The ups and downs of growth hormone secretagogue receptor signaling [PDF]
The FEBS Journal, 2021 The growth hormone secretagogue receptor (GHSR) has emerged as one of the most fascinating molecules from the perspective of neuroendocrine control. GHSR is mainly expressed in the pituitary and the brain, and plays key roles regulating not only growth hormone secretion but also food intake, adiposity, body weight, glucose homeostasis and other complex
María Paula Cornejo +5 more
semanticscholar +6 more sources
Ghrelin transport across the blood–brain barrier can occur independently of the growth hormone secretagogue receptor [PDF]
Molecular Metabolism, 2018 Objective: The blood–brain barrier (BBB) regulates the entry of substrates and peptides into the brain. Ghrelin is mainly produced in the stomach but exerts its actions in the central nervous system (CNS) by crossing the BBB.
Elizabeth M. Rhea +5 more
doaj +3 more sources
Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor [PDF]
Proceedings of the National Academy of Sciences, 2004 Synthetic agonists of the growth hormone secretagogue receptor (GHSR) rejuvenate the pulsatile pattern of GH-release in the elderly, and increase lean but not fat mass in obese subjects. Screening of tissue extracts in a cell line engineered to overexpress the GHSR led to the identification of a natural agonist called ghrelin.
Yuxiang Sun +3 more
semanticscholar +6 more sources
The growth hormone secretagogue receptor: its intracellular signaling and regulation. [PDF]
Int J Mol Sci, 2014 The growth hormone secretagogue receptor (GHSR), also known as the ghrelin receptor, is involved in mediating a wide variety of biological effects of ghrelin, including: stimulation of growth hormone release, increase of food intake and body weight, modulation of glucose and lipid metabolism, regulation of gastrointestinal motility and secretion ...
Yin Y, Li Y, Zhang W.
europepmc +6 more sources
The Ghrelin/Growth Hormone Secretagogue Receptor System Is Involved in the Rapid and Sustained Antidepressant-Like Effect of Paeoniflorin [PDF]
Frontiers in Neuroscience, 2021 Major depressive disorder (MDD) is a debilitating mental illness affecting people worldwide. Although significant progress has been made in the development of therapeutic agents to treat this condition, fewer than half of all patients respond to ...
Yuan Zhang +13 more
doaj +2 more sources
Growth hormone secretagogue receptor is important in the development of experimental colitis. [PDF]
Cell Biosci, 2015 Growth hormone secretagogue receptor (GHSR) and its ligand, ghrelin, are important modulators in weight control and energy homeostasis. Recently, ghrelin is also involved in experimental colitis, but the role of GHSR in the development of colitis is unclear.
Liu ZZ +9 more
europepmc +6 more sources
Growth Hormone Secretagogue Receptor Dimers: A New Pharmacological Target [PDF]
eNeuro, 2015 AbstractThe growth hormone secretagogue receptor (GHSR1a), the target of the ghrelin peptide, is widely distributed throughout the brain, and, while studies have often reported very low or absent levels of central ghrelin, it is now known that GHSR1a, even in the absence of a natural ligand, has physiological roles.
Wellman M, Abizaid A.
europepmc +6 more sources
Diversification and coevolution of the ghrelin/growth hormone secretagogue receptor system in vertebrates. [PDF]
Ecol Evol, 2016 AbstractThe gut hormone ghrelin is involved in numerous metabolic functions, such as the stimulation of growth hormone secretion, gastric motility, and food intake. Ghrelin is modified by ghrelin O‐acyltransferase (GOAT) or membrane‐bound O‐acyltransferase domain‐containing 4 (MBOAT4) enabling action through the growth hormone secretagogue receptors ...
Tine M +4 more
europepmc +7 more sources
How the ghrelin receptor recognizes the acyl-modified orexigenic hormone [PDF]
Frontiers in Molecular NeuroscienceGhrelin, discovered in 1999 as an endogenous ligand of the growth hormone secretagogue receptor (now known as the ghrelin receptor), is a peptide hormone with diverse physiological activities, such as stimulation of growth hormone release, increased ...
Yuki Shiimura +3 more
doaj +2 more sources
Adenosine Is an Agonist of the Growth Hormone Secretagogue Receptor [PDF]
Endocrinology, 2000 Growth hormone secretagogues (GHSs) are synthetic compounds that induce GH release in several species, including man. The aim of the current study was to identify hypothalamic GHS receptor (GHS-R) agonists. This led to the discovery of adenosine as a GHS-R agonist.
Søren Tullin +5 more
+5 more sources