers in Pharmacology, 2021 Relapse to drug seeking after prolonged abstinence is a major problem in the clinical treatment of drug addiction. The use of pharmacological interventions to disrupt established drug reward memories is a promising strategy for the treatment of drug ...
Jing Zhao +3 more
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Regional Differences in the Ghrelin-Growth Hormone Secretagogue Receptor Signalling System in Human Heart Disease [PDF]
CJC Open, 2021 Background: The hormone ghrelin and its receptor, the growth hormone secretagogue receptor (GHSR) are expressed in myocardium. GHSR binding activates signalling pathways coupled to cardiomyocyte survival and contractility.
Rebecca Sullivan, BSc +7 more
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Deletion of Growth Hormone Secretagogue Receptor in Kisspeptin Neurons in Female Mice Blocks Diet-Induced Obesity [PDF]
Biomolecules, 2022 The gut peptide, ghrelin, mediates energy homeostasis and reproduction by acting through its receptor, growth hormone secretagogue receptor (GHSR), expressed in hypothalamic neurons in the arcuate (ARC).
Kristie Conde +9 more
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Nutrient-sensing growth hormone secretagogue receptor in macrophage programming and meta-inflammation [PDF]
Molecular MetabolismObjective: Obesity-associated chronic inflammation, aka meta-inflammation, is a key pathogenic driver for obesity-associated comorbidity. Growth hormone secretagogue receptor (GHSR) is known to mediate the effects of nutrient-sensing hormone ghrelin in ...
Da Mi Kim +13 more
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