The Ghrelin/Growth Hormone Secretagogue Receptor System Is Involved in the Rapid and Sustained Antidepressant-Like Effect of Paeoniflorin [PDF]
Frontiers in Neuroscience, 2021 Major depressive disorder (MDD) is a debilitating mental illness affecting people worldwide. Although significant progress has been made in the development of therapeutic agents to treat this condition, fewer than half of all patients respond to ...
Yuan Zhang +13 more
doaj +2 more sources
Ghrelin transport across the blood–brain barrier can occur independently of the growth hormone secretagogue receptor [PDF]
Molecular Metabolism, 2018 Objective: The blood–brain barrier (BBB) regulates the entry of substrates and peptides into the brain. Ghrelin is mainly produced in the stomach but exerts its actions in the central nervous system (CNS) by crossing the BBB.
Elizabeth M. Rhea +5 more
doaj +2 more sources
Signal transduction mechanism of the seabream growth hormone secretagogue receptor
FEBS Letters, 2004 We have recently cloned the full‐length cDNAs of the two growth hormone secretagogue receptor (GHSR) subtypes from a teleost species, the black seabream ( Acanthopagrus schlegeli ) [Mol. Cell. Endocrinol. 214 (2004) 81], namely sbGHSR‐1a and sbGHSR‐1b.
Cheng, Christopher H K +3 more
openaire +5 more sources
Development and Characterization of an F-labeled Ghrelin Peptidomimetic for Imaging the Cardiac Growth Hormone Secretagogue Receptor [PDF]
Molecular Imaging, 2018 One-third of patients with heart disease develop heart failure, which is diagnosed through imaging and detection of circulating biomarkers. Imaging strategies reveal morphologic and functional changes but fall short of detecting molecular abnormalities ...
Ahmed Abbas MSc +6 more
doaj +2 more sources
Binding Domain Characterization of Growth Hormone Secretagogue Receptor. [PDF]
J Transl Int Med, 2022 Abstract Background and Objectives Activation of ghrelin receptor growth hormone secretagogue receptor (GHS-R) by endogenous or synthetic ligands amplifies pulsatile release of growth hormone (GH) and enhances food intake, very relevant to development and growth.
Sun Y +4 more
europepmc +3 more sources
Characterization of a Monoclonal Antibody Specific for the Growth Hormone Secretagogue Receptor
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 2017 Ghrelin is an orexigenic peptide hormone that primarily regulates growth hormone secretion, food intake, and energy homeostasis. It has been shown to also play a role in numerous higher brain functions, such as the regulation of inflammation and cell proliferation. Ghrelin is the endogenous ligand of the growth hormone secretagogue receptor (GHSR), a G-
Katia, Crotta +5 more
openaire +3 more sources
The Growth Hormone Secretagogue Receptor (Ghs-R)
Current Pharmaceutical Design, 2012 The growth hormone secretagogue receptor (GHS-R) is a component of the ghrelin signaling pathway and is involved in mediating the pleiotropic effects of ghrelin. Two isoforms have been identified, but only GHS-R1a binds with acyl ghrelin and transduces its message.
LAVIANO, Alessandro +3 more
openaire +4 more sources
The expression and function of growth hormone secretagogue receptor in immune cells: A current perspective. [PDF]
Exp Biol Med (Maywood), 2022 Noh JY +5 more
europepmc +2 more sources
Distribution and regulation of chicken growth hormone secretagogue receptor isoforms
General and Comparative Endocrinology, 2003 Chicken ghrelin has recently been isolated as a hormone which stimulates growth hormone and corticosterone secretion in chicken. Ghrelin mediates these actions in mammals by binding to the growth hormone secretagogue receptor (GHS-R). In this study, we describe the partial cloning of two chicken GHS-R (cGHS-R) isoforms: cGHS-R1a and cGHS-R1c.
S M E, Geelissen +4 more
openaire +3 more sources
Gene amplifications associated with the development of hormone- resistant prostate cancer [PDF]
, 2003 Purpose: Hormone resistance remains a significant clinical problem in prostate cancer with few therapeutic options. Research into mechanisms of hormone resistance is essential.
Krishnan, S. +3 more
core +8 more sources